Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort DOI Open Access

Ayushi Trivedi,

Dipro Bose,

Kelly Moffat

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1102 - 1102

Published: Aug. 21, 2024

Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990–1991 War. Fatigue, GI complaints, other symptoms continue persist more than 30 years post-deployment. Several potential mechanisms for persistent illness have been identified our prior pilot study linked an altered gut microbiome with disorder. This further validates builds on preliminary findings of host dysbiosis GWI. Using stool samples Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases 26 controls) Boston biorepository, recruitment, integrative network (BBRAIN) Illness, we found that bacterial signature showed significantly different Bray–Curtis beta diversity control veterans. Specifically, higher Firmicutes Bacteroidetes ratio, decrease Akkermansia sp., Bacteroides thetaiotamicron, fragilis, Lachnospiraceae genera increase Blautia, Streptococcus, Klebsiella, Clostridium genera, are associated gut, immune, brain health, shown. Further, using MaAsLin Boruta algorithms, Coprococcus Eisenbergiella as important predictors area under curve ROC predictive value 74.8%. Higher self-reported MFI scores also species abundance Blautia. These results suggest therapeutic targets target specific illness.

Language: Английский

Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort DOI Open Access

Ayushi Trivedi,

Dipro Bose,

Kelly Moffat

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1102 - 1102

Published: Aug. 21, 2024

Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990–1991 War. Fatigue, GI complaints, other symptoms continue persist more than 30 years post-deployment. Several potential mechanisms for persistent illness have been identified our prior pilot study linked an altered gut microbiome with disorder. This further validates builds on preliminary findings of host dysbiosis GWI. Using stool samples Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases 26 controls) Boston biorepository, recruitment, integrative network (BBRAIN) Illness, we found that bacterial signature showed significantly different Bray–Curtis beta diversity control veterans. Specifically, higher Firmicutes Bacteroidetes ratio, decrease Akkermansia sp., Bacteroides thetaiotamicron, fragilis, Lachnospiraceae genera increase Blautia, Streptococcus, Klebsiella, Clostridium genera, are associated gut, immune, brain health, shown. Further, using MaAsLin Boruta algorithms, Coprococcus Eisenbergiella as important predictors area under curve ROC predictive value 74.8%. Higher self-reported MFI scores also species abundance Blautia. These results suggest therapeutic targets target specific illness.

Language: Английский

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