Дискуссионные аспекты суицидологии: связь нейровоспаления с суицидальным поведением у психически здоровых людей. Сообщение II DOI Open Access
В.А. Козлов, А.В. Голенков, П.Б. Зотов

et al.

Суицидология, Journal Year: 2024, Volume and Issue: 15(02(55))

Published: Aug. 25, 2024

Патофизиология формирования суицидального поведения рассмотрена на примерах связи нейровоспаления с его проявлениями (суицидальными мыслями, суицидальными попытками и завершенными суицидами) у лиц такими психическими расстройствами, как: депрессивное расстройство (большое, перипартальная депрессия), нейрогенная (нервная) анорексия, шизофрения, а также суицидами (суицидальным поведением), связанными инфекционными заболеваниями (T.gondii, .В результате анализа большого массива

Language: Русский

Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder DOI

Cong-Ya Chen,

Yufei Wang, Lan Lei

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122815 - 122815

Published: June 11, 2024

Language: Английский

Citations

20
Regulation of the microglial polarization for alleviating neuroinflammation in the pathogenesis and therapeutics of major depressive disorder DOI
Yufei Wang,

Cong-Ya Chen,

Lan Lei

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123373 - 123373

Published: Jan. 4, 2025

Language: Английский

Citations

2
The pathogenesis of depression: roles of connexin 43-based gap junctions and inflammation DOI
Hong Jiang, Meng Zhang,

Xin-Mu Li

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 989, P. 177260 - 177260

Published: Jan. 9, 2025

Language: Английский

Citations

2
Ginsenoside Rg1: A natural triterpenoid glycoside with promising anti-depressive properties DOI
Yating Wang, Jun-Jie Jiang, Yi Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105940 - 105940

Published: Jan. 1, 2025

Language: Английский

Citations

2
Novel insight into astrocyte-mediated gliotransmission modulates the synaptic plasticity in major depressive disorder DOI
Lan Lei, Yufei Wang,

Cong-Ya Chen

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122988 - 122988

Published: Aug. 15, 2024

Language: Английский

Citations

10
Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder DOI
Yi Zhang

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105808 - 105808

Published: July 22, 2024

Language: Английский

Citations

7
Efficacy of ginsenoside Rg1 on rodent models of depression: A systematic review and meta-analysis DOI
Yating Wang, Xiaole Wang, Lei Lan

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Language: Английский

Citations

5
Identification of mitophagy-related genes and analysis of immune infiltration in the astrocytes based on machine learning in the pathogenesis of major depressive disorder DOI
Lan Lei,

Cong-Ya Chen,

Yufei Wang

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4
MicroRNA-specific targets for neuronal plasticity, neurotransmitters, neurotrophic factors, and gut microbes in the pathogenesis and therapeutics of depression DOI

Cong-Ya Chen,

Yufei Wang, Lan Lei

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111186 - 111186

Published: Nov. 7, 2024

Language: Английский

Citations

4
Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models DOI Creative Commons

Hu Yue,

Yaoxue Gan,

Lei Jia

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238

Published: Feb. 24, 2025

Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.

Language: Английский

Citations

0