Logistic regression model for predicting risk factors and contribution of cerebral microbleeds using renal function indicators DOI Creative Commons
Xuhui Liu, Zhengwei Pan, Yilan Li

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

Background The brain and kidneys share similar low-resistance microvascular structures, receiving blood at consistently high flow rates thus, are vulnerable to pressure fluctuations. This study investigates the causative factors of cerebral microbleeds (CMBs), aiming quantify contribution each risk factor by constructing a multivariate model via stepwise regression. Methods A total 164 hospitalized patients were enrolled from January 2022 March 2023 in this study, employing magnetic susceptibility-weighted imaging (SWI) assess presence CMBs. CMBs was determined SWI, history, renal function related analyzed. Results Out participants safety analysis, 36 (21.96%) exhibited 128 (78.04%) did not exhibit CMBs, median age 66 years (range: 49–86 years). Multivariate logistic regression identified hypertension (OR = 13.95%, 95% CI: 4.52, 50.07%), urea nitrogen (BUN) 1.57, 1.06–2.40), cystatin C (CyC) 4.90, 1.20–22.16), urinary β-2 microglobulin, 2.11, 1.45–3.49) as significant for marginal R -square ( RM2 ) 0.25. Among all determinants, (47.81%) had highest weight, followed UN (11.42%). Quasi-curves plotted using bootstrap method (999 times) showed good agreement between predictive actual observations. Conclusion Hypertension, BUN, CyC morbidity, controlling above indicators within reasonable range will help reduce incidence

Language: Английский

The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies DOI Creative Commons
Xiaowen Han,

Jiayi Zhang,

Weidong Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Immunotherapy has emerged as a preeminent force in the domain of cancer therapeutics and achieved remarkable breakthroughs. Nevertheless, high resistance become most substantial impediment restricting its clinical efficacy. Beta-2 microglobulin (B2M), light chain major histocompatibility complex (MHC) class I, plays an indispensable part by presenting tumor antigens to cytotoxic T lymphocytes (CTLs) for exerting anti-tumor effects. Accumulating evidence indicates that B2M mutation/defect is one key mechanisms underlying immunotherapy resistance. Therefore, elucidating role played devising effective strategies battle against are pressing issues. This review will systematically expound upon them, aiming provide insight into potential promising target anticancer immune response.

Language: Английский

Citations

2
Immunosenescence and Inflammaging: Mechanisms and Role in Diseases DOI
Amir Ajoolabady, Domenico Praticò, Daolin Tang

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102540 - 102540

Published: Oct. 10, 2024

Language: Английский

Citations

11
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review DOI
Jian Li, Weimin Zhao, Yitong Wang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 15, 2025

Language: Английский

Citations

0
Evaluation of suitable reference genes for gene expression studies in the developing mouse cortex using RT-qPCR DOI Creative Commons

Ananya Uppalapati,

Timothy C. Wang, Lena H. Nguyen

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 18, 2025

Real-time quantitative PCR (RT-qPCR) is a widely used method to investigate gene expression in neuroscience studies. Accurate relative quantification of RT-qPCR requires the selection reference genes that are stably expressed across experimental conditions and tissues interest. While often performed changes during neurodevelopment, few studies have examined stability commonly developing mouse cortex. Here, we evaluated five housekeeping genes, Actb, Gapdh, B2m, Rpl13a, Hprt, cortical tissue from mice at embryonic day 15 postnatal 0 identify optimal with stable late corticogenesis. The was assessed using computational algorithms: BestKeeper, geNorm, NormFinder, DeltaCt, RefFinder. Our results showed or combination B2m/Gapdh B2m/Hprt, were most pairs. In contrast, Actb Rpl13a least expressed. This study identifies Hprt as suitable for RT-qPCR-based development spanning period 0.

Language: Английский

Citations

0
Association and predictive value analysis of β2-microglobulin and the severity of white matter hyperintensities DOI
Wang Fei, Tingting Liu, Jun He

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Objective: To investigate the association between serum β2-microglobulin (β2M) levels and severity of White Matter Hyperintensities (WMHs) in patients with Cerebral Small Vessel Disease (CSVD), addition to evaluate its predictive value for WMHs severity. Methods: We consecutively enrolled CSVD demonstrating on MRI from Neurology Department at Second People's Hospital Hefei City December 2021 April 2024. Patient characteristics including demographic,baseline clinical, laboratory data, β2M brain features were collected. The periventricular white matter hyperintensities (PWMHs) deep (DWMHs) was assessed using Fazekas scale. Based sum scores these two regions, classified into a none or mild overall group (Fazekas score 0–2) moderate severe 3–6). Patients predominant (pred-PWMHs) subgroup (pred-DWMHs) based difference ≥ 1 point regions. Each further divided 1) groups 2–3). Independent risk factors associated WMHs, PWMHs DWMHs analyzed univariate multivariate logistic regression. evaluated receiver operating characteristic (ROC) curves. Results: A total 346 study, 183 163 WMHs. Univariate analysis revealed that age (P < 0.001), hypertension fibrinogen = 0.019), Hcyt(P 0.005), CysC Total cholesterol 0.025), LDL-C(P 0.012), eGFR 0.001) Multivariate regression identified (OR:1.050, 95%CI:1.025–1.075, P 0.001༉, (OR:2.007, 95%CI:1.202–3.349, 0.008) (OR:1.635, 95%CI:1.154–2.317, 0.006) as independent ROC curve demonstrated cut off 2.295 significantly (AUC 0.673, P 0.001).In analysis, also an factor pred-PWMHs (OR:3.134, 95%CI: 1.012–9.698, 0.048),while no observed pred-DWMHs. Conclusion: Serum are pred-PWMHs,but not Furthermore, exhibit

Language: Английский

Citations

0
Logistic regression model for predicting risk factors and contribution of cerebral microbleeds using renal function indicators DOI Creative Commons
Xuhui Liu, Zhengwei Pan, Yilan Li

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

Background The brain and kidneys share similar low-resistance microvascular structures, receiving blood at consistently high flow rates thus, are vulnerable to pressure fluctuations. This study investigates the causative factors of cerebral microbleeds (CMBs), aiming quantify contribution each risk factor by constructing a multivariate model via stepwise regression. Methods A total 164 hospitalized patients were enrolled from January 2022 March 2023 in this study, employing magnetic susceptibility-weighted imaging (SWI) assess presence CMBs. CMBs was determined SWI, history, renal function related analyzed. Results Out participants safety analysis, 36 (21.96%) exhibited 128 (78.04%) did not exhibit CMBs, median age 66 years (range: 49–86 years). Multivariate logistic regression identified hypertension (OR = 13.95%, 95% CI: 4.52, 50.07%), urea nitrogen (BUN) 1.57, 1.06–2.40), cystatin C (CyC) 4.90, 1.20–22.16), urinary β-2 microglobulin, 2.11, 1.45–3.49) as significant for marginal R -square ( RM2 ) 0.25. Among all determinants, (47.81%) had highest weight, followed UN (11.42%). Quasi-curves plotted using bootstrap method (999 times) showed good agreement between predictive actual observations. Conclusion Hypertension, BUN, CyC morbidity, controlling above indicators within reasonable range will help reduce incidence

Language: Английский

Citations

1