New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress DOI Creative Commons

Huiying Zhao,

Fan Yu, Wei Wu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 605 - 605

Published: May 17, 2025

Estrogen levels are the core factor influencing postmenopausal osteoporosis (PMOP). can affect progression of PMOP by regulating bone metabolism, major signaling pathways related to and modulating immune responses. When estrogen decline, activity Sirtuins (SIRTs) is reduced. SIRTs enzymes that function as NAD+-dependent deacetylases. modulate osteocyte function, sustain mitochondrial homeostasis, relevant pathways, thereby improving metabolic imbalances, reducing resorption, promoting formation. In PMOP, SIRT1, SIRT3, SIRT6 primarily affected. Oxidative stress (OS) a crucial in it generates excessive reactive oxygen species (ROS) exacerbate PMOP. There certain interplay between OS. The reduced leads intensified OS accumulation ROS. return, ROS suppresses AMPK pathway synthesis NAD+, which consequently diminishes SIRTs. Natural SIRT activators natural antioxidants, characterized high safety, convenience, minimal side effects, represent potential therapeutic strategy for This study aims investigate mechanisms summarize strategies assist improvement

Language: Английский

New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress DOI Creative Commons

Huiying Zhao,

Fan Yu, Wei Wu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 605 - 605

Published: May 17, 2025

Estrogen levels are the core factor influencing postmenopausal osteoporosis (PMOP). can affect progression of PMOP by regulating bone metabolism, major signaling pathways related to and modulating immune responses. When estrogen decline, activity Sirtuins (SIRTs) is reduced. SIRTs enzymes that function as NAD+-dependent deacetylases. modulate osteocyte function, sustain mitochondrial homeostasis, relevant pathways, thereby improving metabolic imbalances, reducing resorption, promoting formation. In PMOP, SIRT1, SIRT3, SIRT6 primarily affected. Oxidative stress (OS) a crucial in it generates excessive reactive oxygen species (ROS) exacerbate PMOP. There certain interplay between OS. The reduced leads intensified OS accumulation ROS. return, ROS suppresses AMPK pathway synthesis NAD+, which consequently diminishes SIRTs. Natural SIRT activators natural antioxidants, characterized high safety, convenience, minimal side effects, represent potential therapeutic strategy for This study aims investigate mechanisms summarize strategies assist improvement

Language: Английский

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