Dietary Rutin Ameliorates Nanoparticle Zinc Oxide-Induced Toxicity in Mice by Potentiating Antioxidant Defense Mechanisms

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1495 - 1495

Published: April 29, 2025

In animal production, nanoparticulate zinc oxide exhibits synergistic antibacterial efficacy coupled with growth-promoting effects, positioning itself as a novel antibiotic alternative enhanced biosafety profiles. However, its dose-dependent toxicity poses challenges. Objective: The experimental design sought to quantify the protective effects of dietary rutin against zinc-overload-induced damage. Methods: A zinc-overload murine model was established by giving high-dose ZnO nanoparticles (HZn, 5000 mg/kg/day) for 21 days. Mice were then fed at doses 300, 600, or 1200 mg/kg. Body weight, relative organ indexes, concentrations, serum enzyme activities, and tissue-level indicators apoptosis, autophagy, mitochondrial function, antioxidant capacity measured. Results: results showed that could not reverse HZn-induced body weight decline but improved indexes in liver kidney. It alleviated cell damage jejunum through Nrf2 activation, without inhibiting elevation. Conclusions: Rutin, especially 600 mg/kg, can partially restore hepatic function index mitigate jejunal injuries.

Language: Английский

Toxicology of Nanomaterials With a Special Focus on the Nervous System

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 27 - 64

Published: Oct. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Language: Английский