Trajectories of mental health outcomes following COVID-19 infection: a prospective longitudinal study

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 13, 2024

The COVID-19 pandemic has triggered a global mental health crisis. Yet, we know little about the lasting effects of infection on health. This prospective longitudinal study aimed to investigate trajectories changes in individuals infected with and identify potential predictors that may influence these changes.

Language: Английский

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Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 9, 2025

Abstract Background Post-COVID condition (PCC) is characterized by persisting symptoms after the resolution of acute COVID-19. Remdesivir (RDV), a broad-spectrum antiviral drug, has been widely used in patients hospitalized with COVID-19 requiring oxygen therapy. We aimed to evaluate effects RDV on PCC assessing patient-reported and functional outcomes. Methods data from single-center registry, including formerly post-COVID ( N = 293). Propensity score matching (PSM) was (16 criteria, 1:1 ratio) obtain two comparable groups: those who received standard-of-care (SOC, 94) treated addition SOC (SOC + RDV, 94). Primary outcomes were asymptomatic status at least 50% symptom reduction follow-up. Secondary included results pulmonary function (PF) tests, 6-minute walk test (6MWT), quality-of-life (QoL) questionnaires. Results After PSM, baseline patient characteristics showed no significant differences between groups. Most still symptomatic (60% vs. 66%). In group, use supplementation (94 80%, p 0.005) steroids (97 88%, 0.027) during infection higher, while presented their visits earlier (median 68 97 days, 0.003). Complete or reported significantly stage group compared (multivariable-adjusted HR 2.28, 95% CI 1.33–3.92, 0.003; 2.08, 1.43–3.02, < 0.001; respectively). fewer experienced sleep disturbances PCC, sleep-related questionnaires (Pittsburg Sleep Quality Index, PSQI) better quality (14 27% 5.9 7.7 points, There notable PF 6MWT, other QoL Conclusion this propensity matched cohort, associated period, there Our indicate possible beneficial effect terms faster COVID19 infection. Graphical abstract

Language: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

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Prevalence of sleep disturbances in patients with long COVID assessed by standardised questionnaires and diagnostic criteria: A systematic review and meta-analysis

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 175, P. 111535 - 111535

Published: Oct. 22, 2023

We aimed to study the prevalence of sleep disturbances in patients with long COVID-19.We conducted a systematic review and meta-analysis pooled post COVID-19. systematically searched relevant studies from three databases, including Medline, Embase Scopus. Original articles were included based on specific criteria: peer-reviewed, observational involving adults (18 or older) confirmed COVID-19 status through PCR testing focused context Exclusion criteria non-English articles, insufficient data, narrative/systematic reviews. The search was performed 31st July 2023 15th August 2023. identified 35 eligible papers; however, we excluded 6 which did not describe assessment. used random-effects model estimate disturbances.29 involved 13,935 patients; approximately 39% participants male aged 18 97 years. overall disturbance 46% (95% CI: 38-54%). Subgroup analyses revealed that poor quality 56% 47-65%). insomnia 38% 28-48%). Finally, excessive daytime sleepiness 14% 0-29%).Sleep are common patients. healthcare sector should recognise these issues provide an early, effective treatment prevent long-term sequelae problems.

Language: Английский

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The influence of social support on sleep and fatigue level among patients receiving hemodialysis in Saudi Arabia: a cross-sectional correlational design

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 12, 2023

Background Patients on hemodialysis (HD) are more likely to experience sleep problems and fatigue that may affect their health outcomes. Management of these patients with social support improve quality as well health. Aim This study aimed assess the influence levels among HD patients. Methods A cross-correlational was conducted 260 conveniently sampled from four dialysis centers in Hail Al-Qassim cities Saudi Arabia Jun 2022 January 2023. Besides sociodemographic data, Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment Fatigue (MAF) Oslo Social Support Scale (OSSS-3) were used quality, support, respectively. Chi-square test determine association between categorical variables, while Pearson’s correlation coefficient fatigue, support. Results Poor high significantly higher older compared younger ( p &lt;0.001), strong lower than middle-aged ones = 0.001). On other hand, poor males females 0.022 &lt;0.001, respectively), &lt;0.001). Married showed poorer single 0.019), but received stronger Retired sleep, weaker groups There a significant negative patients, where had r −0.510, positive found normal 0.415, However, −0.479, Conclusion who have better reduced those less is need design implement intervention studies structured programs, evaluate effectiveness improving reducing

Language: Английский

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Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron—results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)

Infection, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Purpose The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined prevalence and predictors PCC-related symptoms in patients infected with delta or omicron. Methods We compared prevalences risk factors acute three months after primary infection (3MFU) between delta- omicron-infected from Cross-Sectoral Platform German National Pandemic Cohort Network. Health-related quality life (HrQoL) was determined by EQ-5D-5L index score trend groups were calculated to describe changes HrQoL different time points. Results considered 758 for our analysis (delta: n = 341; omicron: 417). Compared omicron patients, had a similar PCC at 3MFU (p 0.354), whereby fatigue occurred most frequently (n 256, 34%). comparable lowest (0.75, 95% CI 0.73–0.78) disease onset. While (69%, 348) never showed declined HrQoL, it deteriorated substantially 37 (7%) phase which 27 Conclusion With quality-controlled data multicenter cohort, that is an equally common challenge least population. Developing over two thirds did not experience any restrictions their due 3MFU. Clinical Trail registration cohort registered ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).

Language: Английский

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A blood supply pathophysiological microcirculatory mechanism for the Long COVID

Published: July 30, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Language: Английский

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Long COVID across SARS‐CoV‐2 variants: Clinical features, pathogenesis, and future directions

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Long coronavirus disease (COVID) is characterized by persistent symptoms following severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection and has emerged as a significant health concern. As SARS‐CoV‐2 evolved from the wild‐type strain to Alpha, Beta, Delta, Omicron variants, there may be variant‐specific influence on long COVID akin disease. This review aims summarize our current knowledge of influences in incidence, symptom profile well mechanisms pathogenesis. We highlight that incidence lower with variants. The also show some dependence different reduction cardiopulmonary more recent heterogeneity related differences affecting immune system, viral persistence, autoimmunity. However, emerging data suggest vaccinations play big role shaping presentation COVID. ongoing work profiles populations infected only will beneficial toward useful definitions development effective diagnostic therapeutic strategies.

Language: Английский

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Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279

Published: Feb. 1, 2025

Language: Английский

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Long COVID has variable incidence and clinical presentations: our 6-country collaborative study

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

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