Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Introduction: Parkinson's disease (PD) is characterized by motor and non-motor symptoms such as tremors, difficulty in initiating movements, depression, cognitive deficits. The pathophysiology of PD involves a gradual decrease dopaminergic neurons the substantia nigra, increased inflammatory parameters, augmented oxidative stress this region. Several new therapies aim to promote antioxidant anti-inflammatory actions, including use cannabinoids, particularly cannabidiol (CBD). CBD non-psychotomimetic component Cannabis sativa that acts broadly through several mechanisms. Objective: objective study was investigate potential protective effect mice subjected low-dose (0.1 mg/kg) repeated reserpine protocol, which encompasses behavioral neuronal alterations compatible with progressiveness alterations. Materials Methods: We used two approaches: (1) concurrent administration during development parkinsonism (2) pre-administration explore possible preventive action. (0.5 on reserpine-induced investigated (catalepsy vacuous chewing movements) (immunolabeling for tyrosine hydroxylase - TH) parameters. Results: Overall, groups were treated presented later protocol compared received only (except evaluation concomitant treatment). Additionally, attenuated catalepsy (preventive treatment) prevented TH labeling nigra pars compacta both protocols. Conclusion: Based these data, we observed beneficial progressive parkinsonism, after treatment.

Language: Английский

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Calprotectin in Parkinsonian disease: Anticipation and dedication

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102143 - 102143

Published: Nov. 25, 2023

Language: Английский

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The neuroprotective effect of vitamin D in Parkinson's disease: association or causation

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(8), P. 870 - 886

Published: Sept. 20, 2023

ABSTRACTParkinson's disease (PD) is a chronic neurodegenerative (NDD) due to the degeneration of dopaminergic neurons (DNs) in substantia nigra (SN). PD characterized by diverse motor symptoms such as rigidity, resting tremors, and bradykinesia, non-motor cognitive dysfunction sleep disturbances. Vitamin D (VD), VD receptor (VDR), metabolites are present brain play role maintaining development, differentiation, functions DNs. VDRs exert protective effects against neuropathology modulating functional capacity DNs neurotransmission SN. In virtue its anti-inflammatory antioxidant activities, could be effective prevention treatment PD. exerts neuroprotective effect reducing oxidative stress mitochondrial dysfunction, increasing autophagy brain-derived neurotrophic factor (BDNF). Low serum level connected with development dementia The VD-mediated augmenting interrelated safeguarding synaptic plasticity modulation neurotransmitter release. deficiency linked severity olfactory which precedes progression symptomatic However, precise remains unidentified, there conflict about whether can ameliorate or not.KEYWORDS: Parkinson's diseaseVitamin DVD receptorBDNFsubstantia nigraAutophagyOxidative stressdopaminergic AcknowledgementsNot applicable.Authors' contributionsAAH conceptualized manuscript, wrote, edited, reviewed main text approved final edition manuscript.Disclosure statementNo potential interest was reported author(s).Additional informationFundingThe author(s) no funding associated work featured this article.

Language: Английский

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Classification of Oral Ulcers and its Treatment by focusing on Exosome Loaded Hydrogel: A Comprehensive Review

Journal of Health and Rehabilitation Research, Journal Year: 2024, Volume and Issue: 4(2), P. 820 - 830

Published: May 21, 2024

Background: Oral ulcers significantly impact patient quality of life, manifesting as acute or chronic lesions that can cause considerable discomfort and pain. These arise from a variety etiological factors disrupt daily activities due to the painful loss mucosal tissue. Objective: This review aims elucidate etiology management oral ulcers, with focus on innovative treatment modalities involving hydrogels exosomes. Methods: We reviewed current literature pathology ulcers. Special attention was given properties exosomes, their biomedical applications, roles in new therapeutic strategies for Results: Hydrogels, biocompatibility, biodegradation, controlled release properties, have emerged effective drug delivery systems. Exosomes, loaded within these hydrogels, enhance outcomes high cellular communication capacity anti-inflammatory properties. Conclusion: Innovative treatments utilizing exosomes offer promising alternatives potentially improving efficiency compliance.

Language: Английский

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Repurposing celecoxib as adjuvant therapy in patients with Parkinsonian disease: a new therapeutic dawn: randomized controlled pilot study

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

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