Exosomal signaling in gynecologic cancer development: The role of cancer-associated fibroblasts DOI
Mohamed J. Saadh, Omer Qutaiba B. Allela,

Radhwan Abdul Kareem

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155766 - 155766

Published: Dec. 10, 2024

Language: Английский

The tumor microenvironment's gambit: Exosomal pawns on the board of head and neck cancer DOI

Solmaz Mohamadi,

Parisa Mehrasa,

Bahareh Mehramuz

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189189 - 189189

Published: Sept. 1, 2024

Language: Английский

Citations

6
JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases DOI Creative Commons

Yimeng Dai,

Chunguo Cui,

Dan Jiao

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation JAK/STAT pathway implicated promoting or inhibiting ferroptosis, depending on context. JAK2 promotes activating STAT proteins, modulating expression key regulators like SLC7A11 GPX4, influencing iron homeostasis through pathways such as ferritinophagy hepcidin regulation. STAT1 activation primarily enhances suppression cystine-glutamate antiporter (System Xc-), leading to glutathione depletion contributing conditions Sjogren's syndrome age-related macular degeneration. In contrast, STAT3 plays protective upregulating which inhibits survival, particularly cancers hepatocellular carcinoma, prostate renal carcinoma. also discusses STAT6's involvement diseases asthma lung injury regulating antioxidant defenses. Furthermore, review explores potential therapeutic strategies targeting manipulate for disease treatment. cancer therapy, this can enhance effectiveness inducers, offering promising avenues overcome drug resistance. Additionally, interplay immune responses, oxidative stress, metabolism underscores significance progression intervention. By exploring these mechanisms, provides insights into development novel treatments modulation, with implications inflammatory neurodegenerative conditions.

Language: Английский

Citations

0
Battlegrounds of treatment resistance: decoding the tumor microenvironment DOI
Mobina Bayat, Javid Sadri Nahand

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Circular RNAs: driving forces behind chemoresistance and immune evasion in bladder cancer DOI

Mohamed J. Saadh,

Wael K.A. Hussein,

Ali Fawzi Al-Hussainy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
To be or not to be: navigating the influence of MicroRNAs on cervical cancer cell death DOI Creative Commons
Mohammad Taghizadieh,

Mina Kalantari,

Roksana Bakhshali

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 18, 2025

With all diagnostic and therapeutic advances, such as surgery, radiation- chemo-therapy, cervical cancer (CC) is still ranked fourth among the most frequent cancers in women globally. New biomarkers targets are warranted to be discovered for early detection, treatment, prognosis of CC. As component non-coding RNA's family, microRNAs (miRNAs) participate several cellular functions cell proliferation, gene expression, many signaling cascades, apoptosis, angiogenesis, etc. MiRNAs can suppress or induce programmed death (PCD) pathways by altering their regulatory genes. Besides, abnormal expression miRNAs weakens promotes various associated with PCD, resulting development human diseases For that reason, understanding effects exert on modes tumor evaluating potential serve induction reappearance chemotherapy. The current study aims define effect autophagy, pyroptosis, ferroptosis, anoikis investigate possible therapy. Manipulating PCD could considered a primary strategy cancer.

Language: Английский

Citations

0
Bile’s Hidden Weapon: Modulating the Microbiome and Tumor Microenvironment DOI

Mohamed J. Saadh,

Hanan Hassan Ahmed,

Ali Fawzi Al-Hussainy

et al.

Current Microbiology, Journal Year: 2024, Volume and Issue: 82(1)

Published: Nov. 30, 2024

Language: Английский

Citations

1
Exosomal microRNAs in cancer metastasis: A bridge between Tumor micro and macroenvironment DOI
Mohamed J. Saadh,

Amirmohammad Khalifehsoltani,

Abbas Hameed Abdul Hussein

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155666 - 155666

Published: Oct. 25, 2024

Language: Английский

Citations

0
Exosomal signaling in gynecologic cancer development: The role of cancer-associated fibroblasts DOI
Mohamed J. Saadh, Omer Qutaiba B. Allela,

Radhwan Abdul Kareem

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155766 - 155766

Published: Dec. 10, 2024

Language: Английский

Citations

0