Systematic Review of Relevant Biomarkers for Human Connective Tissue Repair and Healing Outcome: Implications for Understanding Healing Processes and Design of Healing Interventions DOI
Junyu Chen, Xiaoxue Fu, Aisha Ahmed

et al.

Advances in Wound Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Objective: The healing process following connective tissue (CT) injuries is complex, resulting in variable and often suboptimal outcomes. Patients undergoing CT repair frequently experience failures, compromised function, chronic degenerative diseases. identification of biomarkers to guide improved clinical outcomes after remains an emerging but promising field. [Figure: see text] Design: Systematic review. Data sources: Databases, including PubMed, MEDLINE Ovid, Web Science, Google Scholar, were searched up August 2024. Eligibility criteria: To achieve the research objective, randomized control trials, cohort studies, case-control studies on associated with selected. present analysis was confined preclinical models, excluding imaging studies. entire this systematic review adhered strictly guidelines outlined Preferred Reporting Items for Review Meta-Analyses protocol checklist. Results: A total 1,815 initially identified, 75 meeting eligibility criteria 55 passing quality assessments. For outcomes, 281 considered, 30 24 Twenty-one overlapping investigated effects both Specific ranked from highest lowest quality, include complement factor D, eukaryotic elongation factor-2, procollagen type I N-terminal propetide, III lactate, pyruvate, platelet-derived growth factor-BB, inhibitor metalloproteinase-3 (TIMP-3), cysteine-rich protein-1, plastin-3, periostin, protein S100-A11, vimentin, matrix metalloproteinases (MMP-2, MMP-7, MMP-9), hepatocyte factor, interferon-γ, interleukins (IL-6, IL-8, IL-10), MMP-1, MMP-3, tumor necrosis factor-α, fibroblast IL-1α, chondroitin-6-sulfate, inter-alpha-trypsin heavy chain-4, transforming factor-beta 1, vascular endothelial C-C chemokine receptor 7, ligand 19, IL-1β, IL-1Ra, IL-12p40, granulocyte-macrophage colony-stimulating (GM-CSF), TIMP-1. Conclusions: All 37 identified potential demonstrated regulatory mediated Notably, human can potentially play essential role development targeted treatment protocols counteract also serve as predictors detecting processes long-term

Language: Английский

Systematic Review of Relevant Biomarkers for Human Connective Tissue Repair and Healing Outcome: Implications for Understanding Healing Processes and Design of Healing Interventions DOI
Junyu Chen, Xiaoxue Fu, Aisha Ahmed

et al.

Advances in Wound Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Objective: The healing process following connective tissue (CT) injuries is complex, resulting in variable and often suboptimal outcomes. Patients undergoing CT repair frequently experience failures, compromised function, chronic degenerative diseases. identification of biomarkers to guide improved clinical outcomes after remains an emerging but promising field. [Figure: see text] Design: Systematic review. Data sources: Databases, including PubMed, MEDLINE Ovid, Web Science, Google Scholar, were searched up August 2024. Eligibility criteria: To achieve the research objective, randomized control trials, cohort studies, case-control studies on associated with selected. present analysis was confined preclinical models, excluding imaging studies. entire this systematic review adhered strictly guidelines outlined Preferred Reporting Items for Review Meta-Analyses protocol checklist. Results: A total 1,815 initially identified, 75 meeting eligibility criteria 55 passing quality assessments. For outcomes, 281 considered, 30 24 Twenty-one overlapping investigated effects both Specific ranked from highest lowest quality, include complement factor D, eukaryotic elongation factor-2, procollagen type I N-terminal propetide, III lactate, pyruvate, platelet-derived growth factor-BB, inhibitor metalloproteinase-3 (TIMP-3), cysteine-rich protein-1, plastin-3, periostin, protein S100-A11, vimentin, matrix metalloproteinases (MMP-2, MMP-7, MMP-9), hepatocyte factor, interferon-γ, interleukins (IL-6, IL-8, IL-10), MMP-1, MMP-3, tumor necrosis factor-α, fibroblast IL-1α, chondroitin-6-sulfate, inter-alpha-trypsin heavy chain-4, transforming factor-beta 1, vascular endothelial C-C chemokine receptor 7, ligand 19, IL-1β, IL-1Ra, IL-12p40, granulocyte-macrophage colony-stimulating (GM-CSF), TIMP-1. Conclusions: All 37 identified potential demonstrated regulatory mediated Notably, human can potentially play essential role development targeted treatment protocols counteract also serve as predictors detecting processes long-term

Language: Английский

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