Sepsis-induced cardiac dysfunction: mitochondria and energy metabolism

Intensive Care Medicine Experimental, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 18, 2025

Abstract Sepsis is a life-threatening multi-organ dysfunction syndrome caused by dysregulated host response to infection, posing significant global healthcare challenge. Sepsis-induced myocardial (SIMD) common complication of sepsis, significantly increasing mortality due its high energy demands and low compensatory reserves. The substantial mitochondrial damage rather than cell apoptosis in SIMD suggests disrupted cardiac metabolism as crucial pathophysiological mechanism. Therefore, we systematically reviewed the mechanisms underlying SIMD, including alterations substrates, excitation–contraction coupling processes, dysfunction, autophagy biogenesis, summarizing potential therapeutic targets within them.

Language: Английский

The role of deacetylase SIRT1 in allergic diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

The silent information regulator sirtuin 1 (SIRT1) protein is an NAD

Language: Английский