Journal of Education Health and Sport,
Journal Year:
2024,
Volume and Issue:
59, P. 126 - 144
Published: Feb. 13, 2024
Introduction:
Polyphenolic
compounds
are
widespread
in
nature,
contained
large
quantities
especially
fruits,
vegetables,
cereals
and
nuts.
In
recent
years
numerous
attempts
have
been
made
to
characterize
their
biological
effects,
with
particular
emphasis
on
protective
potential
against
the
development
of
chronic
diseases,
including
cancer.
Purpose
study:
The
aim
study
was
collect
analyze
publications
use
polyphenols
prevention
treatment
cancer,
breast
colon
prostate
cancer
lung
-
four
most
common
cancers
Polish
population.
Material
methods:
A
review
literature
available
PubMed
performed
using
various
combinations
keywords:
'polyphenols'
+
'cancer',
'oncology',
‘polyphenols’
‘chemoprevention’,
‘chemotherapy’,
'lung
cancer',
'breast
‘colorectal
cancer’,
'prostate
cancer'/'prostate
gland
cancer'.
Results:
analysis
collected
allows
conclude
that
exert
multidirectional
anticancer
effect
through
antioxidant,
antiproliferative,
anti-inflammatory,
immunomodulatory
prosenescence
activity.
This
has
demonstrated,
among
others,
relation
cellular
models
colorectal
cervical
cancer.
Polyphenols
also
reduce
side
effects
associated
conventional
therapies
increase
effectiveness.
Conclusions:
both
as
independent
components
complex
regimens
chemopreventive
potentially
chemotherapeutic
effects.
By
influencing
stages
carcinogenesis
initiation,
promotion
progression
they
constitute
a
promising
direction
for
new,
more
effective
forms
therapy
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11003 - 11003
Published: Oct. 13, 2024
Zearalenone
(ZEA)
is
a
mycotoxin
produced
by
Fusarium
spp.
fungi
and
widely
found
in
moldy
corn,
wheat,
barley,
other
grains.
ZEA
distributed
to
the
whole
body
via
blood
circulation
after
metabolic
transformation
animals.
Through
oxidative
stress,
immunosuppression,
apoptosis,
autophagy,
mitochondrial
dysfunction,
leads
hepatitis,
neurodegenerative
diseases,
cancer,
abortion,
stillbirth
female
animals,
decreased
sperm
motility
male
In
recent
years,
due
influence
of
climate,
storage
facilities,
factors,
problem
pollution
global
food
crops
has
become
particularly
prominent,
resulting
serious
problems
for
animal
husbandry
feed
industries,
threatening
human
health.
Resveratrol
(RSV)
natural
product
with
therapeutic
activities
such
as
anti-inflammatory,
antioxidant,
anticancer
properties.
RSV
can
alleviate
ZEA-induced
toxic
effects
targeting
signaling
pathways
NF-κB,
Nrf2/Keap1,
PI3K/AKT/mTOR
attenuating
damage,
inflammatory
response,
regulating
cellular
autophagy.
Therefore,
this
paper
provides
review
protective
effect
against
toxicity
its
molecular
mechanism,
discusses
safety
potential
clinical
applications
search
detoxification
agents.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(46), P. 63170 - 63185
Published: Nov. 8, 2024
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
that
can
result
in
paralysis.
After
SCI
occurs,
the
blood–spinal
barrier
(BSCB)
disrupted,
and
permeability
transiently
elevated.
However,
of
BSCB
returns
to
normal
over
time,
which
prevents
many
drugs
from
being
used
subsequent
treatments.
In
this
study,
we
designed
borneol-functionalized
macrophage
membrane
encapsulating
mesoporous
selenium
nanoparticles
loaded
with
resveratrol
(MSe-Res-BMMs)
for
treatment.
vivo
animal
experiments
vitro
cell
demonstrated
MSe-Res-BMMs
were
able
protect
neurons
ferroptosis
by
reducing
ROS
levels
increasing
glutathione
peroxidase-4
(GPx-4)
activity.
addition,
treatment
also
reduced
ROS-induced
inflammation
apoptosis
decreasing
expression
inflammatory
factor
IL-1β
apoptotic
Cleaved
Caspase-3
at
site
injury.
Therefore,
are
expected
provide
new
therapeutic
options
Nutrition and Cancer,
Journal Year:
2024,
Volume and Issue:
76(9), P. 760 - 788
Published: July 1, 2024
The
resistance
of
colorectal
cancer
(CRC)
to
conventional
therapeutic
modalities,
such
as
radiation
therapy
and
chemotherapy,
along
with
the
associated
side
effects,
significantly
limits
effective
anticancer
strategies.
Numerous
epigenetic
investigations
have
unveiled
that
naturally
occurring
stilbenes
can
modify
or
reverse
abnormal
alterations,
particularly
aberrant
DNA
methylation
status,
offering
potential
avenues
for
preventing
treating
CRC.
By
modulating
activity
machinery
components,
phytochemicals
may
influence
various
stages
CRC
carcinogenesis
through
multiple
molecular
mechanisms.
Several
studies,
especially
preclinical
research,
highlighted
modulatory
effects
minimal
adverse
on
organisms,
in
combination
therapies
However,
available
clinical
data
regarding
commonly
encountered
against
are
currently
limited.
Therefore,
additional
research
is
warranted
explore
preventive
these
development
validate
their
application
prevention
treatment
This
review
aims
provide
an
overview
selected
bioactive
chemopreventive
agents
a
focus
mechanisms
action,
targeting
alterations
Journal of Education Health and Sport,
Journal Year:
2024,
Volume and Issue:
59, P. 126 - 144
Published: Feb. 13, 2024
Introduction:
Polyphenolic
compounds
are
widespread
in
nature,
contained
large
quantities
especially
fruits,
vegetables,
cereals
and
nuts.
In
recent
years
numerous
attempts
have
been
made
to
characterize
their
biological
effects,
with
particular
emphasis
on
protective
potential
against
the
development
of
chronic
diseases,
including
cancer.
Purpose
study:
The
aim
study
was
collect
analyze
publications
use
polyphenols
prevention
treatment
cancer,
breast
colon
prostate
cancer
lung
-
four
most
common
cancers
Polish
population.
Material
methods:
A
review
literature
available
PubMed
performed
using
various
combinations
keywords:
'polyphenols'
+
'cancer',
'oncology',
‘polyphenols’
‘chemoprevention’,
‘chemotherapy’,
'lung
cancer',
'breast
‘colorectal
cancer’,
'prostate
cancer'/'prostate
gland
cancer'.
Results:
analysis
collected
allows
conclude
that
exert
multidirectional
anticancer
effect
through
antioxidant,
antiproliferative,
anti-inflammatory,
immunomodulatory
prosenescence
activity.
This
has
demonstrated,
among
others,
relation
cellular
models
colorectal
cervical
cancer.
Polyphenols
also
reduce
side
effects
associated
conventional
therapies
increase
effectiveness.
Conclusions:
both
as
independent
components
complex
regimens
chemopreventive
potentially
chemotherapeutic
effects.
By
influencing
stages
carcinogenesis
initiation,
promotion
progression
they
constitute
a
promising
direction
for
new,
more
effective
forms
therapy
