Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)
Published: March 24, 2025
Abstract Commercial decabromodiphenyl ether (c-decaBDE) is a widely used additive flame retardant in textiles and plastics. This formulation predominantly consists of the congener BDE-209, with trace amounts other brominated diphenyl congeners, such as nonabromodiphenyl octabromodiphenyl ether. Recognized persistent organic pollutant due to its potential for long-range environmental transport, c-decaBDE poses significant threats serious human health risks, including endocrine, reproductive, developmental, neurotoxic effects. The mechanisms underlying neurotoxicity remain largely undefined. study investigates effects BDE-209 humans through network toxicology, multi-level bioinformatics approaches, molecular docking analyses. Prediction results indicate that can cross blood-brain barrier, entering central nervous system inducing A comprehensive analysis has identified 294 targets linked induced by BDE-209. Gene-gene interaction pathway enrichment analyses revealed associations related cellular responses chemical stress synaptic transmission. Further investigation protein-protein interactions, combined centrality analysis, 14 hub targets, CaMK-II alpha, PSD-95, GluR-1, GluN2B, key proteins this process. Molecular exhibits stronger binding affinity subunit N-methyl-D-aspartate (NMDA) receptors, compared targets. These findings suggest may disrupt function GluN2B-containing NMDA potentially leading their inhibition. Such inhibition could result reduced excitatory neurotransmission, impairing potentiation plasticity, ultimately contributing neurotoxicity.
Language: Английский