Laser Physics Letters,
Journal Year:
2025,
Volume and Issue:
22(5), P. 055601 - 055601
Published: April 28, 2025
Abstract
Breast
cancer
is
the
most
common
type
of
in
women
worldwide.
Several
factors,
such
as
reactive
oxygen
species
(ROS)
are
involved
pathophysiology
cancer.
At
low
levels,
ROS
could
act
signaling
molecules,
but
at
high
cause
oxidative
damages
and
programmed
cell
death.
Photobiomodulation
(PBM)
comes
from
interaction
photoacceptors
with
photons
emitted
by
low-power
lasers
light-emitting
diodes
(LEDs),
which
leaves
to
releasing
ROS.
PBM
induce
apoptosis
increasing
level
cells.
However,
there
few
data
on
effects
breast
cells,
blue
light
simultaneous
red
necrosis
Thus,
this
study
aimed
evaluate
ROS,
levels
human
cultures
after
exposure
laser
LED.
MCF-7
MDA-MB-231
cells
were
irradiated
a
(69
J
cm
−2
,
0.77
W
)
LED
(482
5.35
),
alone
or
combination,
apoptosis,
evaluated
flow
cytometry.
The
results
showed
that
therapeutic
alters
death
rates
This
indicates
redox
status
process
be
considered
for
development
alternative
treat
control
Alzheimer s Research & Therapy,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: April 5, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disease.
Amyloid
β-protein
(Aβ)
one
of
the
key
pathological
features
AD,
which
cytotoxic
and
can
damage
neurons,
thereby
causing
cognitive
dysfunction.
Photobiomodulation
(PBM)
non-invasive
physical
therapy
that
induces
changes
in
intrinsic
mechanisms
cells
tissues
through
low-power
light
exposure.
Although
PBM
has
been
employed
treatment
effect
precise
mechanism
on
AD-induced
neurological
are
still
unclear.
In
vivo
experiments,
(808
nm,
20
mW/cm2)
was
used
to
continuously
interfere
with
APP/PS1
mice
for
6
weeks,
then
their
function
AD
were
evaluated.
vitro
lipopolysaccharide
(LPS)
induce
microglia
model
inflammation,
polarization
status
phagocytic
Aβ
ability
Hexokinase
2
(HK2)
inhibitor
3-bromopyruvate
(3BP)
study
mitochondrial
energy
metabolism
microglia.
further
ameliorates
impairment
by
alleviating
neuroinflammation
neuronal
apoptosis,
attenuating
nerve
damage.
addition,
also
reduce
promoting
microglial
anti-inflammatory
phenotypic
polarization;
Promotes
clearance
enhancing
engulf
Aβ.
Among
them,
regulates
inhibits
may
be
related
its
regulation
metabolism,
promotion
oxidative
phosphorylation,
inhibition
glycolysis.
neuroinflammatory
response
repairing
Aβ-induced
Mitochondrial
plays
an
important
role
improving
injury
mice.
This
provides
theoretical
support
subsequent
application
AD.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(8), P. 4161 - 4161
Published: April 10, 2025
Fibromyalgia
syndrome
is
a
chronic
pain
condition
involving
altered
nociceptive
processing,
which
requires
multidisciplinary
management.
Photobiomodulation
therapy
(PBMT)
has
recently
emerged
as
promising
non-pharmacological
approach,
but
its
clinical
effectiveness
and
optimal
application
methods
remain
unclear.
This
systematic
review
evaluated
the
efficacy
of
PBMT
in
managing
symptoms,
including
pain,
physical
function,
sleep
quality,
overall
well-being,
while
comparing
localized
whole-body
delivery.
A
was
conducted
accordance
with
PRISMA
guidelines
previously
registered
on
PROSPERO
(CRD42024626368).
Literature
searches
were
performed
across
MEDLINE
((PubMed)),
PEDro,
SPORTDiscus,
Scopus,
Elsevier
(ScienceDirect),
Web
Science
(WOS),
identifying
17
eligible
studies
(n
=
857
participants).
applied
via
low-level
laser,
infrared,
or
LED-based
devices,
delivered
either
locally
to
whole
body.
The
methodological
quality
assessed
using
PEDro
scale,
risk
bias
RoB
2.0
tool.
showed
significant
benefits,
reduced
intensity,
improved
decreased
fatigue,
enhanced
life.
Whole-body
greater
more
sustained
effects
than
applications,
likely
due
systemic
modulation
pathways
autonomic
regulation.
Improvements
also
observed
terms
psychological
kinesiophobia.
In
conclusion,
appears
be
an
effective
therapeutic
option
for
syndrome,
applications
offering
superior
benefits.
However,
variability
treatment
parameters
study
methodologies
underscores
need
standardized
protocols
high-quality
trials
support
integration
into
management
strategies.
Laser Physics Letters,
Journal Year:
2025,
Volume and Issue:
22(5), P. 055601 - 055601
Published: April 28, 2025
Abstract
Breast
cancer
is
the
most
common
type
of
in
women
worldwide.
Several
factors,
such
as
reactive
oxygen
species
(ROS)
are
involved
pathophysiology
cancer.
At
low
levels,
ROS
could
act
signaling
molecules,
but
at
high
cause
oxidative
damages
and
programmed
cell
death.
Photobiomodulation
(PBM)
comes
from
interaction
photoacceptors
with
photons
emitted
by
low-power
lasers
light-emitting
diodes
(LEDs),
which
leaves
to
releasing
ROS.
PBM
induce
apoptosis
increasing
level
cells.
However,
there
few
data
on
effects
breast
cells,
blue
light
simultaneous
red
necrosis
Thus,
this
study
aimed
evaluate
ROS,
levels
human
cultures
after
exposure
laser
LED.
MCF-7
MDA-MB-231
cells
were
irradiated
a
(69
J
cm
−2
,
0.77
W
)
LED
(482
5.35
),
alone
or
combination,
apoptosis,
evaluated
flow
cytometry.
The
results
showed
that
therapeutic
alters
death
rates
This
indicates
redox
status
process
be
considered
for
development
alternative
treat
control
