Published: Jan. 1, 2024

Poly (lactic-co-glycolic acid) (PLGA) is widely used in bone repair due to its good controlled degradation. However, hydrophobicity, acidic products during degradation and insufficient osteogenic capacity limit application repair. In this study, we developed a PLGA composite containing Mg(OH)2 Zn3(PO4)2 with the aim balance improve anti-inflammatory properties capacity. The physicochemical properties, behavior, antimicrobial ability, vitro biological of composites were systematically investigated. results showed that addition effectively neutralized microenvironment composites, moderate amount had little effect on but an excessive accelerated composites. provided excellent ability. appropriate amounts magnesium could promote proliferation adhesion osteoblasts expression osteogenesis-related genes. have demonstrated great potential orthopedic applications PLGA/Mg(OH)2/Zn3(PO4)2

Language: Английский