Mitochondrial quality control and transfer communication in neurological disorders and neuroinflammation DOI Creative Commons

Yinrui Ma,

Rui Song, Chenyang Duan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Mitochondria, as the primary energy factories of cells, play a pivotal role in maintaining nervous system function and regulating inflammatory responses. The balance mitochondrial quality control is critical for neuronal health, disruptions this are often implicated pathogenesis various neurological disorders. Mitochondrial dysfunction not only exacerbates deficits but also triggers neuroinflammation through release damage-associated molecular patterns (DAMPs), such DNA (mtDNA) reactive oxygen species (ROS). This review examines mechanisms recent advancements diseases, focusing on processes fusion fission, mitophagy, biogenesis, protein expression regulation. It further explores subsequent cascades conditions ischemic hemorrhagic stroke, neurodegenerative diseases brain tumors. Additionally, emerging research highlights significance transfer mechanisms, particularly intercellular between neurons glial potential strategy mitigating inflammation promoting cellular repair. provides insights into underpinnings neuroinflammatory pathologies while underscoring translational targeting therapeutic development.

Language: Английский

Mitochondria and astrocyte reactivity: Key mechanism behind neuronal injury DOI
Patricia Cassina, Ernesto Miquel, Laura Martìnez‐Palma

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 227 - 234

Published: Jan. 7, 2025

Language: Английский

Citations

0
Mitochondrial quality control and transfer communication in neurological disorders and neuroinflammation DOI Creative Commons

Yinrui Ma,

Rui Song, Chenyang Duan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Mitochondria, as the primary energy factories of cells, play a pivotal role in maintaining nervous system function and regulating inflammatory responses. The balance mitochondrial quality control is critical for neuronal health, disruptions this are often implicated pathogenesis various neurological disorders. Mitochondrial dysfunction not only exacerbates deficits but also triggers neuroinflammation through release damage-associated molecular patterns (DAMPs), such DNA (mtDNA) reactive oxygen species (ROS). This review examines mechanisms recent advancements diseases, focusing on processes fusion fission, mitophagy, biogenesis, protein expression regulation. It further explores subsequent cascades conditions ischemic hemorrhagic stroke, neurodegenerative diseases brain tumors. Additionally, emerging research highlights significance transfer mechanisms, particularly intercellular between neurons glial potential strategy mitigating inflammation promoting cellular repair. provides insights into underpinnings neuroinflammatory pathologies while underscoring translational targeting therapeutic development.

Language: Английский

Citations

0