Therapeutic effect of bosentan on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 18, 2025

Language: Английский

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Inhibitory effects of carbohydrazide indole derivative on micro-blood vessel growth using ex vivo, in vivo, and in vitro assays

In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

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Protective effect of orientin on diabetic nephropathy in rat models of high-fat diet and streptozotocin-induced diabetes

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

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The Possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: histological and Immunohistochemical study

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Methotrexate (MTX) is an antimetabolite drug utilized for managing a variety of cancers and autoinflammatory conditions. MTX may trigger detrimental effects in mout, h tissues, including salivary gland impairment. Bosentan (BOS), that blocks endothelin receptors, has strengthened antioxidant, anti-inflammatory, anti-apoptotic properties. The study aimed to estimate the protective effect BOS on MTX-exacerbated changes Wistar Albino rats. Thirty male rats were arbitrarily sorted into three groups ten animals each. control group received normal saline 18 days. (induction) (25 mg/kg) intraperitoneally 7th day experiment once daily 6 consecutive + (50 orally days: days before induction, 2-h after post-induction. Animals euthanized 19, tissues dissected biochemical, histopathological, immunohistochemical analyses. dramatically improved MTX-aggravated biochemical histopathological abnormalities, as evidenced by diminished Bax, caspase 3, TNF-α, IL-1β, MDA, MPO levels, increased SOD, GSH, GPX reduced degenerative granular convolute tubule, mucous acini, striate duct. further substantially upregulated MTX-induced decline Ki-67 Bcl-2, indicated immunohistochemistry scoring methods. anti-oxidative, ant-inflammatory, antiapoptotic properties are promising strategy ameliorating toxic submandibular glandular tissues.

Language: Английский

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Skin Healing Potential of Bioactive Components From Lycoperdon lividum Mushroom Versus β‐Sitosterol in Rat Model of Burn Wounds

Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

ABSTRACT Burn injury elicits an inflammatory response, metabolic abnormalities, and distributional shock leading to diverse organ dysfunctions with remarkable morbidity mortality. Sluggish wound healing, infections, hypertrophic scars still struggle in burn treatment. Lycoperdon lividum , a puffball mushroom enriched polyphenols, has outstanding antioxidative anti‐inflammatory properties. This study aimed assess the benefits of L. on second‐degree lesions rat model at 100°C. Seventy‐five male rats were haphazardly separated into five groups 15 each: Control (without any skin induction/treatment), (skin induction/non‐treated), β‐sitosterol (treated topical 0.25%), Vehicle Vaseline), watery extract 10%). Rats euthanized Days 5, 10, 20 experiment. was analyzed using HPLC techniques. Skin samples collected for microscopical histopathological examinations. Biomarkers involving IL‐6, IL‐10, TGF‐β1, TNF‐α, VEGF homogenates. The chromatogram revealed distinct peaks bioactive compounds including kaempferol, rutin, ferulic acid, caffeic chlorogenic quercetin, gallic acid. greatly alleviated via improving contraction, correcting inflammation, granulation aberrations while boosting fibrosis. outcomes validated by analyses. Further, markedly improved healing wounds regulating cytokines (IL‐6 TNF‐α), (IL‐10 TGF‐β1), angiogenic (VEGF) tissues. potential thanks its antioxidant actions.

Language: Английский

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The role of Juniperus Macrocarpa extract as anti-inflammatory and antioxidant on methotrexate-induced acute liver injury in rat model

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 131 - 131

Published: Jan. 27, 2025

Methotrexate (MTX) is an antifolate medication indicated to treat array of tumors and autoinflammatory maladies. MTX may exhibit harmful impacts on multiple organs, especially liver injury cirrhosis. Juniperus macrocarpa a medicinal herb enriched with polyphenols flavonoids featuring robust anti-inflammatory antioxidative benefits. To evaluate the hepatoprotective effects aqueous extract MTX-aggravated toxicity. The study involved 20 male middle-aged albino rats, arbitrarily allocated into 4 groups 5 animals each. Group 1 (control) were given distilled water (DW) once daily for two weeks. 2 got intraperitoneal single dose (20 mg/kg) Rats in 3 dosages 100 mg 200 extract, respectively, weeks before receiving injection. extracts at both low high doses substantially alleviated MTX-provoked biochemical alterations, as evidenced by decreased levels inflammatory parameters including TNF-α IL-6 hepatic enzymes ALT, AST, ALP. also significantly boosted anti-oxidant like SOD GPX. Moreover, attenuated congestive degenerative changes, improved histopathological findings. anti-oxidative activities are promising approach ameliorating hepatotoxicity.

Language: Английский

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The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 257 - 257

Published: March 4, 2025

Background Indomethacin (IND) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked the development gastric ulcers in many people. Cranberry is a rich source polyphenols flavonoids, which have powerful antioxidant properties. Methods This study aimed evaluate activity cranberry aqueous extract on IND-induced albino rats. Twenty-four adult male rats were sequentially assigned four groups six each. The control group consumes distilled water (DW) orally 15 days. IND (induction) received single oral dosage (60 mg/kg) IND. omeprazole (OMP) got 60 mg/kg as dose then 20 mg/kg/day OMP was given subsequently 200 Rats euthanized day 16, tissues removed biochemical histopathological evaluations. Results considerably ameliorated severity ulcerations fixed histological deteriorations. Furthermore, IND-exposed treated with exhibited dramatically lower serum levels inflammatory biomarkers like TNF-α IL-6, but higher anti-oxidative SOD GPx. bioactive flavonoids content could possibly account its profound gastroprotective effects. properties be promising strategy ameliorating IND-aggravated gastrotoxicity.

Language: Английский

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A Case Study on Complete Pathological Response in Advanced Rectal Cancer Patient with Oxaliplatin-based Chemotherapy without Cumulative Neurotoxicity

Journal of Gastrointestinal Cancer, Journal Year: 2025, Volume and Issue: 56(1)

Published: April 16, 2025

Language: Английский

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Vildagliptin topical ointment: an effective treatment for imiquimod-induced psoriasis in mice

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(3)

Published: April 26, 2025

Language: Английский

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