Copper Complexes with New Glycyl-l-histidyl-l-lysine–Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects DOI
Valentina Greco, Valeria Lanza, Barbara Tomasello

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

In recent years, hyaluronic acid (HA) and the natural tripeptide glycyl-l-histidyl-l-lysine (GHK), especially its copper(II) complex (GHK-Cu), individually have been shown to exert helpful properties for bone protection regeneration. However, they are not strong enough handle oxidative stress, hydrolytic attack, or environmental conditions. Being aware that conjugation chemistry has recently emerged as an appealing approach generating new molecular entities capable of preserving integrity their moieties delaying degradation, herein we present synthesis conjugates HA with GHK (GHK-HA), at different loadings tripeptide. GHK-HA binds ions potentiates chemical biological two components in vitro assays. The results highlight copper's role promoting expression release certain trophic, angiogenic, osteogenic factors, including brain-derived neurotrophic factor (BDNF), vascular endothelial growth (VEGF), well morphogenetic protein-2 (BMP-2). protective regenerative activities metal ion related translocation intracellular chaperones Copper Chaperone Superoxide Dismutase (CCS) Antioxidant-1 (Atox1) nucleus where act transcription factors.

Language: Английский

A Comparison of the Treatment Effects of a Risperidone Solution, an Equal Ratio of DHA/ARA, and a Larger Ratio of Omega-6 PUFA Added to Omega-3 PUFA: An Open-Label Clinical Trial DOI Creative Commons
Kunio Yui, George Imataka

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 184 - 184

Published: March 12, 2025

We aimed to assess the efficacy, safety, and pharmacokinetics of an oral risperidone solution two types supplementations with PUFAs. assigned 39 participants mild ASD (mean age ± standard deviation = 14.6 6.0 years) three treatment groups (each n 13): RIS-OS; equal doses 240 mg omega-3 PUFA docosahexaenoic acid omega-6 arachidonic (1:1) (aravita); precursor linoleic (480 mg) alpha-linolenic (120 (4:1) (awake). The primary outcome was Autism Diagnostic Interview—Revised score. secondary outcomes were Social Responsiveness Scale (SRS) Aberrant Behavior Check scores. results linear mixed-effects model revealed that RIS-OS group exhibited significant improvement in SRS subscale scores social motivation at weeks 8, 12, 16 compared aravita awake groups, as well score mannerisms 12 group. Moreover, showed a trend towards significantly lower plasma ceruloplasmin (Cp) levels. Their insulin-like growth factor (IGF) levels higher week 8 than subsequent weeks. high Cp IGF may be attributed reduced neuroinflammation. These findings demonstrate, firstly, inflammation through increased anti-inflammatory proteins such has clinical effects on motivation–reward system patients amelioration dopamine D2, 5-HT2a, 5-HT2b dysfunction.

Language: Английский

Citations

0
Bisdemethoxycurcumin chemoprevents 7,12-dimethylbenz(a)anthracene-induced mammary toxicity via modulation of oxidative processes DOI Creative Commons

Adedoyin O. Adefisan-Adeoye,

Oluwaferanmi O. Ayanbanjo,

Temitope D. Adeoye

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Bisdemethoxycurcumin (BDMC) is a naturally occurring compound having anti-cancer properties. We investigated the effect of BDMC on DMBA-induced mammary toxicity in female Wistar rats. Forty-eight virgin rats were divided into six groups at random. Group 1 received corn oil, group 2 DMBA (50 mg/kg), 3 and 4 (25 mg/kg 50 5 6 vincristine. A single dosage was administered (i.p.) weeks, followed by (orally) vincristine three times week for thirteen weeks. The significantly increased lactate dehydrogenase activity 1.3 folds. Similarly, nitric oxide, malondialdehyde, myeloperoxidase activities 12, 204, 6.3%, respectively. DMBA-rats decreases glutathione-S-transferase, superoxide dismutase, glutathione peroxidase activities. Immunohistochemistry analysis revealed that B-cell lymphoma-2, estrogen receptor, human epidermal receptor-2 strongly expressed DMBA-rats, but progesterone receptor Bcl-2 associated protein weakly expressed. In rats, histology glands with moderate proliferating ducts fibrosis. Co-treatment reduces hormone receptors activities, improved antioxidant apoptotic status. protected gland from targeting cellular pathways involved oxidative stress apoptosis.

Language: Английский

Citations

0
Transfer of Antioxidant Capacity Through Placenta and Colostrum: β-Carotene and Superoxide Dismutase Collaboratively Enhance Integrated Breeding of Sows and Piglets DOI Creative Commons
Jun Huang, Shengkai Li, Jung Yeol Sung

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 359 - 359

Published: March 18, 2025

Sows and piglets face heightened oxidative stress during gestation lactation, yet strategies to simultaneously mitigate these challenges remain underexplored. This study investigated the effects of β-carotene superoxide dismutase (SOD) supplementation on 140 Landrace × Yorkshire sows (parity 3-5) randomly assigned (1) a control; (2) long-term low-dose treatment (25 mg/kg β-carotene, 4 SOD, or both) throughout gestation-lactation; (3) short-term high-dose (100 14 administered 7 days pre/post-weaning farrowing. Our data indicate that antioxidants enhanced productive performance both piglets, with most pronounced effect observed in long-term, combined administration SOD. The composite significantly improved systemic antioxidant capacity sows, while concurrently reducing cortisol lipopolysaccharide concentrations serum. enhancement contributed elevations serum progesterone prolactin levels at day 40 farrowing, respectively, ultimately increasing number weaned decreasing backfat loss. In addition, compound indices increased growth hormone concentrations, litter weight gain. Mechanistically, placental upregulation CAT, GPX1, GLUT3, alongside Claudin1, Occludin, ZO-1 expression, underpinned nutrient transport barrier function. These findings demonstrate SOD synergistically transfer via colostrum pathways, offering viable strategy for integrated sow-piglet management.

Language: Английский

Citations

0
Facile Synthesis of Reduced Graphene Oxide using Streptomyces rochei Ra3: Characterization, Biological Applications and In Silico Analysis of Diabetes-Related Proteins DOI

Nithyalakshmi Mohanam,

Lokesh Elumalai,

Sivarajan Anbalmani

et al.

Waste and Biomass Valorization, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Copper Complexes with New Glycyl-l-histidyl-l-lysine–Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects DOI
Valentina Greco, Valeria Lanza, Barbara Tomasello

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

In recent years, hyaluronic acid (HA) and the natural tripeptide glycyl-l-histidyl-l-lysine (GHK), especially its copper(II) complex (GHK-Cu), individually have been shown to exert helpful properties for bone protection regeneration. However, they are not strong enough handle oxidative stress, hydrolytic attack, or environmental conditions. Being aware that conjugation chemistry has recently emerged as an appealing approach generating new molecular entities capable of preserving integrity their moieties delaying degradation, herein we present synthesis conjugates HA with GHK (GHK-HA), at different loadings tripeptide. GHK-HA binds ions potentiates chemical biological two components in vitro assays. The results highlight copper's role promoting expression release certain trophic, angiogenic, osteogenic factors, including brain-derived neurotrophic factor (BDNF), vascular endothelial growth (VEGF), well morphogenetic protein-2 (BMP-2). protective regenerative activities metal ion related translocation intracellular chaperones Copper Chaperone Superoxide Dismutase (CCS) Antioxidant-1 (Atox1) nucleus where act transcription factors.

Language: Английский

Citations

0