Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2306 - 2306

Published: March 28, 2025

Acute Kidney Injury (AKI) is a severe clinical condition featured by rapid decrease in kidney function short period of time. AKI, which often secondary to sepsis, ischemia-reperfusion and drug toxicity, associated high morbidity mortality. Moreover, it contributes the development chronic disease (CKD), due maladaptive or incomplete repair mechanisms, resulting renal fibrosis. Small non-coding RNA has recently emerged as novel biomarker for early detection treatment AKI. In particular, microRNAs (miRNAs) are molecules 21-25 nucleotides regulating expression protein-coding genes through sequence-specific recognition. Due their stability biological fluids, such urine plasma, they can be reliably analyzed quantified, this reason considered potential diagnostic therapeutic biomarkers. Specifically, miRNAs have been demonstrated predict AKI before increase creatinine levels, thus improving management syndrome. review, we provide comprehensive overview role urinary plasma

Language: Английский

The Role of Viral Infections in Acute Kidney Injury and Mesenchymal Stem Cell-Based Therapy

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Extracellular Vesicles in Renal Inflammatory Diseases: Revealing Mechanisms of Extracellular Vesicle-Mediated Macrophage Regulation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3646 - 3646

Published: April 12, 2025

Renal inflammatory diseases are a group of severe conditions marked by significant morbidity and mortality. Extracellular vesicles (EVs), as facilitators intercellular communication, have been recognized pivotal regulators renal diseases, significantly contributing to these modulating immune responses among other mechanisms. This review highlights the intricate mechanisms through which EVs modulate macrophage-kidney cell interactions regulating macrophages, principal cells within milieu. regulation subsequently influences pathophysiology such acute kidney injury chronic disease. Furthermore, understanding offers novel opportunities alleviate consequences associated with diseases. In addition, we summarize therapeutic landscape based on EV-mediated macrophage regulatory mechanisms, highlighting potential biomarkers targets well challenges limitations translating therapies into clinical practice.

Language: Английский