Branched-Chain Amino Acids and Inflammation Management in Endurance Sports: Molecular Mechanisms and Practical Implications DOI Open Access

Miaomiao Xu,

Danhong Hu,

Xiaoguang Liu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1335 - 1335

Published: April 12, 2025

Endurance athletes frequently experience muscle damage and inflammation due to prolonged, high-intensity exercise, which can impair recovery hinder performance. This review examines the role of branched-chain amino acid (BCAA) supplementation in repair, modulation, immune regulation. BCAAs—particularly leucine isoleucine—activate key molecular pathways, including mechanistic target rapamycin (mTOR) AMP-activated protein kinase (AMPK), promote synthesis enhance energy metabolism. They also attenuate inflammatory responses by modulating nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), mitogen-activated (MAPK), Janus kinase/signal transducer activator transcription (JAK/STAT) reducing levels tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6). In addition, BCAAs influence function via complex 1 (mTORC1) signaling, autophagy, mitigate exercise-induced apoptosis. These effects result reduced soreness, lower biomarker (e.g., creatine kinase, lactate dehydrogenase), improved recovery. Practical considerations such as optimal dosage, timing, co-supplementation with carbohydrates, proteins, or omega-3s are addressed. While show promise a nutritional strategy for enhancing controlling endurance athletes, further research is needed refine personalized protocols clarify long-term effects.

Language: Английский

Branched-Chain Amino Acids and Inflammation Management in Endurance Sports: Molecular Mechanisms and Practical Implications DOI Open Access

Miaomiao Xu,

Danhong Hu,

Xiaoguang Liu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1335 - 1335

Published: April 12, 2025

Endurance athletes frequently experience muscle damage and inflammation due to prolonged, high-intensity exercise, which can impair recovery hinder performance. This review examines the role of branched-chain amino acid (BCAA) supplementation in repair, modulation, immune regulation. BCAAs—particularly leucine isoleucine—activate key molecular pathways, including mechanistic target rapamycin (mTOR) AMP-activated protein kinase (AMPK), promote synthesis enhance energy metabolism. They also attenuate inflammatory responses by modulating nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), mitogen-activated (MAPK), Janus kinase/signal transducer activator transcription (JAK/STAT) reducing levels tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6). In addition, BCAAs influence function via complex 1 (mTORC1) signaling, autophagy, mitigate exercise-induced apoptosis. These effects result reduced soreness, lower biomarker (e.g., creatine kinase, lactate dehydrogenase), improved recovery. Practical considerations such as optimal dosage, timing, co-supplementation with carbohydrates, proteins, or omega-3s are addressed. While show promise a nutritional strategy for enhancing controlling endurance athletes, further research is needed refine personalized protocols clarify long-term effects.

Language: Английский

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