An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases DOI Creative Commons
Xiangrong Cui, Huihui Li,

Xia Huang

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

N6-methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing pivotal role various biological functions. Its significance female reproductive development associated diseases has recently become focal point of research.

Language: Английский

Citations

1
Inhibition of SENP5 reduces brain injury in TBI rats by regulating NEDD4L/TCF3 axis DOI

Minjun Wei,

Tao Hong, Ying Liu

et al.

International Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: May 7, 2024

The underlying mechanism of SENP5 influences neuronal regeneration and apoptosis in the context TBI remains largely unexplored.

Language: Английский

Citations

0
RAB17 promotes endometrial cancer progression by inhibiting TFRC-dependent ferroptosis DOI Creative Commons
Xing Zhou,

Miaomiao Nie,

Xiaoyan Xin

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(9)

Published: Sept. 6, 2024

Studies have indicated that RAB17 expression levels are associated with tumor malignancy, and is more highly expressed in endometrial cancer (EC) tissues than peritumoral tissues. However, the roles potential mechanisms of EC remain undefined. The present study confirmed facilitates progression by suppressing cellular ferroptosis-like alterations. Mechanistically, attenuated ferroptosis cells inhibiting transferrin receptor (TFRC) protein a ubiquitin proteasome-dependent manner. Because blood-deprived poor energy supply, relationship between hypoglycemia was investigated. increased incubated low-glucose medium. Moreover, medium limited cell promoted through RAB17-TFRC axis. vitro results were corroborated vivo studies clinical data. Overall, revealed promotes survival during glucose deprivation onset TFRC-dependent ferroptosis.

Language: Английский

Citations

0
Connecting the dots: Involvement of methyltransferase-like 3, N6-methyladenosine modification, and ferroptosis in the pathogenesis of intracerebral hemorrhage pathogenesis DOI

Junxiang Mao,

Quantang Zhao,

Man Guo

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 382, P. 114948 - 114948

Published: Sept. 10, 2024

Language: Английский

Citations

0
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship DOI
Jingyuan Zhang, Feng Lin, Yue Xu

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Language: Английский

Citations

0
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

Citations

0