Green Processing and Synthesis,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
Silver
nanoparticles
(AgNPs)
are
extensively
studied
as
potent
antibacterial
agents
targeting
antibiotic-resistant
pathogens.
Cellular
damage
induced
through
various
mechanisms
that
can
affect
multiple
cell
components
like
the
outer
membrane,
enzymes,
and
proteins
is
closely
linked
to
their
chemical
morphological
characteristics.
We
investigated
impact
of
AgNPs’
size
on
effectiveness
using
two
differently
sized
nanoparticles:
silver
nanoparticle-
Citrus
limon
(AgCL)
with
an
average
21
nm
sinensis
(AgCS)
13
nm,
derived
from
C.
environmentally
friendly
methods.
The
study
evaluated
effects
by
assessing
morphology
changes
via
scanning
electron
microscopy,
metabolic
alterations
Fourier
transform
infrared
(FT-IR)
spectroscopy,
oxidative
stress
responses
biochemical
markers
in
Klebsiella
pneumoniae
cells
exposed
AgNPs.
results
showed
both
AgCL
AgCS
exhibited
remarkable
activity,
evidenced
inhibition
zones
14
±
1.5
16
1.0
mm,
respectively.
Morphological
K.
treated
AgNPs
were
dependent,
notable
noted.
FT-IR
spectroscopy
revealed
concentration-dependent
changes,
particularly
shifts
functional
groups
involved
fluidity
wall
lipid,
protein
structure.
Exposure
led
increased
lipid
peroxides
reduced
levels
enzymatic
non-enzymatic
antioxidants,
more
prominently
observed
smaller
(13
nm).
induce
strains,
demonstrating
greater
efficacy.
These
findings
underscore
importance
nanoparticle
optimizing
properties
against
Nanotoxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 36
Published: Jan. 30, 2025
The
mouth
cavity
is
the
second
most
complex
microbial
community
in
human
body.
It
composed
of
bacteria,
viruses,
fungi,
and
protozoa.
An
imbalance
oral
microbiota
may
lead
to
various
conditions,
including
caries,
soft
tissue
infections,
periodontitis,
root
canal
peri-implantitis
(PI),
pulpitis,
candidiasis,
denture
stomatitis.
Additionally,
several
locally
administered
antimicrobials
have
been
suggested
for
dentistry
surgical
non-surgical
applications.
main
drawbacks
are
increased
antimicrobial
resistance,
risk
upsetting
natural
microbiota,
hypersensitivity
responses.
Because
their
unique
physiochemical
characteristics,
nanoparticles
(NPs)
can
circumvent
antibiotic-resistance
mechanisms
exert
action
via
a
variety
new
bactericidal
routes.
anti-microbial
properties,
carbon-based
NPs
becoming
more
effective
antibacterial
agents.
Periodontitis,
PI,
dentin
other
dental
diseases
among
conditions
that
be
treated
using
carbon
(CNPs)
like
graphene
oxide
dots.
outline
scientific
development
multifunctional
CNPs
concerning
disorders
will
given
before
talking
about
significant
influence
on
health.
Some
these
illnesses
include
pulp
disorders,
PI.
We
also
review
remaining
research
application
barriers
possible
future
problems.
Antibiotic
resistance
is
a
critical
global
public
health
challenge
driven
by
the
limited
discovery
of
antibiotics,
rapid
evolution
mechanisms,
and
persistent
infections
that
compromise
treatment
efficacy.
Combination
therapies
using
antibiotics
nanoparticles
(NPs)
offer
promising
solution,
particularly
against
multidrug-resistant
(MDR)
bacteria.
This
study
introduces
an
innovative
approach
to
identifying
synergistic
drug–NP
combinations
with
enhanced
antimicrobial
activity.
To
carry
this
out,
we
compiled
two
groups
data
sets
predict
minimal
concentration
(MC)
zone
inhibition
(ZOI)
various
combinations.
CatBoost
regression
models
achieved
best
10-fold
cross-validation
R2
scores
0.86
0.77,
respectively.
We
then
adopted
machine
learning
(ML)-reinforced
genetic
algorithm
(GA)
identify
NPs.
The
proposed
was
first
validated
reproducing
previous
experimental
results.
As
proof
concept
for
discovering
combinations,
Au
NPs
were
identified
as
highly
when
paired
chloramphenicol,
achieving
minimum
bactericidal
(MBC)
71.74
ng/mL
Salmonella
typhimurium
fractional
inhibitory
index
6.23
×
10–3.
These
findings
present
effective
strategy
providing
combating
drug-resistant
pathogens
advancing
targeted
therapies.
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY,
Journal Year:
2025,
Volume and Issue:
unknown, P. 291 - 302
Published: March 20, 2025
Background:
With
the
increase
in
incidence
of
peri-implant
complications,
development
implant
surface
coatings
focused
on
improving
osseointegration
is
need
hour.
The
aim
this
study
was
and
characterization
selenium
conversion
titanium
dental
implants,
representing
an
innovative
approach
to
enhancing
osseointegration.
Materials
methods:
A
0.1
M
solution
sodium
selenite
prepared
by
dissolving
it
deionized
water,
with
pH
adjusted
4
using
phosphoric
acid.
Titanium
implants
were
cleaned,
etched
10%
hydroxide,
immersed
for
1
hour
agitation.
coated
rinsed,
dried,
characterized
Scanning
Electron
Microscope
(SEM),
Energy
Dispersive
X-ray
(EDX),
Fourier
Transform
Infrared
Spectroscopy
(FTIR),
biocompatibility,
corrosion
analysis.
Student’s
independent
t-test
performed
compare
biocompatibility
coating-based
(Group
A)
versus
bare
B)
at
24,
48,
72,
96,
120
hours.
Results:
Material
revealed
successful
coating
that
appeared
as
a
generalized
rough
spherical
agglomerates.
proved
its
greatest
percentage
cell
viability
noted
24
hours
p-value
0.653.
No
statistically
significant
difference
among
both
Groups
B
relation
biocompatibility.
Corrosion
analysis
be
thermodynamically
stable
good
resistance
properties.
Conclusion:
developed
has
proven
potential
exploration
dependable
coating.
Additionally,
extended
vivo
studies
are
needed
validate
clinical
effectiveness.
