Bibliometric and Graphical Analysis of Ferroptosis and Aging Research: Trends, Gaps, and Future Directions

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155949 - 155949

Published: March 1, 2025

Language: Английский

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Unveiling the role of Na⁺/K⁺-ATPase pump: neurodegenerative mechanisms and therapeutic horizons

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 8, 2025

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the death of dopaminergic neurons and aggregation alpha-synuclein (α-Syn). It presents with prominent motor symptoms, time diagnosis, significant number have already been lost. Current medications can only alleviate symptoms but cannot halt progression. Studies confirmed that both neuronal loss α-Syn are associated necroptosis mechanisms. Necroptosis, regulated form cell death, has recognized as an underexplored hotspot in PD pathogenesis research. In this review, we propose spatiotemporal model progression, highlighting interactions between aggregation, mitochondrial dysfunction, oxidative stress, neuroinflammation necroptosis. These processes not drive also contribute to early non-motor offering insights into potential diagnostic markers. Finally, touch upon therapeutic inhibition enhancing current treatments, such L-Dopa. This review aims provide new perspective on identify avenues for development more effective strategies.

Language: Английский

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Unraveling cell death mechanisms in traumatic brain injury: dynamic roles of ferroptosis and necroptosis

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 10, 2025

Language: Английский

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