Inhibition of IRF3-STING axis interaction in silicosis using natural compounds: an in-silico study using molecular docking, ADMET, molecular dynamics and MMPBSA approach DOI

Ashita Sood,

Mahesh Kulharia

In Silico Pharmacology, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 9, 2024

Language: Английский

Exploration of Mechanism of Bufalin and Bufalin Derivatives in Hepatocellular Carcinoma DOI

Xinchen Gao,

Tong-hua Bian,

Xinyu Wei

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156686 - 156686

Published: March 1, 2025

Language: Английский

Citations

0
A second act for spironolactone: cognitive benefits in renal dysfunction – a critical review DOI
Akhil Sharma, Ashi Mannan,

Shareen Singh

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(5)

Published: April 29, 2025

Language: Английский

Citations

0
Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract DOI Creative Commons
Huiling Zhang, Junrong Luo, Qing Wan

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Extraction is the core process for obtaining bioactive compounds from medicinal plants. Enhancing extraction efficiency of aromatic herbs has become a critical challenge. This study introduced novel freeze-pressure regulated (FE) technique to improve Gui Zhi (GZ). Compared traditional methods, FE yielded significantly lower pH 4.74, higher zeta potential −13.93 mV, and smaller average particle size 304.57 nm. Scanning electron microscopy (SEM) mercury intrusion porosimetry (MIP) confirmed that creates larger pores an expanded surface area, facilitating more effective compound release. HPLC analysis indicated increased cinnamaldehyde content 348.53 370.20 μg/g. UPLC-MS further demonstrated extracting volatile phenolic compounds. Furthermore, therapeutic effect GZ extract on wind-cold syndrome model was investigated. alleviated symptoms restored lung tissue integrity, through regulation citric acid cycle thiamine metabolism pathways. The findings not only support application technology in herbal but also offer approaches efficient utilization like modern medicine.

Language: Английский

Citations

0
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway DOI Creative Commons
Chang Li,

Zhen Ma,

Xiang Wei

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to investigate the and mechanisms of bufalin myocardial I/R injury. In vivo, ameliorated injury, characteristics with better ejection function, decreased infarct size less apoptosis. The levels pyroptotic proteins were increased in I/R-treated macrophages inflammatory cytokines expressed more I/R-induced mouse, could be attenuated by bufalin. Bufalin also reduced H/R-treated macrophage pyroptosis vitro. Autophagic flux blockage ROS accumulation impaired macrophages. Overexpression p62 abrogated anti-proptosis anti-oxidative apoptosis related changed TUNEL-positive ratio was raised cardiomyocytes that received conditioned medium treatment macrophages, while pretreatment reduce These findings indicate may attenuate injury suppressing via P62 pathway.

Language: Английский

Citations

1
Inhibition of IRF3-STING axis interaction in silicosis using natural compounds: an in-silico study using molecular docking, ADMET, molecular dynamics and MMPBSA approach DOI

Ashita Sood,

Mahesh Kulharia

In Silico Pharmacology, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 9, 2024

Language: Английский

Citations

0