Targeted therapeutic strategy for oral squamous carcinoma using celecoxib-loaded GABA/wheat gluten-alginate nanocarrier hydrogel with glutathione down-regulation and enhanced CCND2-mediated apoptosis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140679 - 140679

Published: Feb. 1, 2025

Language: Английский

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The future of pharmaceuticals: Artificial intelligence in drug discovery and development

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101248 - 101248

Published: Feb. 1, 2025

Language: Английский

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Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107332 - 107332

Published: July 30, 2024

The endoplasmic reticulum (ER) plays a pivotal role in protein folding and secretion, Ca

Language: Английский

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Direct Inhibition of Macrophage STING Signaling by Curcumol Protects Against Myocardial Infarction via Attenuating the Inflammatory Response

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156403 - 156403

Published: Jan. 18, 2025

Language: Английский

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Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141866 - 141866

Published: March 1, 2025

Language: Английский

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Natural products targeting ferroptosis in depression: Research progress and therapeutic prospects

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156818 - 156818

Published: April 28, 2025

Language: Английский

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Enhanced Detection of Curcumol in Biological Samples via Acetonitrile‐Anhydrous Sodium Sulfate Salt‐Assisted Liquid‐Liquid Microextraction Coupled With High‐Performance Liquid Chromatography

Separation Science Plus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

ABSTRACT Curcumol, a significant bioactive molecule, requires accurate detection methods due to its extensive pharmacological properties. This study develops high‐performance liquid chromatography (HPLC) detect curcumol and constructs sample pretreatment techniques using salt‐assisted liquid‐liquid microextraction (SALLME). The optimization process focuses on conditions for acetonitrile (ACN) anhydrous sodium sulfate‐assisted microextraction. By adding excess sulfate an ACN aqueous solution, precipitates, forming saturated saline solution resulting in two‐phase system. being highly soluble ACN, separates into enriches within the phase, achieving effective matrix separation. SALLME demonstrated enrichment factor of up 12.4 curcumol. extracted is then injected HPLC instrument quantitative analysis. method exhibited good linear range (0.5–10.0 µg/mL) low limit (0.05 µg/mL). results indicate that can be effectively separated from complex matrices this technique. optimizing salt concentration temperature, determining biological samples was successfully established, recoveries between 86.2% 137.6% spiked urine blood samples. Furthermore, offers rapid, efficient, environmentally friendly preparation, promising applications clinical settings.

Language: Английский

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Fungicidal activity of curcumol against Phytophthora capsici via inhibiting phosphatidylcholine biosynthesis and its systemic translocation in plants

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 207, P. 106214 - 106214

Published: Nov. 17, 2024

Language: Английский

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Micellar curcumol for maintenance therapy of ovarian cancer by activating the FOXO3a

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2024, Volume and Issue: 62, P. 102789 - 102789

Published: Oct. 1, 2024

Language: Английский

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