International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114661 - 114661
Published: April 22, 2025
Language: Английский
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113974 - 113974
Published: Jan. 1, 2025
Language: Английский
Citations
0
Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Intervertebral disc degeneration (IVDD) is a major cause of low back pain. An increasing number studies have demonstrated that circRNAs regulate the progression IVDD. However, specific role circ_0000389 in IVDD not clear. In this study, selected by bioinformatics analysis GSE67566 dataset. RT-qPCR performed to detect expressions circ_0000389, miR-346 and KLF7 nucleus pulposus (NP) tissues. The proliferative capacity cells (NPCs) examined via CCK-8 assay. Western blot extracellular matrix (ECM) catabolism NPCs. Dual-luciferase reporter gene assays RNA immunoprecipitation (RIP) confirm interaction with KLF7. expression significantly downregulated degenerating NP Functionally, inhibits ECM catabolism. Mechanistically, we identify as downstream target genes miR-346, respectively. overexpression reverses effect on NPCs, indicating alleviates regulating miR-346/KLF7 axis. This study may provide new therapeutic for treatment
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 10, 2025
Lipid metabolism encompasses the processes of digestion, absorption, synthesis, and degradation fats within biological systems, playing a crucial role in sustaining normal physiological functions. Disorders lipid metabolism, characterized by abnormal blood levels dysregulated fatty acid have emerged as significant contributors to intervertebral disk degeneration (IDD). The pathogenesis IDD is multifaceted, encompassing genetic predispositions, nutritional metabolic factors, mechanical stressors, trauma, inflammatory responses, which collectively facilitate progression IDD. Although precise mechanisms underlying remain incompletely elucidated, there substantial consensus regarding close association between disorders its development. Intervertebral disks are essential for maintaining spinal alignment. Their primary functions encompass shock preservation curvature, facilitation movement, provision stability. elasticity thickness these effectively absorb daily impacts, safeguard spine, uphold natural curvature flexibility, while also creating space nerve roots prevent compression ensure transmission signals. Research indicates that such disturbances may compromise functionality cartilaginous endplates (CEP) nucleus pulposus (NP), thereby facilitating IDD’s onset progression. CEP integral internal material exchange absorption mitigating NP herniation under load conditions. As central component disks, height providing shock-absorbing capabilities; thus, damage critical structures accelerates Furthermore, contribute through including activation endoplasmic reticulum stress pathways, enhancement oxidative levels, induction cellular pyroptosis alongside inhibition autophagy processes—coupled with promotion inflammation-induced fibrosis fibroblast proliferation leading calcification disks. This review delineates intricate interplay IDD; it anticipated advancing our understanding this will pave way more effective preventive measures therapeutic strategies against future research.
Language: Английский
Citations
0
Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: March 19, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114661 - 114661
Published: April 22, 2025
Language: Английский
Citations
0