A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1551 - 1551

Published: Feb. 12, 2025

Mitophagy plays a critical role in maintaining mitochondrial quality and cellular homeostasis. But the specific contribution of mitophagy-related E3 ubiquitin ligases to prognoses remains largely unexplored. In this study, we identified novel ligase prognostic signature using least absolute shrinkage selector operator (LASSO) multivariate Cox regression analyses breast cancer. Based on median risk scores, patients were divided into high-risk low-risk groups. Functional enrichment conducted explore biological differences between two Immune infiltration, drug sensitivity, mitochondrial-related phenotypes also analyzed evaluate clinical implications model. A four-gene (ARIH1, SIAH2, UBR5, WWP2) was identified, Kaplan-Meier analysis demonstrated that group had significantly worse overall survival (OS). The exhibited disrupted metabolism immune dysregulation with upregulated checkpoint molecules. Additionally, higher sensitivity several drugs targeting Akt/PI3K/mTORC1 signaling axis. Accompanying metabolic dysregulation, mtDNA stress elevated, contributing activation senescence-associated secretory phenotype (SASP) group. conclusion, provides robust tool for stratification offers insights interplay mitophagy, modulation, therapeutic responses

Language: Английский

Functional Nucleic Acid Nanostructures for Mitochondrial Targeting: The Basis of Customized Treatment Strategies

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1025 - 1025

Published: Feb. 24, 2025

Mitochondria, as vital organelles, play a central role in subcellular research and biomedical innovation. Although functional nucleic acid (FNA) nanostructures have witnessed remarkable progress across numerous biological applications, strategies specifically tailored to target mitochondria for molecular imaging therapeutic interventions remain scarce. This review delves into the latest advancements leveraging FNA mitochondria-specific cancer therapy. Initially, we explore creation of FNA-based biosensors localized mitochondria, enabling real-time detection visualization critical molecules essential mitochondrial function. Subsequently, examine developments aimed at mitochondrial-targeted treatments, including modular nanodevices precise delivery agents programmable disrupting processes. Emphasis is placed on elucidating chemical principles underlying design mitochondrial-specific nanotechnology diverse uses. Lastly, address unresolved challenges outline prospective directions, with goal advancing field encouraging sophisticated tools both academic inquiry clinical applications centered mitochondria.

Language: Английский

Exploring the Potential of Mitochondria‐Targeted Drug Delivery for Enhanced Breast Cancer Therapy

International Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Breast cancer stands as the utmost prevalent malignancy in women, impacting epithelial tissue of breast and often displaying resistance to effective treatment due its diverse molecular histological features. Current modalities may exhibit decreasing efficacy over time can lead disease progression. The mitochondria, a crucial organelle responsible for cellular metabolism energy supply, stand highly sensitive both heat reactive oxygen species, presenting an assuring target photodynamic photothermal therapies (PTTs) cure. employment nanodrug carriers combination deliveries holds promise addressing challenges related drug degradation off-target toxicity. By circumventing reticuloendothelial system, nanocarriers bolster drug's bioavailability at intended site ensure controlled codelivery multiple drugs, thereby maintaining normal pharmacokinetic features regular pharmacodynamic characteristics different therapeutic mechanisms. precision this innovative technology have revolutionized delivery, substantially enhancing effectiveness. In pursuit targeting mitochondrial modifications cells, various such therapy (PDT), PTT, chemodynamic (CDT) been explored. These improved efficiency mitochondria-targeted their advantageous properties minimal toxicity, noninvasiveness, reduced resistance, safer profile. Our review article provides exhaustive overview alterations environment BC, impact on BC development, potential targets treatment, nanotherapeutic approaches limitations these approaches.

Language: Английский