Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective DOI Creative Commons
Jing Guo, Yi Cao, Qingyuan Wu

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2669 - 2686

Published: Nov. 1, 2024

The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. steady-state regular changes microenvironment around wound provide good conditions for healing achieve a dynamic complex process healing.The pH value ionic environment composed variety ions important factors affecting microenvironment, there direct or indirect connections between them. Abnormalities pH, ion concentrations, channels skin tissue may be one reasons difficulty healing. Currently, different wound-dressing applications have been developed based on efficacy ions. Here, effect wounds, concentrations calcium (Ca

Language: Английский

Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment DOI Creative Commons

Zui Tian,

Xudong Wang,

Shuai Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1509 - 1528

Published: Feb. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Language: Английский

Citations

0
WO3‐x@Ferrocene‐Folic Acid Composites Induce Cancer Cell Death and Activate Immunity via PTT/CDT DOI Open Access
Qi Wu,

Mingyang Liu,

Hui Zhang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

At present, tumor immune escape is a major problem in the treatment of tumors. The complex network microenvironments significantly impairs efficacy immunotherapy. This paper reports preparation and immunoantitumor activity novel multifunctional defect tungsten trioxide@ferrocene-folic acid composite (WO3-x@Fe-FA) with high Fenton reaction rate. Ferrocene modified on surface defective trioxide by covalent coupling method for first time, rate increased 10 times. WO3-x@Fe-FA induces immunogenic cell death (ICD) through powerful synergistic anti-tumor effect PTT/CDT decomposes H2O2 to produce oxygen reaction, thus down-regulating expression checkpoint PD-L1 induced hypoxia. In vitro vivo experiments proved that reverses immunosuppressive microenvironment, transforms "cold tumor" into "hot tumor", activates system. show has excellent activity, it expected be candidate drug therapy.

Language: Английский

Citations

0
Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers DOI
Ahmad Besaratinia

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Despite the popularity of electronic cigarettes (e-cigs) among adolescent and youth never-smokers adult smokers seeking a less harmful substitute for tobacco cigarettes, long-term health impact vaping is largely unknown. Biochemical, molecular, toxicological analyses biospecimens from e-cig users as well assays in relevant vitro models silico studies can identify chemical constituents emissions that may contribute to disease-causing potential vaping. E-cig aerosol contains wide range toxic carcinogenic compounds, which metals are particular concern. This due known or suspected role various pathogenesis numerous diseases. Many metalloids (herein referred "metals") have been detected liquid (e-liquid) and/or cells, tissues, biofluids, other specimens users. Metals contaminate ingredients e-liquid corrode internal components device. also be directly aerosolized surface heating element parts Inhalation metal habitual vapers nonusers through secondary exposure increase body burden chemicals. review summarizes state research on e-cig-derived their contributions estimated risks Highlighting composition aerosol, it focuses contents inhaled associated with this exposure. Emphasis placed adolescents who vulnerable populations bear disproportionate risk harm products. The gaps knowledge, methodological challenges, opportunities ahead discussed. importance translating findings into actionable information used regulation manufacturing products underscored.

Language: Английский

Citations

0
Serum potassium level is associated with serum neurofilament light chain in American adult population: a cross-sectional analysis of the 2013–2014 National Health and Nutrition Examination Survey DOI Creative Commons
Yao Kong, Yanghao Tai, Bin Chen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 18, 2025

Serum neurofilament light chain (sNfL) is one of the most sensitive diagnostic biomarkers for a variety neurodegenerative pathologies. Potassium, an essential electrolyte, plays critical role in maintaining neuronal health and proper functioning central nervous system (CNS). The aim our research was to investigate association between serum potassium level sNfL levels. Based on National Health Nutrition Examination Survey (NHANES) database, we analyzed data from 2013 2014 NHANES. concentrations were measured via ion-selective electrode (ISE) technology. levels using immunoassay developed by Siemens Healthineers. Our researcher American persons multivariate logistic regression analysis smoothed curve fitting. consistency these results examined various population subgroups. A total 1,670 participants involved research, including 872 women (50.5%) 798 men (49.5%). median concentration 4.0 mmol/L 12.3 pg/ml. After adjusting potential confounders full model, individuals with higher had (Q3 vs. Q1, β = 2.86, 95% CI: 0.33-5.39, P 0.027). There non-linear positive dose-response (P non-linearity 0.028). stratified analysis, relationship stronger low- middle-income group, non-drinking non-physical activity participants, hypertension diabetes. In cohort adults, greater linked sNfL. However, causality still needs be further verified.

Language: Английский

Citations

0
GSH-responsive targeted copper-based nanoparticle improve ovarian cancer treatment via induction of apoptosis-ferroptosis-cuproptosis DOI Creative Commons
Lan Ma,

Sihong Guo,

Xinlei Yang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113944 - 113944

Published: April 1, 2025

Language: Английский

Citations

0
HO-1-Mediated Ferroptosis Regulates Retinal Neovascularization via the COX2/VEGFA Axis DOI
Haixiang Zhou, Bingyan Li,

Zicong Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 226, P. 84 - 95

Published: Nov. 12, 2024

Language: Английский

Citations

2
Nanodrug‐Engineered Exosomes Achieve a Jointly Dual‐Pathway Inhibition on Cuproptosis DOI Creative Commons
Hanxiao Sun,

Yang Zou,

Zhengtai Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Cuproptosis, caused by an intracellular overload of copper (Cu) ions and overexpression ferredoxin 1 (FDX1), is identified for its regulatory role in the skin wound healing process. This study verifies presence cuproptosis beds reactive oxygen species‐induced cells model. To address two pathways leading to cell cuproptosis, a nanodrug‐engineered exosomes proposed. A Cu‐chelator (Clioquinol, CQ) polydopamine (PDA)‐modified stem exosome loaded with siRNA‐FDX1, named EXO siFDX1‐PDA@CQ , designed efficiently inhibit pathways. The functionalized are into injectable hydrogel applied treat diabetic wounds mice acute pigs. local controlled release ensures retention therapeutic agent at beds, effectively promoting healing. strategy engineered functional nanoparticles (NPs) proposed this offers efficient scalable new approach regulating cuproptosis.

Language: Английский

Citations

1
Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective DOI Creative Commons
Jing Guo, Yi Cao, Qingyuan Wu

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2669 - 2686

Published: Nov. 1, 2024

The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. steady-state regular changes microenvironment around wound provide good conditions for healing achieve a dynamic complex process healing.The pH value ionic environment composed variety ions important factors affecting microenvironment, there direct or indirect connections between them. Abnormalities pH, ion concentrations, channels skin tissue may be one reasons difficulty healing. Currently, different wound-dressing applications have been developed based on efficacy ions. Here, effect wounds, concentrations calcium (Ca

Language: Английский

Citations

0