The role of long non‐coding RNAs in the development of diabetic kidney disease and the involved clinical application DOI
Qizhuo Hou, Bin Yi

Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(4)

Published: May 1, 2024

Abstract Diabetic kidney disease (DKD), one of the common microvascular complications diabetes, is increasing in prevalence worldwide and can lead to End‐stage renal disease. However, there are still gaps our understanding pathophysiology DKD, both current clinical diagnostic methods treatment strategies have drawbacks. According recent research, long non‐coding RNAs (lncRNAs) intimately linked developmental process DKD could be viable targets for decisions therapeutic interventions. Here, we review insights gained into lncRNAs pathological changes such as mesangial expansion, podocyte injury, tubular interstitial fibrosis. We also discuss applications DKD‐associated biomarkers targets, well their limitations challenges, provide new prevention, diagnosis, DKD.

Language: Английский

Pharmacological roles of lncRNAs in diabetic retinopathy with a focus on oxidative stress and inflammation DOI
Cheng-Ming Chen, Peng Ding, Weiming Yan

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 214, P. 115643 - 115643

Published: June 13, 2023

Language: Английский

Citations

21
Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes DOI Creative Commons
Tarun Pant, Nnamdi Uche, Matea Juric

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 898 - 898

Published: April 7, 2023

Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such diabetic nephropathy, cardiomyopathy, neuropathy, retinopathy. Therefore, specific therapeutic approaches capable modulating oxidative milieu may provide a preventative and/or benefit against cardiovascular patients. Recent studies have demonstrated epigenetic alterations circulating tissue-specific long non-coding RNA (lncRNA) signatures DM regulating function under stress. Intriguingly, over past decade mitochondria-targeted antioxidants (MTAs) emerged promising option managing stress-induced diseases. Here, we review present status lncRNA diagnostic biomarker potential regulator stress DM. We also discuss recent advances using MTAs different animal models clinical trials. summarize prospects challenges use treating diseases their application translation medicine, which be beneficial MTA drug design development, translational medicine.

Language: Английский

Citations

20
Inhibition of METTL3 alleviated LPS-induced alveolar epithelial cell apoptosis and acute lung injury via restoring neprilysin expression DOI Open Access

Jingsi Jia,

Yu Yuan,

Yi He

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 333, P. 122148 - 122148

Published: Oct. 5, 2023

Language: Английский

Citations

12
Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL DOI
S Zou Alfaghari Anaraki, Masoumeh Kheirandish, Pegah Mousavi

et al.

Gene, Journal Year: 2024, Volume and Issue: 911, P. 148319 - 148319

Published: Feb. 28, 2024

Language: Английский

Citations

4
Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases DOI

Feiyan Shou,

Gang Li,

Mohammadamin Morshedi

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7919 - 7929

Published: March 5, 2024

Language: Английский

Citations

4
Forsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition DOI Creative Commons

Xiaohong Quan,

Huihui Liu, Dongmei Ye

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2021, Volume and Issue: Volume 14, P. 1885 - 1895

Published: April 1, 2021

Podocyte injury serves an important role during the progression of diabetic nephropathy (DN). The aim this study was to investigate effects forsythoside A (FA) on high glucose (HG)-induced podocyte and identify possible mechanisms.MPC-5 podocytes were cultured under HG conditions. After exposure different doses FA, cell viability apoptosis respectively evaluated with CCK-8 assay flow cytometry. Then, levels oxidative stress-related markers inflammatory factors examined by corresponding kits. Western blot analysis employed detect expression Nox2, Nox4, COX-2, iNOS matrix metalloproteinases 12 (MMP12). Subsequently, MMP12 overexpressed assess whether FA HG-stimulated mediated MAPK signaling.Results indicated that dose-dependently elevated viability, reduced in HG-induced MPC-5 cells. Additionally, significantly inhibited stress, which could be certified decreased content malondialdehyde (MDA), enhanced activities superoxide dismutase (SOD) catalase (CAT), downregulated Nox2 Nox4. Moreover, notably tumor necrosis factor (TNF)-α, interleukin (IL)-1β IL-6 observed FA-treated cells conditions, accompanied COX-2 expression. Remarkably, suppressed a dose-dependent manner, exposed partially counteracted overexpression. Mechanically, inactivated phospho-ERK (p-ERK), p-p38 p-JNK, restored after overexpression.These findings demonstrate protective mechanism inactivating signaling via inhibition injury, providing promising therapeutic candidate for treatment DN.

Language: Английский

Citations

25
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation DOI
Jie Feng, Liyi Xie, Xiaoyang Yu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2021, Volume and Issue: 544, P. 22 - 30

Published: Jan. 28, 2021

Language: Английский

Citations

24
Understanding the lncRNA/miRNA-NFκB regulatory network in diabetes mellitus: From function to clinical translation DOI

Parisa Hoorzad,

Fatemehsadat Mousavinasab,

Pouya Tofigh

et al.

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 202, P. 110804 - 110804

Published: June 25, 2023

Language: Английский

Citations

10
Finerenone Ameliorates High Glucose-Induced Podocytes Epithelial-Mesenchymal Transition Through the Regulation of Krüppel-Like Factor 5 in Diabetic Nephropathy DOI Creative Commons
Jianqiang Shu,

Dandan Chen,

Wenzhen Chen

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 637 - 651

Published: Feb. 1, 2025

Diabetic nephropathy (DN) could impair the function of glomerular filtration barrier by damaging podocytes. Extant research has demonstrated that aldosterone plays a crucial role in this progression. Finerenone is novel, high-selective mineralocorticoid receptor antagonist been to be efficacious renal protection DN patients, albeit with an unclear underlying mechanism. Podocytes were stimulated RPMI 1640 medium containing different concentrations glucose and treated finerenone evaluate protective effect on podocytes high environment. Intraperitoneal injection STZ was used induce diabetic rats intragastric administration or vehicles, changes function, pathological tissue protein expression assayed. Cell experiment showed epithelial-mesenchymal transition (EMT). After treatment, we accessed EMT-related found EMT reversed. Besides, cell migration capacity cytoskeleton also ameliorated. To further explore mechanism, upregulate Krüppel-like factor 5 (KLF5) which downregulated silence KLF5 presence finerenone, rescue counteracted KLF5. In animal experiment, after treatment level blood creatinine decreased compared group while urea nitrogen (BUN) potassium no significant difference. The alterations got normalize protein, nephrin, kidney rats. Our results suggest alleviate glucose-induced podocyte via regulating Further investigation warranted elucidate precise

Language: Английский

Citations

0
Genetic association of long non-coding RNA ANRIL polymorphism with the risk of type 2 diabetes mellitus in the Chinese Han population DOI Creative Commons
Xinyi Li,

Aige Yang,

Xiao Liu

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 28, 2025

Language: Английский

Citations

0