Meeting Review: “National Cancer Institute Conference on Cancer Bioelectricity” September 12, 2024

Bioelectricity, Journal Year: 2025, Volume and Issue: 7(1), P. 94 - 104

Published: Feb. 17, 2025

The Office of Cancer Complementary and Alternative Medicine, part the Division Treatment Diagnosis under National Institute (NCI), supports research in diverse areas cancer therapeutics such as microbial therapies, herbal remedies, mind–body practices. Recently they have become especially interested emerging role bioelectricity biology organized a virtual meeting with some top scientists field. In this report, we overview first-of-its-kind Naional Health (NIH)-sponsored meeting, which featured talks from 14 researchers exploring biology. covered wide range topics, including excellent background information on how cell collectives change their bioelectrical coupling set points during formation, new tools for reading writing signatures cells whole organisms, ion channels that are involved setting those affect canonical pathways development tumor growth, methods modeling interactions transfer collectives. Especially exciting were translational technologies highlighted, diagnostics, metastasis inhibition more efficient detection surgical margins. concluded funding opportunities available NCI Biology, Innovative Molecular Analysis Technologies Program, Small Business Innovation Research Development Center.

Language: Английский

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An Inverse Relationship Between Dementia and Cancer Incidence: Could This be Another Facet of “Cancer Neuroscience”?

Bioelectricity, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

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Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies

The Journal of Membrane Biology, Journal Year: 2024, Volume and Issue: 257(5-6), P. 281 - 305

Published: Aug. 25, 2024

Language: Английский

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Potential Shortcomings of Genomic Database: The Case of Na_v1.5 Expression in Breast Cancer

Bioelectricity, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Language: Английский

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Stemness of Cancer: A Study of Triple-negative Breast Cancer From a Neuroscience Perspective

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Stemness, giving cancer cells massive plasticity enabling them to survive in dynamic (e.g. hypoxic) environments and become resistant treatment, especially chemotherapy, is an important property of aggressive tumours. Here, we review some essentials stemness focusing on triple-negative breast (TNBC), the most form all cancers. TNBC express a range genes mechanisms associated with stemness, including fundamental four “Yamanaka factors”. Most evidence concerns transcription factor / oncogene c-Myc interesting case expression neonatal splice variant voltage-gated sodium channel subtype Nav1.5. On whole, measures that reduce make less aggressive, reducing their invasive/metastatic potential increasing/restoring chemosensitivity. Such include gene silencing techniques, epigenetic therapies as well novel approaches like optogenetics aiming modulate plasma membrane voltage. Indeed, simply hyperpolarizing can stem differentiate. Finally, give overview clinical aspects exploitation cancer/TNBC diagnostics therapeutics. In particular, personalised mRNA-based mechanistically meaningful combinations are promising emerging discipline ‘cancer neuroscience’ providing insights both issues applications. Graphical

Language: Английский

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The Problem of Diagnosing Prostate Cancer—The Promise of Ion Channels as Novel Biomarkers of Disease!

Bioelectricity, Journal Year: 2024, Volume and Issue: 7(1), P. 76 - 77

Published: Nov. 28, 2024

Language: Английский

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