Nutrients,
Journal Year:
2024,
Volume and Issue:
16(20), P. 3448 - 3448
Published: Oct. 11, 2024
Background:
Energy
expenditure
(EE)
in
patients
with
aneurysmal
subarachnoid
hemorrhage
(SAH)
may
differ
from
other
intracranial
pathologies,
such
as
intracerebral
(ICH)
or
traumatic
brain
injury
(TBI),
due
to
an
activation
of
the
sympathetic
nervous
system.
Indirect
calorimetry
(IC)
is
recommended,
but
not
always
available.
We
study
EE,
catabolism,
and
metabolic
stress
SAH,
TBI,
ICH,
sepsis
controls.
Methods:
A
prospective
observational
was
conducted
intensive
care
units
University
Medical
Center
Hamburg-Eppendorf,
Germany.
IC
used
measure
EE
on
days
2–3,
5–7,
10–15
post-admission.
Urinary
catecholamines,
metabolites,
urine
urea
were
also
measured.
Statistical
analysis
included
t-tests,
Chi-square
tests,
generalized
mixed
models.
Results:
110
patients—43
SAH
(13
surgical
securing
aneurysm
30
coil
embolization
aneurysm),
22
TBI
patients,
23
ICH
The
linear
model
for
groups
timepoints
including
age,
height,
weight
covariates
revealed
a
significantly
lower
at
timepoint
1
versus
SAH—interventional
(p
=
0.003)
control
0.004),
well
2
0.002)
SAH—surgical
0.013)
patients.
No
significant
differences
between
found
timepoints,
concerning
measurements
catecholamines
urine.
Conclusions:
In
no
meaningful
detected
compared
septic
critically
ill
except
early
phase.
Biology Direct,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 9, 2025
Despite
the
increasing
body
of
evidence
that
mitochondrial
activities
implicate
in
chronic
obstructive
pulmonary
disease
(COPD),
we
are
still
far
from
a
causal-logical
and
mechanistic
understanding
malfunctions
COPD
pathogenesis.
Differential
expression
genes
(DEGs)
six
publicly
available
bulk
human
lung
tissue
transcriptomic
datasets
patients
were
intersected
with
known
mitochondria-related
MitoCarta3.0
to
obtain
DEGs
associated
(MitoDEGs).
The
32
hub
MitoDEGs
identified
protein-protein
interaction
(PPI)
networks
demonstrated
superior
overall
diagnostic
efficacy
non-hub
MitoDEGs.
Random
forest
(RF)
analysis,
least
absolute
shrinkage
selection
operator
(LASSO)
regression,
Mendelian
Randomization
(MR)
analysis
further
nominated
NDUFS2,
CAT,
MRPL2
as
causal
for
COPD,
whose
predominate
expressions
macrophages
revealed
by
an
independent
single-cell
dataset
lungs.
Finally,
NDUFS2
was
evaluated
top-ranked
contributor
nomogram
model
its
downregulation
could
result
pro-inflammatory
secretion,
enhanced
intercellular
communications,
whereas
depressed
phagocytosis
gene
set
variation
(GSVA)
cell-cell
(CCI)
lungs,
which
later
confirmed
mouse
macrophage
cell
lines.
Our
study
established
linkage
between
providing
potential
therapeutic
avenue
alleviate
inflammation
accounting
targeting
genes.
canonical
component
electron
respiratory
chain,
highlighted
instrumental
susceptibility
risk-exposed
individuals
COPD.
Surgical Neurology International,
Journal Year:
2025,
Volume and Issue:
16, P. 23 - 23
Published: Jan. 24, 2025
Background:
Secondary
insults
such
as
brain
edema
is
commonly
observed
after
traumatic
injury
(TBI)
and
remains
an
important
cause
of
neurological
deterioration.
Based
on
the
corticosteroid
randomisation
significant
head
(CRASH)
trial
findings,
Brain
Trauma
Foundation
guidelines
recommend
against
giving
steroids
in
TBI.
However,
findings
two
recent
clinical
studies
suggest
that
there
may
be
a
subset
patients
who
benefit
from
steroids.
Methods:
This
study
was
retrospective,
single-center,
4-year
study.
The
analyzed
had
received
systemic
corticosteroids
for
pericontusional
delayed
time
interval
to
steroid
prescription,
drug
dosage,
symptomatic
improvement,
complications
were
analyzed.
Results:
There
19
males
eight
females.
Mean
age
42.1
years
(range,
21–91
years).
Except
one,
all
mild
TBI
categories.
All
contusions
computed
tomography.
Dexamethasone
used
tapering
doses
over
5–10
days,
starting
with
12
mg/day.
mean
prescription
trauma
5.9
median
duration
7
days.
All,
except
improvement.
complete
improvement
symptoms
2.8
no
pertinent
usage
any
our
cases.
Conclusion:
third
document
efficacy
cerebral
As
are
excellent
drugs
vasogenic
edema,
timing
dosage
factors
will
determine
their
We
strongly
feel
needs
more
robust
trials
good
patient
numbers
confirm
these
findings.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: June 24, 2024
Background
Etomidate
can
induce
myoclonus
with
an
incidence
of
50
~
85%
during
anesthesia
induction.
Dexamethasone,
as
a
long-acting
synthetic
glucocorticoid,
has
neuroprotective
effects.
However,
the
effects
dexamethasone
on
etomidate-induced
remain
uncertain.
Methods
Adult
male
Sprague–Dawley
rats
were
randomly
assigned
to
receive
etomidate
(1.5
mg/kg)
plus
(4
(etomidate
group)
or
same
volume
normal
saline
(NS)
NS
group).
The
mean
behavioral
scores,
local
field
potentials
and
muscular
tension
recorded
explore
myoclonus.
Liquid
chromatography
coupled
tandem
mass
spectrometric
system
(LC–MS/MS),
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR),
western
blotting
applied
analyze
levels
glutamate
γ
-aminobutyric
acid
(GABA),
mRNA
protein
expression
excitatory
amino
transporters
(EAATs),
plasma
corticosterone
at
different
time
points
after
anesthesia.
Results
Compared
treatment,
treatment
significantly
decreased
score
1,
3,
4,
5
min
administration;
peak
power
spectral
density
(PSD)
(
p
=
0.0197)
in
analysis
ripple
waves;
level
0.0139)
neocortex.
compared
NS,
increased
neocortical
proteins
EAAT1
0.0207)
EAAT2
0.0022)
aggravated
inhibition
4
h
0.0019),
0.0041),
6
0.0009)
administration.
Conclusion
Dexamethasone
attenuate
myoclonus,
inhibit
accumulation,
reverse
suppression
EAATs
neocortex
induced
by
following
while
conversely
aggravating
adrenal
suppression.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(40)
Published: Oct. 2, 2024
Unlike
mammals,
some
nonmammalian
species
recruit
Müller
glia
for
retinal
regeneration
after
injury.
Identifying
the
underlying
mechanisms
may
help
to
foresee
regenerative
medicine
strategies.
Using
a
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 18, 2024
Introduction
Natural
plants
are
valuable
resources
for
exploring
new
bioactive
compounds.
Artemisia
vulgaris
L.
is
a
traditional
Chinese
medicinal
herb
that
has
been
historically
used
treating
multiple
diseases.
Active
compounds
isolated
and
extracted
from
A.
typically
possess
immunomodulatory
anti-inflammatory
properties.
Artemvulactone
E
(AE)
sesquiterpene
lactone
with
unclear
biological
activities.
Methods
The
immunoregulatory
effects
of
AE
on
macrophages
were
assessed
by
ELISA,
RT-qPCR,
immunofluorescence,
western
blot
assay.
effect
lipopolysaccharide
(LPS)
-relates
signaling
pathways
was
examined
In
zebrafish
models,
the
larvae
yolk-microinjected
LPS
to
establish
inflammation
model
evaluated
determining
survival
rate,
heart
yolk
sac
edema
size,
neutrophils
infiltration
zebrafish.
interaction
between
Toll-like
receptor
4
(TLR4)
molecular
docking
dynamic
stimulation.
Results
reduced
expression
secretion
pro-inflammatory
cytokines
(TNF-α
IL-6),
inflammatory
mediators
iNOS
COX-2,
as
well
decreases
production
intracellular
NO
ROS
in
LPS-stimulated
macrophages.
addition,
exerted
its
synergistically
inhibiting
MAPK/JAK/STAT3-NF-κB
pathways.
Furthermore,
enhanced
rate
attenuated
response
embryos
treated
LPS.
Finally,
dynamics
results
indicate
forms
stable
complexes
TLR4
through
Ser127
residue,
thus
completely
impairing
subsequent
activation
MAPK-NF-κB
signaling.
Conclusion
exhibits
notable
activity
represents
potential
agent
inflammation-associated
