A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients DOI Creative Commons
Hong Zeng,

Xitong Geng,

Hao Wan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10397 - 10419

Published: Dec. 1, 2024

Background: The ubiquitin-proteasome system (UPS) is vital for protein quality control and its dysregulation linked to diseases, including cancer. Targeting the UPS becoming a promising approach in cancer therapy. However, role of modulation thyroid carcinoma (THCA) remains be fully elucidated. Methods: Initially, we utilized data from Cancer Genome Atlas (TCGA) database employ weighted gene co-expression network analysis (WGCNA) with LASSO regression develop prognostic model core genes implicated THCA. Subsequently, stratified THCA training set into two distinct subtypes based on score (UPS-PMS) characteristics. Key within were then subjected functional analysis, immunotherapy evaluation, drug sensitivity studies. Results: We delineated comprising six genes, which subsequently demonstrated was capable forecasting patient prognosis. Moreover, our findings indicated substantial correlation between UPS-PMS immune microenvironmental factors, notably negative myeloid cells potential influence Th1 Th2 ratio. Especially, observed significant association high an immunosuppressive microenvironment. Then, elucidated biological distinctions among various sample subtypes, highlighting that cluster_1 subtype associated unfavorable Of note, KCNA1 identified as pivotal framework. constructed three-tiered regulatory centered KCNA1-related competing endogenous RNA (ceRNA). Furthermore, results suggested has target immunotherapeutic strategies. Concurrently, analyses expression promoted gemcitabine resistance patients, while knockdown increased gemcitabine. Conclusion: In conclusion, developed novel UPS-based THCA, key KCNA1, assessed sensitivity, revealing new therapeutic targets. Keywords: system, carcinoma, model, microenvironment,

Language: Английский

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease DOI Creative Commons
Ilenia Pellarin, Alessandra Dall’Acqua, Andrea Favero

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 12, 2025

Abstract Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as kinases able drive division. In reality, human genome contains 20 different CDKs, which can be divided in at least three sub-family with functions, mechanisms regulation, expression patterns and subcellular localization. Most these play fundamental roles normal physiology eucaryotic cells; therefore, their deregulation is associated onset and/or progression multiple disease including but not limited neoplastic neurodegenerative conditions. Here, we describe functions categorized into main functional groups they classified, highlighting most relevant pathways that functions. We then discuss potential CDKs pathologies, a particular focus on cancer, have extensively studied explored therapeutic targets. Finally, how inhibitors become standard therapies selected cancers propose novel ways investigation export targeting from cancer other chronic diseases. hope effort made collecting all available information both prominent lesser-known CDK family members will help identify develop areas research improve lives patients affected by debilitating

Language: Английский

Citations

7
Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Ubiquitin-modifying enzymes in thyroid cancer：Mechanisms and functions DOI Creative Commons
Xingmin Xiong,

BenBen Huang,

Zhe Gan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34032 - e34032

Published: July 1, 2024

Thyroid cancer is the most common malignant tumor of endocrine system, and evidence suggests that post-translational modifications (PTMs) epigenetic alterations play an important role in its development. Recently, there has been increasing linking dysregulation ubiquitinating enzymes deubiquitinases with thyroid cancer. This review aims to summarize our current understanding ubiquitination-modifying cancer, including their regulation oncogenic pathways proteins. The development progression requires further study, which will provide new insights into prevention, treatment novel agents.

Language: Английский

Citations

1
A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients DOI Creative Commons
Hong Zeng,

Xitong Geng,

Hao Wan

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10397 - 10419

Published: Dec. 1, 2024

Background: The ubiquitin-proteasome system (UPS) is vital for protein quality control and its dysregulation linked to diseases, including cancer. Targeting the UPS becoming a promising approach in cancer therapy. However, role of modulation thyroid carcinoma (THCA) remains be fully elucidated. Methods: Initially, we utilized data from Cancer Genome Atlas (TCGA) database employ weighted gene co-expression network analysis (WGCNA) with LASSO regression develop prognostic model core genes implicated THCA. Subsequently, stratified THCA training set into two distinct subtypes based on score (UPS-PMS) characteristics. Key within were then subjected functional analysis, immunotherapy evaluation, drug sensitivity studies. Results: We delineated comprising six genes, which subsequently demonstrated was capable forecasting patient prognosis. Moreover, our findings indicated substantial correlation between UPS-PMS immune microenvironmental factors, notably negative myeloid cells potential influence Th1 Th2 ratio. Especially, observed significant association high an immunosuppressive microenvironment. Then, elucidated biological distinctions among various sample subtypes, highlighting that cluster_1 subtype associated unfavorable Of note, KCNA1 identified as pivotal framework. constructed three-tiered regulatory centered KCNA1-related competing endogenous RNA (ceRNA). Furthermore, results suggested has target immunotherapeutic strategies. Concurrently, analyses expression promoted gemcitabine resistance patients, while knockdown increased gemcitabine. Conclusion: In conclusion, developed novel UPS-based THCA, key KCNA1, assessed sensitivity, revealing new therapeutic targets. Keywords: system, carcinoma, model, microenvironment,

Language: Английский

Citations

0