Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4/PI3K/AKT/NF-κB signal pathways
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119787 - 119787
Published: April 1, 2025
Language: Английский
Protective Potential of Morin in Ifosfamide-Induced Lung Toxicity: Modulation of Oxidative Stress, Inflammation and Apoptosis Parameters
Veterinary Sciences and Practices,
Journal Year:
2025,
Volume and Issue:
20(1), P. 50 - 56
Published: April 29, 2025
In
this
study,
the
protective
effect
of
morin
against
lung
toxicity
induced
by
ifosfamide
(IFO),
a
widely
used
drug
in
cancer
treatment,
was
investigated.
Thirty-five
male
Sprague
Dawley
rats
were
divided
into
five
groups:
Control,
Morin
(200
mg/kg),
IFO
and
two
different
doses
(IFO
+
100
mg/kg
200
mg/kg).
Rats
given
or
for
2
days
on
second
day,
500
administered
as
single
dose.
Biochemical
molecular
methods
analyzed
oxidative
stress,
inflammation,
autophagy
apoptosis
markers.
According
to
data
obtained,
increased
malondialdehyde
(MDA)
levels
tissue,
while
decreasing
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPX)
activities
(GSH)
levels.
However,
it
observed
that
administration
decreased
MDA
GSH
GPx,
SOD,
CAT
activities.
inhibited
expression
B-cell
lymphoma-2
(Bcl-2)
nuclear
factor
erythroid
2-related
(Nrf-2)
/heme
oxygenase-1
(HO-1)
pathway,
increasing
factor-kappa
B
(NF-κB),
inducible
nitric
oxide
synthase
(iNOS),
Bcl-2-associated
x
protein
(Bax),
cysteine
aspartate
specific
protease-3
(Caspase-3).
NF-κB
iNOS
inflammation
activating
Nrf-2/HO-1
pathway
prevented
Bax
Caspase-3
Bcl-2.
It
also
caused
decrease
Beclin-1
findings,
affecting
various
signaling
pathways
causing
cellular
damage,
demonstrated
qualities
damage.
Language: Английский
Perillaldehyde protect chondrocytes from mitophagy-associated apoptosis and NLRP3-mediated inflammation by regulating ALOX5/NF-kB signaling in osteoarthritis
Q. Zhou,
No information about this author
Xun Li,
No information about this author
Dong Hou
No information about this author
et al.
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
158, P. 114820 - 114820
Published: May 15, 2025
Language: Английский
Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling
Apiwan Arinno,
No information about this author
Pichayapa Sukmak,
No information about this author
Purisha Kulworasreth
No information about this author
et al.
Current Research in Pharmacology and Drug Discovery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100223 - 100223
Published: May 1, 2025
Language: Английский