Reviewing the consequences of genetic purging on the success of rescue programs

Conservation Genetics, Journal Year: 2021, Volume and Issue: 23(1), P. 1 - 17

Published: Oct. 19, 2021

Abstract Genetic rescue is increasingly considered a promising and underused conservation strategy to reduce inbreeding depression restore genetic diversity in endangered populations, but the empirical evidence supporting its application limited few generations. Here we discuss on light of theory role arising from partially recessive deleterious mutations purging as main determinants medium long-term success programs. This depends two predictions: (1) The load hidden populations with long stable demography increases effective population size; (2) After shrinks, tends remove (partially) alleles, process that slower more efficient for large than small ones. We also carry out computer simulations investigate impact term For some scenarios, it found hybrid vigor followed by will lead sustained successful rescue. However, there may be specific situations where recipient so cannot purge introduced migrants, which would increased fitness extinction risk term. In such cases, expected higher if migrants came non-purged high load, particularly after accumulation stochastic effects ascribed repeated occasional migration events. Therefore, under mutation model considered, conclude additional caution should taken Unless harbors distinctive singularity whose concern, restoration continuous gene flow whenever feasible, reduces compared can allow recolonization

Language: Английский

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Coral Reef Population Genomics in an Age of Global Change

Annual Review of Genetics, Journal Year: 2023, Volume and Issue: 57(1), P. 87 - 115

Published: June 29, 2023

Coral reefs are both exceptionally biodiverse and threatened by climate change other human activities. Here, we review population genomic processes in coral reef taxa their importance for understanding responses to global change. Many on characterized weak genetic drift, extensive gene flow, strong selection from complex biotic abiotic environments, which together present a fascinating test of microevolutionary theory. Selection, hybridization have played will continue play an important role the adaptation or extinction face rapid environmental change, but research remains limited compared urgent needs. Critical areas future investigation include evolutionary potential mechanisms local adaptation, developing historical baselines, building greater capacity countries where most diversity is concentrated.

Language: Английский

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Long-term exhaustion of the inbreeding load in Drosophila melanogaster

Heredity, Journal Year: 2021, Volume and Issue: 127(4), P. 373 - 383

Published: Aug. 16, 2021

Inbreeding depression, the decline in fitness of inbred individuals, is a ubiquitous phenomenon great relevance evolutionary biology and fields animal plant breeding conservation. depression due to expression recessive deleterious alleles that are concealed heterozygous state noninbred so-called inbreeding load. Genetic purging reduces by removing these when expressed homozygosis inbreeding. It generally thought fast (such as generated full-sib mating lines) removes only highly alleles, while slow can also remove mildly ones. However, question remains regarding which proportion load be removed under moderately large populations. We report results two long-term Drosophila experiments (125-234 generations), each using population number derived lines with effective sizes about 1000 50, respectively. The was virtually exhausted after more than one hundred generations populations between few tens over lines. This result not expected from genetic drift alone, agreement theoretical predictions. Computer simulations suggest consistent model relatively mutations homozygous effects partially gene action.

Language: Английский

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Genomic erosion in the assessment of species extinction risk and recovery potential

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 15, 2022

Abstract Many species are facing unprecedented population size declines and deterioration of their environment. This exposes to genomic erosion, which we define here as the damage inflicted a species’ genome or gene pool due loss genetic diversity, an increase in expressed load, maladaptation, and/or introgression. The International Union for Conservation Nature (IUCN) bases its extinction risk assessments on direct threats habitat. However, it does not assess long-term impacts hence, is likely underestimate many species. High-quality whole sequence data that currently being generated could help improve assessments. Genomic contains information about past demography, genome-wide incidence introgression, well load deleterious mutations. Computer modelling these enables forecasting trajectories under different management scenarios. In this Perspective, discuss posed by erosion. Using evolutionary simulations, argue provides critical assessing recovery potential Genomics-informed complement IUCN Red List, such genomics-informed conservation invaluable guiding programs UN’s Decade Ecosystem Restoration beyond.

Language: Английский

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Small populations, big challenges: Genetic, demographic, and landscape context collectively shape population performance of a perennial herb

Biological Conservation, Journal Year: 2025, Volume and Issue: 305, P. 111044 - 111044

Published: March 3, 2025

Language: Английский

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Long-term storage does not affect the genetic diversity of pedunculate oak acorns; instead, the collection process is crucial

Forest Ecology and Management, Journal Year: 2025, Volume and Issue: 585, P. 122664 - 122664

Published: March 22, 2025

Language: Английский

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Time-lagged genomic erosion and future environmental risks in a bird on the brink of extinction

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2043)

Published: March 1, 2025

Global biodiversity is rapidly declining due to habitat degradation and genomic erosion, highlighting the urgent need monitor endangered species their genetic health. Temporal genomics ecological modelling offer finer resolution than single-time-point measurements, providing a comprehensive view of species’ recent future trajectories. We investigated erosion environmental suitability in critically regent honeyeater ( Anthochaera phrygia ) by sequencing whole genomes historical modern specimens building multi-temporal distribution models (SDMs) across last century. The has declined from hundreds thousands individuals fewer 300 over past 100 years. SDMs correctly predicted known patterns local extinction southeast Australia. Our demographic reconstructions revealed gradual population decline 2000 2500 years ago, sharply accelerating 500 climate variability loss. Despite this substantial collapse, lost only 9% its diversity, with no evidence inbreeding or connectivity Also, it exhibits higher diversity many other threatened bird species. Forward-in-time simulations indicate that time lag between loss conceals risk ongoing into degrading suitability. work underscores for targeted conservation efforts continuous monitoring prevent extinction.

Language: Английский

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Allele surfing causes maladaptation in a Pacific salmon of conservation concern

PLoS Genetics, Journal Year: 2023, Volume and Issue: 19(9), P. e1010918 - e1010918

Published: Sept. 8, 2023

How various factors, including demography, recombination or genome duplication, may impact the efficacy of natural selection and burden deleterious mutations, is a central question in evolutionary biology genetics. In this study, we show that key processes, variations i) effective population size (Ne) ii) rates iii) chromosome inheritance, have influenced genetic load Coho salmon (Oncorhynchus kisutch), widely distributed salmonid species on west coast North America. Using whole resequencing data from 14 populations at different migratory distances their southern glacial refugium, found evidence supporting gene surfing, wherein reduced Ne postglacial recolonization front, leads to decrease surf alleles northernmost populations. Furthermore, our results indicate play prime role shaping along genome. Additionally, identified variation polyploidy as contributing factor within-genome load. Overall, align remarkably well with expectations under nearly neutral theory molecular evolution. We discuss fundamental applied implications these findings for conservation genomics.

Language: Английский

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Population genetics of museum specimens indicate decreasing genetic resiliency: The case of two bumble bees of conservation concern

Biological Conservation, Journal Year: 2024, Volume and Issue: 291, P. 110453 - 110453

Published: Feb. 13, 2024

Language: Английский

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Bringing genomics to the field: An integrative approach to seed sourcing for forest restoration

Applications in Plant Sciences, Journal Year: 2024, Volume and Issue: 12(3)

Published: May 1, 2024

Global anthropogenic change threatens the health and productivity of forest ecosystems. Assisted migration reforestation are tools to help mitigate these impacts. However, questions remain about how approach sourcing seeds ensure high establishment future adaptability. Using exome-capture sequencing, we demonstrate a computational finding best n-sets from candidate list seed sources that collectively achieve genetic diversity (GD) minimal load (GL), while also increasing evolvability in quantitative traits. The benefits this three-part strategy (diversity-load-evolvability) increase near-term success boosting evolutionary potential respond stressors. Members Nature Conservancy Central Appalachian Spruce Restoration Initiative planted 58,000 seedlings across 255 acres. A subset was monitored for variation growth. results show gains GD relative GL increases seedling growth pooled vs. single-source restoration. No single "super source" observed planting sites; rather, monitoring pooling multiple helps higher GD:GL evolvability. Our study shows integrating genomics into local-scale restoration importance building partnerships between academic researchers applied conservation managers.

Language: Английский

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