Simulation of transvascular transport of nanoparticles in tumor microenvironments for drug delivery applications DOI Creative Commons

Fariha Shabbir,

Amenah Abdul Mujeeb, Syed Faraz Jawed

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 20, 2024

Nanomedicine is a promising approach for tumor therapy but penetration challenged by complex microenvironments. The purpose of this study to design nanoparticles and analyze their transport in two abnormal microenvironments through 2-D simulation. Employing Computational Fluid Dynamics (CFD) approach, vascular-interstitial models were initially simulated, the impact on velocity profile pressure gradient within microenvironment was observed. Through meticulous mesh analysis, it determined that optimal outcomes achieved using quadrilateral meshing method pancreatic quad/tri hepatic tumor. Results showed an increase vessel diameter correlated with elevated blood flow velocity, reaching maximum 1.40 × 10^-3 m/s expanding cell gap. simulation results distribution show as increases, increases decreases blood. Intriguingly, distinct fluid patterns tumors, emphasize how microenvironmental differences, specifically pore size, profoundly therapeutic agent transport, implications drug delivery strategies cancer therapy. These simulation-based insights enable researchers anticipate nanofluid behavior realistic settings. Future work, incorporating immune cells, will enhance understanding nanoparticle efficiency

Language: Английский

Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review DOI Creative Commons

Alshayma N. Al-Thani,

Asma Ghafoor Jan,

Mohamed Abbas

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

Citations

82
Nanoparticle-based drug delivery systems targeting cancer cell surfaces DOI Creative Commons

Liquan Hong,

Wen Li, Yang Li

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21365 - 21382

Published: Jan. 1, 2023

This review focuses on the research progress of various receptors overexpressed surface cancer cells and different nano-delivery systems anticancer drugs targeted cells.

Language: Английский

Citations

71
Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives DOI Creative Commons
Sagnik Nag, Oishi Mitra, G. Tripathi

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103959 - 103959

Published: Jan. 21, 2024

Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.

Language: Английский

Citations

62
Recent Insights into Nanotechnology in Colorectal Cancer DOI
Aram Asareh Zadegan Dezfuli, Mohammed Abu‐Elghait, Salem S. Salem

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2023, Volume and Issue: 196(7), P. 4457 - 4471

Published: Sept. 26, 2023

Language: Английский

Citations

33
Exploring the integration of nanotechnology in the development and application of biosensors for enhanced detection and monitoring of colorectal cancer DOI
Ashkan Hajjafari, Soheil Sadr, Abbas Rahdar

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 164, P. 112409 - 112409

Published: April 12, 2024

Language: Английский

Citations

18
Green tea-mediated synthesis of silver nanoparticles: Enhanced anti-cancer activity and reduced cytotoxicity melanoma and normal murine cell lines DOI
Monireh Golpour, Pedram Ebrahimnejad, Zahra Rezanejad Gatabi

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 161, P. 111989 - 111989

Published: Jan. 24, 2024

Language: Английский

Citations

13
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability DOI Creative Commons
Martin Bravo, Beatrice Fortuni, Paul Mulvaney

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 751 - 777

Published: July 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

Citations

11
Spinach to the Rescue: Unveiling the Antibacterial and Anticancer Potential of Biogenic Zinc-Doped Hydroxyapatite Nanoparticles DOI

K. Arun,

G. Shobana,

V. Gayathri

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

2
Evaluation of biogenically synthesized MgO NPs anticancer activity against breast cancer cells DOI Creative Commons

Mohammad Rashid Khan,

Nouf Omar Alafaleq, Arun Kumar Ramu

et al.

Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 31(1), P. 103874 - 103874

Published: Nov. 11, 2023

Magnesium is recognized to have pharmacological potential, and its nanoformulation anticipated offer significant therapeutic effects, particularly against cancer. In this study, we analyzed the anticancer effect of biogenically synthesized magnesium oxide nanoparticles (MgO NPs) breast cancer cells (MDA-MB-231). Different biological evaluations, such as cytotoxicity, cellular morphology, induction apoptosis, generation ROS, cell adhesion migration were estimated using well established methodology. The biogenic MgO NPs exhibited increased induced formation promoted inhibited in a dose-dependent manner, showing potential MDA-MB-231cells. current study observed strong activity studied lines. However, our must be validated an appropriate animal/xenograft model authenticate effectiveness

Language: Английский

Citations

23
Novel Lipid Nanoparticles Stable and Efficient for mRNA Transfection to Antigen-Presenting Cells DOI Open Access

Kang Chan Choi,

Do Hyun Lee, Ji‐Won Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1388 - 1388

Published: Jan. 23, 2024

mRNA vaccines have emerged as a pivotal tool in combating COVID-19, offering an advanced approach to immunization. A key challenge with these is their need for extremely-low-temperature storage, which affects stability and shelf life. Our research addresses this issue by enhancing the of through novel cationic lipid, O,O′-dimyristyl-N-lysyl aspartate (DMKD). DMKD effectively binds mRNA, improving vaccine stability. We also integrated phosphatidylserine (PS) into formulation boost immune response promoting uptake nanoparticles cells. findings reveal that DMKD-PS maintain structural integrity under long-term refrigeration protect mRNA. When tested, containing green fluorescent protein (GFP) outperformed other commercial lipid expression, both cells (RAW 264.7 mouse macrophage) non-immune (CT26 colorectal carcinoma cells). Importantly, vivo studies show are safely eliminated from body within 48 h. The results suggest present promising alternative delivery, effectiveness vaccines.

Language: Английский

Citations

8