Polymer Nanoparticles Advancements for Gynecological Cancers DOI Creative Commons

Xiaorui Lin,

Zihan Li,

Yibao Huang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6721 - 6742

Published: May 1, 2025

Gynecological cancers represent one of the leading causes death in women and pose a critical global health challenge. While surgery chemotherapy remain first-line therapies for gynecological cancers, persistently high morbidity mortality rates have driven urgent exploration novel theranostic strategies. In recent years, polymer nanoparticles (PNPs) gained increasing attention diagnosis treatment cancer due to their superior targeting ability delivery efficiency. This review provides an overview PNPs role tumor treatment, with strategic focus on utility cancers. It covers drug delivery, imaging, combination therapy, integration summarizes composition, principles characteristics diverse polymers cargoes. Furthermore, this work highlights innovative applications management, spanning chemotherapy, immunotherapy, PARPi phototherapy other therapies. Despite promising preclinical advancements PNPs, formidable challenges persist clinical translation. serves as comprehensive resource researchers clinicians aiming optimize theranostics well accelerate development translation PNPs.

Language: Английский

Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy DOI Creative Commons
Yibo He, Qianran Hong, Shiliang Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Gastric cancer (GC) remains a significant global health concern due to its poor prognosis and limited therapeutic options, particularly in advanced stages. Tumor microenvironment (TME), tumor-associated macrophages (TAMs), plays key role tumor progression, immune evasion, therapy resistance. TAMs exhibit plasticity, shifting between pro-inflammatory M1 immunosuppressive M2 phenotypes, with the latter predominating GC contributing outcomes. Recent advancements focus on targeting TAMs, including inhibiting polarization, reprogramming combining TAM-targeted approaches checkpoint inhibitors. Innovations nanotechnology, metabolic reprogramming, pathways such as interleukin-6 C-C motif ligand 2/C-C chemokine receptor 2 further enhance these strategies. However, challenges remain, spatial functional heterogeneity of within TME need for selective avoid disrupting homeostasis. Ongoing research TAM origins, functions, interactions is crucial developing precise effective therapies. These advances hold promise not only improving outcomes but also addressing other cancers similarly complex microenvironments.

Language: Английский

Citations

4
Insights into the Molecular Mechanisms and Nanoparticle-Based Therapies for Gastric Cancer: A review DOI Creative Commons

Smarika Chauhan,

Eswar Marcharla,

Sneha Hariharan

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 104238 - 104238

Published: Feb. 1, 2025

Language: Английский

Citations

1
Nanomaterials in gastric cancer: pioneering precision medicine for diagnosis, therapy, and prevention DOI

Tiantian Liu,

Ying-Qiu Gu, Zaili Yang

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

Citations

1
Silencing circ_0043256 inhibited CoCl2-induced proliferation, migration, and aerobic glycolysis in gastric cancer cells DOI Creative Commons
Wen‐Ting Ou,

Rong-Jian Tan,

Jiawei Zhai

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

Citations

0
Ultrasound Assisted Green Synthesis of Lignosulfonate-Gold Nanocomposite (LS-Au NPs): The Study of Its Application in the Suzuki–Miyaura Coupling Reactions and Its Application for the Treatment of Gastric Cancer DOI
Ran Wang,

Ni Wei,

Shuhua Fang

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

0
Nanomaterials for targeted drug delivery for immunotherapy of digestive tract tumors DOI Creative Commons
Mingzhu Li,

Ningxin Li,

Haozhe Piao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The incidence and mortality rates of digestive tract tumors, especially gastric colorectal cancers, are high worldwide. Owing to their unique advantages, such as efficient drug loading, safety, targeting properties, nanoparticles (NPs) have demonstrated great potential in the treatment gastrointestinal tumors. However, practical application is limited by several factors, costs, few clinical trials, long approval periods. In this review, we summarize three types immunotherapeutic nanomaterial drugs for tumors: organic, inorganic, hybrid nanomaterials. This article also discusses current status research development field advantages each type material provide theoretical references developing new advancing research.

Language: Английский

Citations

0
Cutting-edge nanotechnology: unveiling the role of zinc oxide nanoparticles in combating deadly gastrointestinal tumors DOI Creative Commons

Yonggang Guo,

Mohammadamin Morshedi

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 20, 2025

Zinc oxide nanoparticles (ZnO-NPs) have gained significant attention in cancer therapy due to their unique physical and chemical properties, particularly treating gastrointestinal (GI) cancers such as gastric, colorectal, hepatocellular carcinoma. These generate reactive oxygen species (ROS) upon entering cells, causing oxidative stress that leads cellular damage, DNA fragmentation, apoptosis. ZnO-NPs affect the expression of key proteins involved apoptosis, including p53, Bax, Bcl-2, which regulate cell cycle arrest programmed death. Additionally, can reduce mitochondrial membrane potential, further enhancing apoptosis cells. Furthermore, inhibit proliferation by interfering with progression. They levels cyclins cyclin-dependent kinases (CDKs), leading arrest. also exhibit anti-metastatic properties inhibiting migration invasion cells through modulation signaling pathways adhesion cytoskeletal dynamics. The efficacy overcoming chemotherapy resistance has been demonstrated ability IC50 values chemotherapeutic agents, making more susceptible drug-induced In this review, we summarize mechanisms exert anticancer effects GI cancers, focusing on regulation, metastasis inhibition, while highlighting current limitations translating these findings into effective clinical treatments.

Language: Английский

Citations

0
Polymer Nanoparticles Advancements for Gynecological Cancers DOI Creative Commons

Xiaorui Lin,

Zihan Li,

Yibao Huang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6721 - 6742

Published: May 1, 2025

Gynecological cancers represent one of the leading causes death in women and pose a critical global health challenge. While surgery chemotherapy remain first-line therapies for gynecological cancers, persistently high morbidity mortality rates have driven urgent exploration novel theranostic strategies. In recent years, polymer nanoparticles (PNPs) gained increasing attention diagnosis treatment cancer due to their superior targeting ability delivery efficiency. This review provides an overview PNPs role tumor treatment, with strategic focus on utility cancers. It covers drug delivery, imaging, combination therapy, integration summarizes composition, principles characteristics diverse polymers cargoes. Furthermore, this work highlights innovative applications management, spanning chemotherapy, immunotherapy, PARPi phototherapy other therapies. Despite promising preclinical advancements PNPs, formidable challenges persist clinical translation. serves as comprehensive resource researchers clinicians aiming optimize theranostics well accelerate development translation PNPs.

Language: Английский

Citations

0