Life’s Crucial 9 and psoriasis: a mediation analysis of systemic inflammation response index using NHANES cohort data DOI Creative Commons
Xinyan Liu,

Qirui Deng,

Hongfeng Tang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Psoriasis is a chronic, recurrent, inflammatory disease. The aim of this study was to investigate the association between Life’s Crucial 9 (LC9) score and risk psoriasis examine mediating role system inflammation response index (SIRI). Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2009 2014, employed multifactor logistic regression, restricted triple spline analysis, various subgroup analyses evaluate correlation LC9 scores occurrence psoriasis. Furthermore, mediation were executed SIRI’s possible intermediary effect in linkage Results This included 11,499 US adults with 345 patients. In fully adjusted models, notable inverse relationship identified prevalence (OR = 0.90, 95% CI: 0.80, 0.99). After adjusting for all covariates, no significant interactions found analyses. addition, analysis showed that SIRI mediated (mediation ratio: 7.02%, p 0.004). Conclusions Higher reduce And, by SIRI. suggests we should actively regulate our lifestyles improve cardiovascular health, thereby preventing delaying onset

Language: Английский

Life’s Crucial 9 and psoriasis: a mediation analysis of systemic inflammation response index using NHANES cohort data DOI Creative Commons
Xinyan Liu,

Qirui Deng,

Hongfeng Tang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Psoriasis is a chronic, recurrent, inflammatory disease. The aim of this study was to investigate the association between Life’s Crucial 9 (LC9) score and risk psoriasis examine mediating role system inflammation response index (SIRI). Methods Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2009 2014, employed multifactor logistic regression, restricted triple spline analysis, various subgroup analyses evaluate correlation LC9 scores occurrence psoriasis. Furthermore, mediation were executed SIRI’s possible intermediary effect in linkage Results This included 11,499 US adults with 345 patients. In fully adjusted models, notable inverse relationship identified prevalence (OR = 0.90, 95% CI: 0.80, 0.99). After adjusting for all covariates, no significant interactions found analyses. addition, analysis showed that SIRI mediated (mediation ratio: 7.02%, p 0.004). Conclusions Higher reduce And, by SIRI. suggests we should actively regulate our lifestyles improve cardiovascular health, thereby preventing delaying onset

Language: Английский

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