Downregulation of KLF5 by EBER1 via the ERK signaling pathway in EBV-positive nasopharyngeal carcinoma cells: implications for latent EBV infection

Journal of General Virology, Journal Year: 2024, Volume and Issue: 105(5)

Published: May 15, 2024

Nasopharyngeal carcinoma (NPC) carcinogenesis and malignant transformation are intimately associated with Epstein-Barr virus (EBV) infection. A zinc-fingered transcription factor known as Krüppel-like 5 (KLF5) has been shown to be aberrantly expressed in a number of cancer types. However, little is about the regulatory pathways roles KLF5 EBV-positive NPC. Our study found that expression was significantly lower NPC than EBV-negative Further investigation revealed EBER1, which encoded by EBV, down-regulates via extracellular signal-regulated kinase (ERK) signalling pathway. This down-regulation EBER1 contributes maintaining latent EBV infection Furthermore, we uncovered biological cells. Specifically, may influence cell cycle, prevent apoptosis, encourage migration proliferation – all have generally pro-cancer impact. In conclusion, these findings offer novel strategies for patients’ antitumour treatment.

Language: Английский

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PD-1 inhibitors combined with chemotherapy versus chemotherapy alone: efficacy and prognostic analysis in recurrent metastatic nasopharyngeal carcinoma

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(6), P. 2622 - 2632

Published: Jan. 1, 2024

To evaluate the prognostic value of combining PD-1 inhibitors (toripalimab or karelizumab) with chemotherapy for treating recurrent metastatic nasopharyngeal carcinoma (R/M NPC).

Language: Английский

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Metabolic reprogramming in the pathogenesis and progression of nasopharyngeal carcinoma: molecular mechanisms and therapeutic implications

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 4049 - 4064

Published: Jan. 1, 2024

Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with complex etiology involving genetic predispositions, environmental factors, Epstein-Barr virus (EBV) infection. Despite progress in radiotherapy chemotherapy, the prognosis for advanced NPC still unfavorable, prompting need innovative therapeutic approaches. Metabolic reprogramming plays crucial role development progression of NPC, marked by substantial changes glycolysis, lipid, amino acid metabolism. These alterations aid tumor cell proliferation, survival under stress, immune evasion, features such as enhanced aerobic glycolysis (Warburg effect) shifts lipid pathways. Oncogenic drivers like MYC, RAS, EGFR, loss suppressors TP53 PTEN, along key signaling pathways including mTOR, AMPK, HIF-1α, orchestrate these metabolic changes. This review discusses molecular mechanisms outlines potential targets within Advances imaging biomarker discovery are also enhancing precision diagnostics treatment monitoring, fostering personalized medicine treatment. manuscript aims to provide detailed overview current research its implications improving management patient outcomes through targeted therapies.

Language: Английский

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Association of Lymphocyte Subsets Percentage with Prognosis for Recurrent or Metastatic Nasopharyngeal Carcinoma Patients Receiving PD-L1 Inhibitors

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Background: Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 inhibitors, have demonstrated significant survival benefits in treating recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC). While baseline peripheral blood lymphocyte subsets been identified as prognostic biomarkers various cancers treated with ICIs, their relevance R/M-NPC has not extensively studied. Methods: This post-hoc analysis used data from 153 patients PD-L1 inhibitor monotherapy the phase 2 trial KL167-2-05-CTP. The subsets, including total T cells, CD4/CD8 ratio, helper suppressor cytotoxic NK and B were tested by flow cytometry. These grouped using optimal cutoff values Maximally Selected Log-rank Statistic. Overall (OS) progression-free (PFS) assessed Kaplan-Meier Cox regression analysis, logistic evaluated associations objective response rate (ORR) disease control (DCR). Results: Patients lower cell percentages showed significantly longer OS (26.3 vs. 12.1 months, p<0.001) PFS (5.5 3.7 compared to those higher percentages. No differences observed for other subsets. High risk factors shorter (HR, 2.49) 1.62). There no ORR DCR between high low Conclusion: Lower are associated improved undergoing therapy.

Language: Английский

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The protective role of vitamin d in nasopharyngeal carcinoma: insights from Mendelian randomization and meta-analysis

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 9, 2024

In recent years, the anti-tumor effects of vitamin D have garnered increasing attention. However, previous epidemiological studies on relationship between and nasopharyngeal carcinoma (NPC) yielded inconsistent results. This study aims to further explore whether helps reduce risk NPC through Mendelian randomization (MR) meta-analysis.

Language: Английский

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