Comments on Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 44
Published: July 27, 2024
Thiophene,
a
heterocyclic
compound
characterized
by
five-membered
ring
comprising
four
carbon
atoms
and
one
sulfur
atom,
has
garnered
significant
attention
in
recent
research
due
to
its
versatile
applications
medicinal
chemosensing
fields.
Thiophene
derivatives
formed
complexes
with
various
transition
metals.
These
exhibit
promising
anti-inflammatory,
anticancer,
antibacterial,
antifungal
other
biological
properties.
Certainly,
the
complexation
phenomenon
involving
thiophene
can
be
effectively
used
for
recognition
of
cations.
Thiophene-based
compounds
act
as
selective
ligands,
forming
stable
specific
heavy
metal
ions.
This
property
implications
environmental
monitoring,
industrial
safety,
public
health,
presence
ions
beyond
permissible
levels
lead
detrimental
effects.
paper
explored
derivatives,
investigating
their
potential
determination
covering
period
from
2018
2024.
serve
ligands
fluorescence
colorimetric
changes
detection
Additionally,
this
study
also
explores
anticancer
efficacy
demonstrated
derived
thiophene,
emphasis
on
those
platinum-group
metals
(Ir(III),
Ru(II),
Ru(III),
Rh,
Os(II),
Os(IV),
Pd(II),
Pt(II)).
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 12, 2025
ABSTRACT
Four
ortho‐hydroxy
aromatic
bidentate
Schiff
bases
were
synthesized
along
with
the
corresponding
copper
(II)
complexes
and
characterized
by
various
analytical
methods.
The
spatial
configurations
of
metal
suggested
in
light
results
obtained.
Antibacterial
evaluations
revealed
that
ligands
more
active
than
their
Cu(II)
complexes.
study
antifungal
activity
showed
fungus
Candida
albicans
was
inhibited
(HL
3
HL
4
)
(IZ
=
25
mm).
According
to
evaluation
antioxidant
potency
DPPH
method,
only
ligand
demonstrated
a
comparatively
low
ability
scavenge
free
radicals
compared
ascorbic
acid
reference.
Using
AutoDock
4.2
program,
molecular
docking
investigations
conducted
aim
predicting
structure–activity
relationship
for
antibacterial
qualities.
sites
receptor
proteins,
evaluated
assays.
A
good
correlation
found
between
experimental
data.
