Sinomenine attenuates uremia vascular calcification by miR-143-5p

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

Abstract Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There no approved therapeutic strategy for prevention vascular calcification. Sinomenine exhibited anti-inflammatory immunosuppressive effects. Objective this study was investigate effect sinomenine in its potential molecular mechanism. Adenine-induced uremic rats were constructed administrated with sinomenine. Optical clearing aortas, alizarin red staining, von Kossa quantification, micro-CT analyses performed analyze aortas. Administration 40 mg/kg/d effectively alleviated rats. The miRNA sequencing revealed differentially expressed miRNAs aortas bioinformatic analysis assisted screening. We screened 9 differential their predicted target genes. By qRT-PCR, we validated that expression rno-miR-143-5p corresponding our prediction. inhibited smooth muscle cells (VSMCs) calcification, accompanied miR-143-5p upregulation. MiR-143-5p mimic decreased VSMCs high phosphate condition. On contrary, inhibitor increased condition, which by In chronic kidney disease patients level circulating lower than those without significantly rat. one collection modified Reduction not only concomitant phenomenon pro-calcification condition but also contribute Circulating supposed biomarker patients. conclusion, attributed regulation partly.

Language: Английский

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Trans 10, cis 12-conjugated linoleic acid alleviates vascular fibrosis in obese mice

Prostaglandins Leukotrienes and Essential Fatty Acids, Journal Year: 2025, Volume and Issue: 204, P. 102669 - 102669

Published: Feb. 21, 2025

Language: Английский

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Bexarotene regulates zebrafish embryonic development by activating Wnt signaling pathway

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123664 - 123664

Published: April 1, 2025

Language: Английский

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Causal relationship between circulating inflammatory proteins and atherosclerosis: a bidirectional Mendelian randomization study and meta-analysis

Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Oxidative Stress and Inflammation in Myocardial Ischemia–Reperfusion Injury: Protective Effects of Plant‐Derived Natural Active Compounds

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

ABSTRACT Acute myocardial infarction (AMI) remains a leading cause of death among patients with cardiovascular diseases. Percutaneous coronary intervention (PCI) has been the preferred clinical treatment for AMI due to its safety and efficiency. However, research indicates that rapid restoration oxygen supply following PCI can lead secondary injury, termed ischemia–reperfusion injury (MIRI), posing grave threat patient survival. Despite ongoing efforts, mechanisms underlying MIRI are not yet fully elucidated. Among them, oxidative stress inflammation stand out as critical pathophysiological mechanisms, playing significant roles in MIRI. Natural compounds have shown strong therapeutic potential their high efficacy, availability, low side effects. Many current studies indicate natural mitigate by reducing inflammatory responses. Therefore, this paper reviews during role intervening these processes, aiming provide basis reference future development drugs treating

Language: Английский

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Understanding and Mitigating Adverse Biological Responses Resulting from β-Casomorphin-7: Strategies, Challenges, and Future Directions – A Review

International Dairy Journal, Journal Year: 2024, Volume and Issue: unknown, P. 106166 - 106166

Published: Dec. 1, 2024

Language: Английский

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