Dysregulation of neutrophil in sepsis: recent insights and advances

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

Sepsis remains the leading cause of death in intensive care units. Despite newer antimicrobial and supportive therapies, specific treatments are still lacking. Neutrophils pivotal components effector phase host immune defense against pathogens play a crucial role control infections under normal circumstances. In addition to its anti-infective effects, dysregulation overactivation neutrophils may lead severe inflammation or tissue damage potential mechanisms for poor prognosis sepsis. This review focuses on recent advancements understanding functional status across various pathological stages sepsis explore by which participate progression provide insights treatment targeting neutrophils.

Language: Английский

Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning

Molecular Immunology, Journal Year: 2025, Volume and Issue: 183, P. 44 - 55

Published: May 2, 2025

Language: Английский