Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103557 - 103557

Published: Feb. 18, 2025

Ruminal dysbiosis-induced liver injury is prevalent in dairy cows, yet its underlying mechanisms remain incompletely understood. Ferroptosis, a newly identified form of programmed cell death distinct from apoptosis and necrosis, has been implicated various diseases by emerging studies. In the present study, lipopolysaccharide (LPS) γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) were employed to establish vitro vivo models using bovine hepatocytes mice, respectively. It was observed that noncytotoxic iE-DAP alone did not influence lipid peroxidation or GPX4, but exacerbated LPS-induced ferroptosis hepatocyte injury. Notably, co-treatment with LPS (LPS/iE-DAP)-induced mitigated intervention inhibitor ferrostatin-1 (Fer-1). Mechanistically, activated IL-6/STAT3 signaling pathway found mediate LPS/iE-DAP-induced ferroptosis. Suppression IL-6/STAT3, either through IL6 STAT3 knockdown pharmacological intervention, reduced Fe2+ accumulation alleviated ferroptotic death. Further investigations enhanced ferritinophagy impaired iron export. Either disrupting knocking down NCOA4 restoring export via HAMP relieved intracellular overload inhibited Specifically, LPS/iE-DAP treatment increased interaction between hepcidin ferroportin, promoting ferroportin ubiquitination degradation, thereby blocking efflux. Furthermore, we provided several evidence prove quercetin pretreatment decreasing hepatic targeting vivo, effects reversed addition recombinant IL-6. Based on these findings, concluded triggering regulating IL-6/STAT3/ferritinophagy-dependent release IL-6/STAT3/hepcidin/ferroportin-dependent export, while could alleviate this inhibiting pathway. This study provides novel insights into whereby ruminal dysbiosis induces presents prospective solution for

Language: Английский

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Research progress on quercetin in improving the survival rate of random skin flap

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 16, 2025

Language: Английский

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Unfolded protein response: An essential element of intestinal homeostasis and a potential therapeutic target for inflammatory bowel disease

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 17, 2025

Abstract Different physiological and pathological situations can produce alterations in the cell's endoplasmic reticulum (ER), leading to a condition known as ER stress, which trigger an intricate intracellular signal transduction system unfolded protein response (UPR). UPR is primarily tailored restore proteostasis equilibrium; otherwise, if stress persists, it cause programmed cell death cytoprotective mechanism drive inflammatory processes. Therefore, since intestinal cells strongly rely on for their biological functions unbalanced has been linked inflammatory, metabolic, immune disorders, here we discussed role of within tract, focusing contribution bowel disease development. Importantly, also highlighted promising potential components therapeutic targets diseases.

Language: Английский

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Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Language: Английский

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Naematelia aurantialba: a comprehensive review of its medicinal, nutritional, and cultivation aspects

Food & medicine homology., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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