Genomic study of taste perception genes in African Americans reveals SNPs linked to Alzheimer’s disease DOI Creative Commons
Paule V. Joseph, Malak Abbas, Gabriel Goodney

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 16, 2024

While previous research has shown the potential links between taste perception pathways and brain-related conditions, area involving Alzheimer's disease remains incompletely understood. Taste involves neurotransmitter signaling, including serotonin, glutamate, dopamine. Disruptions in these are implicated neurodegenerative diseases. The integration of olfactory signals flavor may impact brain health, evident dysfunction as an early symptom conditions. Shared immune response inflammatory contribute to association altered conditions like neurodegeneration, present disease. This study consists exploration expression-quantitative trait loci (eQTL), utilizing whole-blood transcriptome profiles, 28 genes, from a combined cohort 475 African American subjects. comprehensive dataset was subsequently intersected with single-nucleotide polymorphisms (SNPs) identified Genome-Wide Association Studies (GWAS) Disease (AD). Finally, investigation delved into assessing eQTLs reported GWAS AD profiles 741 proteins Olink Neurological Panel. eQTL analysis unveiled 3,547 statistically significant SNP-Gene associations, 412 distinct SNPs that spanned all genes. In 17 studies encompassing various traits, total 14 associated 12 genes were identified, three consistently linked across four studies. All demonstrated associations down-regulation TAS2R41, two them additionally TAS2R60. subsequent pQTL analysis, TAS2R41 TAS2R60 (rs117771145 rs10228407) correlated upregulation proteins, namely EPHB6 ADGRB3. Our introduces new perspective understanding disease, emphasizing significance bitter receptor its pathogenesis. These discoveries set stage for delve receptors promising avenues both intervention diagnosis. Nevertheless, translation genetic insights clinical practice requires more profound their pertinence disease's progression diverse populations.

Language: Английский

Inflammation and arrhythmogenesis: a narrative review of the complex relationship DOI Creative Commons
Andia Taghdiri

International Journal of Arrhythmia, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 7, 2024

Abstract Background A biological mechanism called inflammation is necessary for reacting to damaging stimuli, but it can also, ironically, play a role in the formation of arrhythmias, or group disorders known as arrhythmogenesis. This review delves into intricate relationship that exists between localized and systemic electrophysiological changes result abnormal heart rhythms. Main body Through oxidative stress, autonomic dysfunction, electrolyte imbalances, coagulation activation, may impact arrhythmogenicity. Similar neuropathic alterations, direct cellular damage, structural remodeling, also predisposes arrhythmias. Studies demonstrating cytokines on ion channel expression function, along with clinical associations inflammatory indicators arrhythmia incidence, offer molecular insights. Immune cells like macrophages alter cardiac conduction are involved interaction electrophysiology, which further complicates situation. Clinical ramifications include use anti-inflammatory drugs treat arrhythmic episodes possible adjustment treatment based condition. Even yet, thorough study fully understand efficacy these medicines. Conclusions Arrhythmogenesis inherently linked by number mechanisms change electrical characteristics heart. Arrhythmia prevention benefit from therapeutic approaches reduce processes. The difficulties still exist applying this information settings highlight necessity continuing studies better comprehend subtleties inflammation-induced alterations. Progress identifying biomarkers developing tailored therapies will be crucial enhancing prognosis individuals suffering arrhythmogenic aggravated inflammation.

Language: Английский

Citations

5
The material basis of bitter constituents in Carbonized Typhae Pollen, based on the integration strategy of constituent analysis, taste sensing system and molecular docking DOI

Derong Kong,

Ying Zhang, Xinyue Li

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 242, P. 116028 - 116028

Published: Feb. 14, 2024

Language: Английский

Citations

5
The appearance of bitter taste receptors — inspiration from structure, expression, function, and mechanism DOI

Furong Yang,

Ming Zhang, Xiangdong Pu

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
Panaxynol from dietary sources modulates ferroptosis through ceRNA networks in synovium: A novel strategy for alleviating rheumatoid arthritis through functional food intervention DOI

Xialin Sun,

Jinlong Liu, Shijie Wang

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Panaxynol (PAL), a bioactive polyacetylene abundant in dietary plants such as carrots and ginseng, has shown potential mitigating immune-related diseases, including rheumatoid arthritis (RA).

Language: Английский

Citations

0
Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications DOI Creative Commons
Enriqueta García-Gutiérrez, A. Kate O’Mahony, Reinaldo S. Dos Santos

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 18, 2024

Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), 2 (T2D) gestational (GDM). T1D T2D chronic diseases affecting around 537 million adults worldwide it is projected that these numbers will increase by 12% over the next two decades, while GDM affects up to 30% women during pregnancy, depending diagnosis methods. These have varied origins: an autoimmune disease, commonly associated with, but not limited to, certain lifestyle patterns result a combination genetic predisposition pregnancy factors. Despite some pathogenic differences among diabetes, there markers with their development. For instance, gut barrier impairment inflammation unbalanced microbiota metabolites may factors in development progression. Here, we summarize microbial signatures been linked how they connected diet and, ultimately, impact metabolite profiles resulting from host-gut microbiota-diet interactions. Additionally, recent advances relating promising preventive therapeutic interventions focusing targeted modulation alleviate T1D, GDM.

Language: Английский

Citations

3
Bitter Taste Receptor 46 (hTAS2R46) Protects Monocytes/Macrophages from Oxidative Stress DOI Open Access
Maria Talmon, Lara Camillo,

Ilaria Vietti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7325 - 7325

Published: July 3, 2024

Bitter taste receptors (TAS2Rs) are not only responsible for perception in the oral cavity, but spread throughout body, generating a widespread chemosensory system. In humans, 25 subtypes have been identified and differentially expressed tissues organs, including immune fact, several TAS2R detected neutrophils, lymphocytes, B T cells, NK monocytes/macrophages, which they regulate various protective functions of innate Given its recognized anti-inflammatory antioxidant activity, generally role bitter receptors, this work, we studied TAS2R46's potential protection human monocyte/macrophage DNA from stress-induced damage. Through both direct indirect assays single-cell gel electrophoresis assay, demonstrated that absinthin, specific TAS2R46 agonist, counteracts release reactive oxygen species (ROS) nitrogen (RNS) reduces damage cell types. Even though ROS monocytes/macrophages is fundamental contrast pathogen agents, supraphysiological production impairs their function, finally leading to death. Our results highlight as novel player involved monocytes macrophages oxidative stress damage, while simultaneously supporting antimicrobial activity.

Language: Английский

Citations

2
Berberine ameliorates dextran sulfate sodium -induced colitis through tuft cells and bitter taste signalling DOI Creative Commons
Yuxuan Yang, Wenqing Li,

Kaineng Sun

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 2, 2024

Language: Английский

Citations

2
Comparative Analysis of Whole Transcriptome Profiles in Septic Cardiomyopathy: Insights from CLP- and LPS-Induced Mouse Models DOI Open Access
Karim Ullah, Yan Li, Qiaoshan Lin

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1366 - 1366

Published: June 28, 2023

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, with septic cardiomyopathy being common and severe complication. Despite its significant clinical impact, the molecular mechanisms underlying sepsis-induced (SICM) remain incompletely understood. In this study, we performed comparative analysis of whole transcriptome profiles using RNA sequencing in mouse hearts two widely used models cardiomyopathy. CLP-induced sepsis was achieved surgical cecal ligation puncture, while LPS-induced induced 5 mg/kg intraperitoneal (IP) injection lipopolysaccharide (LPS). For consistency, utilized sham-operated mice as control for models. Our aim identify key genes pathways involved development evaluate similarities differences between findings demonstrated that both CLP LPS methods could induce heart within 24 h. We identified transcriptional regulatory regions models, such Nfkb1, Sp1, Jun. Moreover, differentially expressed (DEGs) comparison were shared pathways, including regulation inflammatory response, reactive oxygen species metabolic process, JAK-STAT signaling pathway. However, each model presented distinctive expression potentially diverse contributing failure. This extensive enhances our understanding basis cardiomyopathy, providing invaluable insights. Accordingly, study also contributes pursuit effective personalized treatment strategies SICM, highlighting importance considering specific causative factors.

Language: Английский

Citations

5
Prognosis of Older Adult Patients Suffering from Atrial Fibrillation and Hypokalemia DOI Creative Commons
Xuedong Wang, Yu Wang, Jing Liu

et al.

Clinical Interventions in Aging, Journal Year: 2023, Volume and Issue: Volume 18, P. 1363 - 1371

Published: Aug. 1, 2023

To examine the effects of hypokalemia on prognosis older adult patients with atrial fibrillation (AF).We enrolled 794 ≥ 75 years suffering from AF, and divided them into two groups according to inclusion exclusion criteria: Group 1, (hypokalemia group), 246 cases, serum K+<3.5 mmol/L; 2, (normal blood potassium 548 3.5mmol/L≤serum K+<5.5 mmol/L. The were followed for 70 months observe occurrence clinical events. primary endpoint was cardiovascular death secondary all-cause death.The median follow-up time 15.00 months. In terms baseline profile characteristics, creatinine levels significantly lower in 1 than 2 (P=0.002). relationship between outcomes, Kaplan-Meier survival analysis revealed that incidence higher (P < 0.001), did not differ (P> 005). Based multivariate Cox regression risk model analysis, coronary heart disease, hemoglobin content, uric acid usage anticoagulant drugs independent variables related (all P< 0.01).The AF 30.98%. Hypokalemia closely death, level, factors event.

Language: Английский

Citations

5
G protein‐coupled receptor‐mediated autophagy in health and disease DOI Creative Commons
Devrim Öz Arslan, Zeynep A. Oztug Durer, Beki Kan

et al.

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: March 19, 2024

G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These are involved in a wide range physiological functions targets for more than third available drugs market. Autophagy is cellular process degrading damaged proteins organelles recycling components. Deficiencies autophagy variety pathological conditions. Both GPCRs essential preserving homeostasis cell survival. There emerging evidence suggesting that direct regulators autophagy. Additionally, autophagic machinery regulation GPCR signalling. The interplay between signalling mechanisms significantly impacts on health disease; however, there still an incomplete understanding underlying therapeutic implications different tissues disease contexts. This review aims to discuss interactions Studies muscarinic receptors, beta‐adrenoceptors, taste purinergic adhesion summarized, relation

Language: Английский

Citations

1