Salinity Influence on Mytilus galloprovincialis Exposed to Antineoplastic Agents: A Transcriptomic, Biochemical, and Histopathological Approach DOI Creative Commons
Vanessa Queirós, Carla Leite, Ulisses M. Azeiteiro

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125135 - 125135

Published: Oct. 18, 2024

Nowadays, aquatic species face a variety of environmental risks associated with pharmaceutical consumption. More specifically, the increased number cancer patients has been accompanied by an consumption antineoplastic drugs, such as ifosfamide (IF) and cyclophosphamide (CP). These drugs have found in ecosystems, raising concerns about their impact, especially on estuarine species, marine waters are final recipients continental effluents. Simultaneously, predicted climatic changes, salinity shifts, may threaten organisms. Considering this, present research aims to investigate combined effects IF CP, shifts. For transcriptomic, biochemical, histopathological assessment was made using bivalve Mytilus galloprovincialis exposed for 28 days CP (500 ng/L), individually, at different levels (20, 30, 40). up-regulated metabolism-related gene cyp3a1, also affecting abcc gene, showing minimal impact highlighting importance these metabolic routes mussels. Salinity shifts affected transcription genes related apoptosis cell cycle growth, p53, well aerobic metabolism, antioxidant biotransformation mechanisms. findings indicate mussels' high adaptability osmotic stress. Under exposure low salinity, mussels exhibited cellular damage digestive gland tubules, revealing detrimental towards M. galloprovincialis, suggesting that slowdown activation mechanisms helped prevent oxidative control salinities. Overall, results reinforce need antineoplastics ecotoxicological risk assessment, under foreseen climate change scenarios.

Language: Английский

Surviving global change: a review of the impacts of drought and dewatering on freshwater mussels DOI Creative Commons
Kiara C. Cushway, Juergen Geist, Astrid N. Schwalb

et al.

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

ABSTRACT The increase in the frequency and intensity of droughts heatwaves caused by climate change poses a major threat to biodiversity. In aquatic systems, sedentary species such as freshwater mussels are generally considered more vulnerable changes habitat conditions than mobile fish. As provide important ecosystem services, understanding impacts drought on is particular importance for management overall functioning ecosystems. We used comprehensive literature search systematic overview direct indirect effects (Bivalvia: Unionida) an evaluation mitigation strategies. found that studies were concentrated mostly USA, with focus Unionidae family. Topics ranged from physiological high temperatures, emersion, hypoxia/anoxia behavioural reproductive consequences implications biotic interactions services. Studies spanned all levels biological organization, individual responses population‐ community‐level ecosystem‐wide effects. identified several knowledge gaps, including paucity trait‐based consequences, limited thermal desiccation tolerance at level, synergistic multiple stressors mussels. Although we many provided suggestions concerning populations, conditions, anthropogenic water use, approach testing recommended strategies largely lacking, creating challenges managers aiming conserve mussel communities populations light change.

Language: Английский

Citations

1
Mussels with luggage: the influence of artificially attached “backpack” devices on mussel movement behavior DOI Creative Commons
Konstantina Drainas, Sebastian Beggel, Juergen Geist

et al.

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Aug. 13, 2024

Abstract Background Freshwater mussels are important keystone and indicator species of aquatic ecosystems. Recent advances in sensor technology facilitate applications to individually track record monitor their behavior physiology. These approaches require the attachment devices as “backpacks” outer shell surface. The interpretation such data makes it necessary understand influence these attachments on horizontal vertical movement behaviors freshwater mussels. Over a series mesocosm experiments, this study systematically investigated effects three size- wiring-specific variants artificially attached backpacks Anodonta anatina. Results Across all equipping with did not result significant for any backpack variants. In contrast finding, big high ratio between volume mussel length resulted significantly negative effect movement, indicating potential adverse mussels, especially natural settings. Conclusions findings show that assessing requires species-specific evaluation impacts endpoints interest. Especially patterns, selection smallest available appears mandatory.

Language: Английский

Citations

0
An Update on the Conservation Status Assessment of two Endangered Freshwater Mussel Species in Bavaria, Germany DOI Creative Commons
Andreas H. Dobler, Philipp Hoos, Juergen Geist

et al.

Aquatic Conservation Marine and Freshwater Ecosystems, Journal Year: 2024, Volume and Issue: 34(10)

Published: Oct. 1, 2024

ABSTRACT The two highly endangered European mussel species Margaritifera margaritifera and Unio crassus are target of conservation. Based on a recently completed systematic state‐wide monitoring each 22 M. U. streams in Bavaria, Germany, we present an update population trends, conservation status, habitat quality threats for both species. Populations status varied strongly between streams, but there was also great variability within those groups. decline has continued, albeit higher proportions juveniles originating from artificial breeding programmes have been established some streams. Habitat often did not match known requirements as evident poor stream bed quality, lack hosts elevated nutrient levels. In contrast, populations showed better with increase size over all sampled Successful recruitment indicated by high juveniles. However, no mussels older than 16 years were found, probably due to predation structural maintenance measures. Climate change effects, such extreme droughts, affected This study demonstrates different needs management Although mitigation drought effects is commonly needed species, tackling host fish direct should be prioritized , whereas restoration prime intact catchments key enable natural sustainable .

Language: Английский

Citations

0
Salinity Influence on Mytilus galloprovincialis Exposed to Antineoplastic Agents: A Transcriptomic, Biochemical, and Histopathological Approach DOI Creative Commons
Vanessa Queirós, Carla Leite, Ulisses M. Azeiteiro

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125135 - 125135

Published: Oct. 18, 2024

Nowadays, aquatic species face a variety of environmental risks associated with pharmaceutical consumption. More specifically, the increased number cancer patients has been accompanied by an consumption antineoplastic drugs, such as ifosfamide (IF) and cyclophosphamide (CP). These drugs have found in ecosystems, raising concerns about their impact, especially on estuarine species, marine waters are final recipients continental effluents. Simultaneously, predicted climatic changes, salinity shifts, may threaten organisms. Considering this, present research aims to investigate combined effects IF CP, shifts. For transcriptomic, biochemical, histopathological assessment was made using bivalve Mytilus galloprovincialis exposed for 28 days CP (500 ng/L), individually, at different levels (20, 30, 40). up-regulated metabolism-related gene cyp3a1, also affecting abcc gene, showing minimal impact highlighting importance these metabolic routes mussels. Salinity shifts affected transcription genes related apoptosis cell cycle growth, p53, well aerobic metabolism, antioxidant biotransformation mechanisms. findings indicate mussels' high adaptability osmotic stress. Under exposure low salinity, mussels exhibited cellular damage digestive gland tubules, revealing detrimental towards M. galloprovincialis, suggesting that slowdown activation mechanisms helped prevent oxidative control salinities. Overall, results reinforce need antineoplastics ecotoxicological risk assessment, under foreseen climate change scenarios.

Language: Английский

Citations

0