The role of RNA binding proteins in cancer biology: A focus on FMRP DOI Creative Commons
Yunlu Jia,

Ruyin Jia,

Yongxia Chen

et al.

Genes & Diseases, Journal Year: 2024, Volume and Issue: 12(4), P. 101493 - 101493

Published: Dec. 22, 2024

RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such RNA splicing, transport, localization, stability, and translation through their specific binding to molecules. The diversity complexity RBPs are particularly significant in cancer biology, they directly impact a multitude metabolic events closely associated with tumor initiation progression. fragile X mental retardation protein (FMRP), member the RBP family, is central neurodevelopmental disorder syndrome increasingly recognized modulation biology its influence on metabolism. protein's versatility, stemming from diverse domains, enables it govern wide array transcript processing events. Modifications FMRP's or localization have been regulation mRNAs linked various pertinent cancer, including proliferation, metastasis, epithelial-mesenchymal transition, cellular senescence, chemotherapy/radiotherapy resistance, immunotherapy evasion. In this review, we emphasize recent findings analyses that suggest contrasting functions family tumorigenesis. Our knowledge regulated by FMRP rapidly growing, has led identification multiple targets for therapeutic intervention some which already moved into clinical trials practice.

Language: Английский

Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Language: Английский

Citations

1
Implication of protein post translational modifications in gastric cancer DOI Creative Commons

Houji Song,

Mingze Zhang, Chengwang Guo

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, its occurrence development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) forms include ubiquitylation, phosphorylation, acetylation methylation. Emerging research has highlighted lactylation glycosylation. The diverse realm PTM crosstalk linked to many critical signaling events involved in neoplastic transformation, carcinogenesis metastasis. This review provides a comprehensive overview impact on progression GC. Specifically, aberrant have been shown alter proliferation, migration, invasion capabilities GC cells. Moreover, closely associated with resistance chemotherapeutic agents Notably, this also discusses phenomenon crosstalk, highlighting interactions among their roles regulating pathways protein functions. Therefore, in-depth investigation into mechanisms targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, prognostic evaluation GC, offering novel insights future directions.

Language: Английский

Citations

0
Role of long non-coding RNAs in the regulation of ferroptosis in tumors DOI Creative Commons

Ying Ju,

Yuanhao Lv,

Xu Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Normal cells begin to grow indefinitely and immortalize form tumor after an external stimulus resulting in a genetic mutation. Effective killing of is the basis various cancer therapies. Ferroptosis class cell death types dependent on iron cellular lipid peroxidation. Tumors themselves are iron-dependent, conventional radiotherapy also sensitizes ferroptosis. Increasing sensitivity ferroptosis may be potential therapeutic strategy overcome resistance mechanisms therapy. Long noncoding RNAs (LncRNAs) transcripts more than 200 nucleotides length that regulate gene expression at multiple levels involved biological processes such as differentiation, cycle arrest, maintenance stemness. Recent studies have found lncRNAs through influence or ameliorate chemotherapeutic agents. With continuous maturation nanomaterials technology, it provide new means for treatment by regulating ferroptosis-related inside tumors well increasing Fe 2+ ROS tumors. In this paper, we systematically introduce regulatory mechanism ferroptosis, role immunotherapy application combined with nanomaterials, which provides perspectives

Language: Английский

Citations

0
Role of fragile sites FATS and FMR1 in tumor progression and their potential clinical significance DOI

Chuangdong Ruan,

Yichun Xie,

Huabin Ye

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract The fragile sites are defined as specific segments of genes that particularly susceptible to breakage under conditions accelerated replication stress or certain external influences. It has been demonstrated can influence the progression various tumors. However, majority existing studies have focused on functions well‐characterized common sites, such FHIT , WWOX and PARK2 in different oncogenic processes, with insufficient attention directed towards other sites. This article presents an analysis recent investigations into site‐associated tumor suppressor ( FATS ) X mental retardation 1 FMR1 ), across types. discusses mechanisms signaling pathways regulated by these a range cancers, well their clinical implications for treatment. review highlights significance cancers relevance.

Language: Английский

Citations

0
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs DOI Creative Commons
Shikai Wang, Zhipeng Li,

Yunxiang Chang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 14, 2025

Language: Английский

Citations

0
Advances in understanding the role of lncRNA in ferroptosis DOI Creative Commons
Yating Wen,

Wenbo Lei,

Jie Zhang

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17933 - e17933

Published: Aug. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Language: Английский

Citations

1
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac DOI
Shengwei Zhuang,

Zhekun Huang,

Hongkai Fan

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Sept. 13, 2024

This study investigated the role of lncRNA

Language: Английский

Citations

1
Multi-Dimensional Analysis of the Regulatory Network of Ferroptosis in Osteoarthritis: Progress, Challenges, and Future Directions DOI

Shenglin Xia,

Ziliang Wang,

Yu He

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Progress in research of ferroptosis in gastrointestinal tumors DOI Open Access

Zhao-Chun Chi

Shijie huaren xiaohua zazhi, Journal Year: 2024, Volume and Issue: 32(10), P. 699 - 715

Published: Oct. 28, 2024

Language: Английский

Citations

0
The role of RNA binding proteins in cancer biology: A focus on FMRP DOI Creative Commons
Yunlu Jia,

Ruyin Jia,

Yongxia Chen

et al.

Genes & Diseases, Journal Year: 2024, Volume and Issue: 12(4), P. 101493 - 101493

Published: Dec. 22, 2024

RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such RNA splicing, transport, localization, stability, and translation through their specific binding to molecules. The diversity complexity RBPs are particularly significant in cancer biology, they directly impact a multitude metabolic events closely associated with tumor initiation progression. fragile X mental retardation protein (FMRP), member the RBP family, is central neurodevelopmental disorder syndrome increasingly recognized modulation biology its influence on metabolism. protein's versatility, stemming from diverse domains, enables it govern wide array transcript processing events. Modifications FMRP's or localization have been regulation mRNAs linked various pertinent cancer, including proliferation, metastasis, epithelial-mesenchymal transition, cellular senescence, chemotherapy/radiotherapy resistance, immunotherapy evasion. In this review, we emphasize recent findings analyses that suggest contrasting functions family tumorigenesis. Our knowledge regulated by FMRP rapidly growing, has led identification multiple targets for therapeutic intervention some which already moved into clinical trials practice.

Language: Английский

Citations

0