Identification of novel ferroptosis-related biomarkers associated with the oxidative stress pathways in ischemic cardiomyopathy DOI Creative Commons
Huilin Liu, Yuan Xu,

Yuanmei Liu

et al.

IJC Heart & Vasculature, Journal Year: 2024, Volume and Issue: 56, P. 101584 - 101584

Published: Dec. 21, 2024

Language: Английский

Mechanisms of Ferroptosis in bone disease: A new target for osteoporosis treatment DOI
Dong Wang, Jiahui Shen, Yan Wang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111598 - 111598

Published: Jan. 7, 2025

Language: Английский

Citations

2
Green tea enriched with catechins prevents particulate matter2.5 exposure-induced cardiovascular cytotoxicity via regulation of ferroptosis in BALB/c mice DOI
Jong‐Min Kim, Hyo Lim Lee, Min Ji Go

et al.

Food Science and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

1
Programmed cardiomyocyte death in myocardial infarction DOI
Hao Wu,

Qi Lan,

Yi-Xiang He

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
Targeting Ferroptosis and Ferritinophagy Improves Tooth Extraction Socket Healing in Type 2 Diabetes Mellitus Via Human Bone Marrow Mesenchymal Stem Cells Modulation DOI
Yifeng Bian, Jianfeng Li, Fan Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway DOI

Rujin Liu,

Lina Dai, Shenshan Jia

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Ferroptosis in Neurons: A Bibliometric Analysis of Research Trends, Key Contributions, and Emerging Directions DOI Creative Commons
Shanshan Sun,

Q Q Wang,

Ziyi Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Abstract Background Neurons are the fundamental structural and functional units of nervous system, serving as core cells for information transmission regulation. They closely associated with various neurological diseases. Recent studies have shown significant advancements in research on ferroptosis neurons; however, there has been a lack bibliometric analysis this field. This study aims to provide comprehensive overview knowledge structure related neurons through methods, identify current trends hotspots, predict potential future directions. Methods We conducted search publications from 2014 2024 Web Science Core Collection (WoSCC) database. Bibliometric methods were employed analyze authors, institutions, countries, journals, references using VOSviewer, CiteSpace, R package "bibliometrix". Results included 685 articles 50 China United States being leading contributors. The number year-on-year increase. primary institutions Central South University, Harbin Medical University Melbourne. Free Radical Biology Medicine is most popular journal field, while Cell highest citation count. A total 4,673 authors contributed research, David Devos Ashley I. Bush having publications, Scott J. Dixon had co-citations. Keyword revealed that molecular mechanisms its application diseases focuses Conclusion first summarizing developments neurons. outlines predicts global hotspots trends, providing valuable scholars studying ferroptosis.

Language: Английский

Citations

0
Protective effects of sevoflurane conditioning against myocardial ischemia-reperfusion injury: a review of evidence from animal and clinical studies DOI Creative Commons

Jiefu Lin,

Xia Li, Yuhui Yang

et al.

Anesthesiology and Perioperative Science, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 21, 2025

Abstract Pharmacological interventions with the inhaled anesthetic sevoflurane, widely used in cardiac surgery, have been reported to mimic cardioprotection produced by ischemic conditioning against myocardial ischemia–reperfusion injury. Beneficial effects of sevoflurane vary dose, time window and duration a variety studies involving both laboratory experiments clinical trials. However, are impaired or lost subjects diabetes settings mechanisms incompletely understood. This article summarizes major findings investigating sevoflurane-induced protection. Our aim is provide better understanding interrelated but poorly described signaling pathways. Moreover, this may facilitate development more effective therapeutic preventive strategies for ischemia-reperfusion

Language: Английский

Citations

0
Cross-Sectional Study Demonstrating Specificity of Iron Kinetics in Atrial Fibrillation DOI Open Access
Takahiro Kamihara, Shinji Kaneko, Takuya Omura

et al.

Circulation Reports, Journal Year: 2025, Volume and Issue: 7(3), P. 160 - 167

Published: Feb. 5, 2025

In the context of cardiovascular disease (CVD), iron metabolism assessment plays a pivotal role in diagnosis anemia and chronic inflammation. However, data regarding prevalence anemia, deficiency, overload among outpatients real-world clinical settings remain limited. Moreover, influence specific diseases on kinetics within CVD spectrum has not been fully elucidated. We conducted retrospective analysis 260 patients attending cardiology outpatient clinic who had undergone blood sampling for comprehensive evaluation kinetics. The these was 36.1%, but deficiency observed only 13.8% (absolute deficiency: 1.5%). Notably, stored positively correlated with free sinus rhythm, atrial fibrillation (AF). Intriguingly, this relationship followed similar pattern paroxysmal longstanding AF subgroups. multivariate regression showed that dynamics significantly explained hemoglobin levels rhythm those AF. Although inflammation may be contributing factor, exhibited distinct profile correlation between transferrin saturation iron, evident patients, abolished AF, which supports notion

Language: Английский

Citations

0
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis DOI
Lihua Sun,

Yajuan Niu,

Bo Liao

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: March 14, 2025

Language: Английский

Citations

0
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway DOI Creative Commons
Xize Wu, Xue Pan, Jian Kang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Ferulic acid (FA) has shown potential in treating atherosclerosis (AS) by improving lipid metabolism and exerting anti-hypoxic effects. This study aimed to validate the mechanism of FA AS through vitro experiments. Network analysis was employed predict mechanisms underlying therapeutic effects on AS. An foam cell model established using RAW 264.7 cells treated with ox-LDL. Cellular accumulation detected Oil Red O staining; viability assessed counting kit-8; mitochondrial morphology function were evaluated transmission electron microscopy JC-1 apoptosis levels TUNEL DAPI Fe2+ content measured Mito-FerroGreen; Western blot performed determine protein expression HIF-1α, Bax, Bcl2, GPX4, EGFR. suggested that may exert its HIF-1 signaling pathway is closely associated regulation ferroptosis apoptosis. upregulated ALOX5, BCL2, ERN1, NOS3, SLC2A1 mRNA downregulated BAX, CYCS, EGFR, FLT1, HIF1A, NFKB1, NOS2, PARP1, STAT3 mRNA. In experiments demonstrated reduces accumulation, increases viability, improves function, decreases reactive oxygen species content. Additionally, inhibited suppressing pathway, up-regulating GPX4 down-regulating HIF-1α Bax protein. agonists reversed these activating pathway. suppresses inhibiting thereby

Language: Английский

Citations

0