Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. While the adverse effects on oral have garnered increasing attention, comprehensive systematic assessment remains lacking. This article delves into intricate relationship between health, highlighting significant impacts various aspects such as dental caries, periodontal diseases, facial clefts, cancer, well other diseases. Our results suggested that secondhand smoke, particulate matters (PM) heavy metals are most important risk factors affecting health. Additional contributors, radiation pollutants, electronic cigarette, phthalates, gaseous air pesticides, solvents, wood dust, formaldehyde excessive fluoride were investigated, though evidence for their limited often inconclusive. review also explores potential mechanisms underlying these impacts, including microorganism, inflammation, oxidative stress, genetic influences, toxicant exposures from pollutants. For instance, PM2.5 may contribute caries by disrupting pH balance absorbing lead cadmium which been considered promoting elements. It associated with inflammatory responses tissue damage tissues causing potentially leading periodontitis. Drawing current evidence, it provides analysis associations, offering critical insights guide development preventive strategies interventions. findings highlight pressing need future research validate causal links diseases unravel biological mechanisms. Ultimately, greater attention must be directed toward addressing focus control reduction preventable risks safeguard broader scale.

Language: Английский

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Air Pollution and Oral Health: An Overall Insight From Genetic Causality

International Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

A growing body of epidemiological data consistently links air pollution to various adverse health outcomes. However, the potential connection between and risk oral diseases remains underexplored. This study utilized a two-sample Mendelian randomization approach assess causal relationship diseases. Six categories were considered as exposures: nitrogen oxides (NOx), dioxide (NO2), particulate matter (PM2.5, PM2.5-10, PM10), PM2.5 absorbance. The outcomes included 18 health-related drawn from Finngen R10 dataset, Gene-Lifestyle Interactions in Dental Endpoints consortium, Oncoarray cavity oropharyngeal cancer consortium. Sensitivity analyses performed validate primary inverse-variance weighted estimates using methods such median, mode, MR Egger. analysis demonstrated detrimental effect on multiple conditions, yielding 5 positive associations including with leukoplakia, gingivitis periodontitis; PM2.5-10 pulp periapical diseases, NO2 periodontitis, cavity, salivary glands jaws tests showed no evidence heterogeneity or pleiotropy, affirming robustness findings. highlights impact health, emphasizing need for further research into underlying mechanisms interactions. These findings reinforce importance implementing environmental interventions mitigate associated risks health.

Language: Английский

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Long-term exposure to ambient NO2 increase oral cancer prevalence in Southern China: a 3-year time-series analysis

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

While the correlation between cancer and air pollutants is well-established, research on delayed effects of NO2 oral remains limited. We collected data nitrogen dioxide (NO2) along with diagnosed cases in Guangxi, China, analyzed exposure to prevalence cancer. The study included 1,841 participants malignancies, consisting 1,179 males (64.0%) 662 females (36.0%), a mean age 55.9 ± 14.0 years. concentration 20.2 10.4 μg/m3. highest cumulative were observed at 3-year lag, relative risk (RR) 1.115 (95% CI: 1.102-1.128). For males, most pronounced effect also occurred lag (RR = 1.110, 95% 1.094-1.127). Similarly, among females, significant impact was found 1.123, 1.101-1.145). individuals under 60 years age, peaked same 1.102, 1.085-1.120). aged above, detected 1.132, 1.112-1.152). group normal BMI, period 1.289, 1.217-1.365), consistent findings for other groups. These suggest lagged long-term cancer, varying associations across different ages genders.

Language: Английский

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Associations between air pollution and daily outpatient visits for dry eye disease and the effect modification of temperature

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 27, 2025

Abstract Background Dry eye disease (DED) is one of the most common ocular surface disorders caused by various contributors. Air pollutants are considered a risk factor for diseases. We aimed to investigate associations between air (PM 2.5 , PM 10 NO 2 SO CO and O 3 ) constituents daily outpatient visits DED, as well modifying effect temperature on associations. Methods Daily data DED environmental variables during 2014–2019 were collected in Hangzhou, China. Distributed lag nonlinear models (DLNM) combined with time-stratified case-crossover design utilized evaluate effects 0‒3 days. Furthermore, we also estimated modification stratified median. The attributable fraction (AF) quantified. Stratified analyses gender, age, seasons conducted assess vulnerable population characteristics high-risk periods. Results Every interquartile range increase concentration significantly associated cases. AF 6.42% (95% CI: 1.09%, 11.58%), 8.00% (2.60%, 13.60%), 18.65% (11.52%, 25.21%), 10.82% (3.92%, 17.24%) 12.28% (0.23%, 22.86%), respectively. For constituents, − NH 4 + 4.34% (0.21%, 8.11%) 4.84% (0.18%, 9.09%), pollution significant low-temperature level CO; while statistically insignificant high-temperature level. Subgroup indicated present winter among patients aged 21–40 but other age groups. Conclusion Our results revealed that visits. Low temperatures might hazardous pollution. Besides, individuals pollution, was period. Clinical trial number Not applicable. Graphical abstract

Language: Английский

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A Proposal for a Predictive Model for the Number of Patients with Periodontitis Exposed to Particulate Matter and Atmospheric Factors Using Deep Learning

Journal of dental hygiene science, Journal Year: 2024, Volume and Issue: 24(1), P. 22 - 28

Published: March 29, 2024

Background: Particulate matter (PM) has been extensively observed due to its negative association with human health.Previous research revealed the possible effect of air pollutant exposure on oral health.However, predictive model between and prevalence periodontitis not yet.Therefore, this study aims propose a for number patients exposed PM atmospheric factors in South Korea using deep learning.Methods: This is retrospective cohort utilizing secondary data from Korean Statistical Information Service Health Insurance Review Assessment database pollution periodontitis, respectively.Data 2015 2022 were collected consolidated every month, organized by region.Following matching management, neural networks (DNN) was applied, mean absolute percentage error (MAPE) value calculated ensure accuracy model.Results: As we evaluated DNN MAPE, multivariate including PM2.5, PM10, other predict approximately 85% periodontitis.The MAPE ranged 12.85 17.10 (mean±standard deviation=14.12±1.30),indicating commendable level accuracy.Conclusion: In study, developed based pollution, factors.Additionally, various relevant are incorporated into elucidate specific causal relationships.It anticipated that future will lead development more accurate predicting periodontitis.

Language: Английский

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Association between blood ethylene oxide levels and the prevalence of periodontitis: evidence from NHANES 2013–2014

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(5)

Published: May 2, 2024

Language: Английский

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Periodontal conditions and salivary microbiota are potential indicators to distinguish silicosis: an exploratory study

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 28, 2024

Silicosis has always been a serious global occupational health problem. Oral microbiota plays important roles in the development of lung disease. However, few studies have investigated relationship between periodontal conditions, oral bacteria and silicosis A single-center cross-sectional study was conducted 2019 Sichuan Province, China, including small sample patient group healthy control group. Demographic data examinations measured by clinical attachment loss (CAL), bleeding on probing (BOP) pocket (PD) were collected from each participant. Phenotypic changes detected histopathological staining. Next-generation sequencing targeting 16S ribosomal RNA targeted to decipher salivary microbiome two groups. Random forest, Least Absolute Shrinkage Selection Operator (LASSO) logistic regression multivariable analysis find potential indicators distinguish silicosis. In general, 29 male controls 24 patients included. The proportion CAL ≥ 3 mm greater than group, while BOP (+) PD 4 reduced α-smooth muscle actin fibronectin expression increased gingiva patients. composition exhibited significant differences groups, with demonstrating lower diversity microbiota. Genus Aggregatibacter [odds ratio (OR) = 0.000, p 0.003] Catonella (OR 0.049) identified as biomarkers worse CAL, improved PD, which may be related gingival fibrosis found this study. underwent changes, accompanied decrease diversity, Our indicates that respirable crystalline silica exposure affects health, alterations might implicated We primarily controls.

Language: Английский

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Particulate Matter 2.5 and Severe Periodontitis Among Colombian Adults

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

The primary aim was to determine the association between particulate matter 2.5 (PM

Language: Английский

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