Neurological Research, Journal Year: 2024, Volume and Issue: 46(6), P. 487 - 494
Published: April 11, 2024
A novel research objective is to identify new molecules in more readily accessible biological fluids that could be used the diagnosis of multiple sclerosis (MS) and other demyelinating disorders.
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 422 - 422
Published: March 29, 2024
Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It characterized by loss of tear film homeostasis and accompanied symptoms that may potentially result in damage to surface even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, ethanol consumption. As its prevalence continues rise, has garnered considerable attention, prompting exploration potential new therapeutic targets. Recent studies have found when production ROS exceeds capacity antioxidant defense system on surface, oxidative stress ensues, leading cellular apoptosis further damage. These events can exacerbate inflammation responses, increasing levels promoting vicious cycle DED. Therefore, given central role reactive oxygen species DED, strategies involving antioxidants emerged novel approach treatment. This review aims enhance our understanding intricate relationship between thereby providing directions explore innovative approaches this complex disorder.
Language: Английский
Citations
22
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 318 - 328
Published: March 4, 2024
Language: Английский
Citations
16
BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 154, P. 03011 - 03011
Published: Jan. 1, 2025
Sambiloto ( Andrographis paniculata ) contains andrographolide compounds, which have anti-inflammatory properties. On the other hand, catfish oil Pangasius micronema Blkr.) DHA and EPA compounds known to be unsaturated fatty acids antiinflammatory extracts will combined determine pharmacological effects caused by an acute toxicity test LD 50 value of combination extracts. This research is conducted experimentally, utilizing mice as animals. The extract was administered for 14 days, symptoms were observed, including number animals that died, body weight, weight liver, kidneys, heart. data then tested using Thompson-Weil method statistical tests oneway ANOVA continued with Tukey post hoc test. results indicated at highest dose, but extracts’ pseudo-LD50, implying could theoretically still receive dose value. analysis revealed no significant differences in organ mice, indicating this use two up dose.
Language: Английский
Citations
1
Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(2), P. 51 - 51
Published: Feb. 20, 2025
As a consequence of the natural aging process, lacrimal glands may become dysfunctional. The present study aimed to investigate potential role melatonin (MLT) in alleviation age-related gland dysfunction and elucidate underlying mechanism. In this study, 2-month-old, 18-month-old, MLT intraperitoneally injected 18-month-old mice were obtained for immunofluorescence, immunohistochemistry experiments, Western blotting detect inflammatory factors AQP5 expression, electron microscopy mitochondrial structure dense granules. Lacrimal from taken cell culture, PCR performed signaling pathways which acts. addition, human explant cultures validate SIRT-1/NLRP3 pathways. we discovered that increased response, decreased secretory function, led dysregulation gland. Compared with 2-month-old mice, SIRT-1/3/6 gene transcript levels significantly mice. reduced (IL-1β, IL-6, TNF-α) expression via pathway aged mouse. Furthermore, restored granules mouse explants gland, relieved fibrosis. demonstrated alleviates humans pathway. alleviated response decline function
Language: Английский
Citations
0
Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 460 - 460
Published: March 6, 2025
Dry eye disease (DED), also known as keratoconjunctivitis sicca, is a multifactorial ocular characterized by tear film insufficiency due to diverse etiologies including aging, incomplete and infrequent blinking, hormonal changes, medications, systemic diseases. Classified into aqueous-deficient dry (ADDE), evaporative (EDE), mixed subtypes, DED presents with symptoms such irritation, stinging, redness, foreign body sensation, sensitivity light, blurred or fluctuating vision. While rare, severe cases may lead vision loss. With its rising global prevalence across age groups, poses significant public health challenge. Primary care physicians (PCPs), often the first point of contact for patients, require timely screening management strategies. This review explores epidemiology, pathophysiology, clinical manifestations, diagnosis, DED, emphasizing practical approaches PCPs. narrative was conducted searching MEDLINE, PubMed, Google Scholar databases relevant articles. Diagnostic approaches, detailed history taking, patient-reported questionnaires, differential assessments are discussed alongside strategies, symptomatic ophthalmic treatment, risk factor mitigation (e.g., reduced digital device screen time), prevention, nutrition. By providing synopsis early that PCPs encounter, managing in primary setting, guidelines on when refer specialty care, this comprehensive aims equip knowledge improve optimize patient outcomes.
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110346 - 110346
Published: March 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 8, 2025
Rising incidences of dry eye, often attributed to modern lifestyle and environmental factors, highlight the need for knowledge, attitudes, practices (KAP) studies inform tailored interventions. This study evaluated patients' KAP concerning lifestyle-related eye at Ophthalmology Hospital China Academy Chinese Medical Sciences from July 1 26, 2024. A self-designed questionnaire was used gather demographic data assess scores, yielding 556 valid responses (98.93%). Among participants, 342 (61.51%) were female, with a mean age 39.26 ± 13.56 years. Mean scores 7.44 4.65 (knowledge), 35.20 4.10 (attitude), 35.77 6.15 (practice). Mediation analysis indicated direct influences familial history on knowledge impacting attitude, various factors influencing practice. While patients exhibited limited they generally held positive attitudes engaged in proactive practices. Enhancing patient education related is essential boost foster effective prevention management strategies.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 931 - 931
Published: April 10, 2025
Background/Objectives: A probiotic Streptococcus thermophilus (iHA318) has been demonstrated to alleviate dry eye symptoms in a mouse model. This study investigated its effects on mitigation clinical trial. Methods: total of 68 volunteers were recruited the double-blind trial and randomly divided into group placebo group. The received iHA318 capsules daily for 35 days via oral intake, while microcrystalline cellulose capsules. Assessments before after intervention performed tear volume (TV), break-up time (TBUT), osmolarity (Osmo), serum sialic acid (SA) concentrations, Ocular Surface Disease Index (OSDI), an impression cytology analysis was conducted immunofluorescence detection NLRP3 expression. Results: significantly increased group, although effect observed showed significant reduction osmolarity, extended TBUT, improved OSDI score. These parameters also without statistical significance. In addition, SA contrast slight non-significant increase Reductions inflammasome activation found only Conclusions: conclusion, improvement major treatment compared
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3833 - 3833
Published: April 18, 2025
Sexual dimorphism significantly impacts the lacrimal gland’s structure, function, and ageing processes, playing an important role in dry eye disease (DED) pathophysiology. This multifactorial disorder, characterised by tear film instability, inflammation, visual impairment, disproportionately affects women, especially after menopause. It highlights interplay between sex steroid hormones, gland environmental factors. Systemic local androgens are vital for maintaining health production, while of oestrogens remains less clear. Evidence suggests dose context-dependent effects on inflammation glandular function. Histopathological molecular studies reveal significant differences gland, with women exhibiting more pronounced age-related degenerative changes, including fibrosis acinar atrophy, contributing to their increased susceptibility DED. Despite these findings, underlying mechanisms connecting receptor expression, tissue regulation disparities remain poorly understood, highlighting need further research. review synthesises current knowledge sex-specific emphasising importance integrating systemic biomarkers, histological data, insights into personalised therapeutic strategies. By tailoring treatments patients’ unique hormonal profiles, medicine has potential transform DED management, addressing unmet clinical needs improving outcomes.
Language: Английский
Citations
0
Therapeutic Advances in Ophthalmology, Journal Year: 2025, Volume and Issue: 17
Published: May 1, 2025
Background: Dry eye disease is a common condition that causes symptoms such as dryness, irritation, and blurry vision. The pathophysiology of dry features both aqueous deficiency (loss tear production) increased evaporation the lipid layer), with latter mechanism responsible for most presentation. Ocular surface (OSD) prevalent condition, often linked to meibomian gland dysfunction (MGD), characterized by film instability like dryness irritation. Thermal pulsation therapy, an FDA-approved treatment MGD, uses heat pressure restore function, improving stability ocular health. Studies show its benefits last up year, enhancing Surface Disease Index (OSDI), break-up time (TBUT), Meibomian Glands Yielding Secretion Score (MGYSS) scores. This systematic review evaluates LipiFlow compared placebo, warm compresses, other devices, focusing on safety, efficacy, impact recovery long-term outcomes. Methods: A comprehensive search was performed across PubMed, MEDLINE, Embase, Scopus until December 2024. Only randomized controlled trials (RCTs) evaluating were included. primary outcomes assessed OSDI TBUT, secondary including expression scores, corneal fluorescein staining (CFS), MGYSS, layer thickness (LLT). Meta-analyses conducted using random-effects model, heterogeneity I ² statistics. Results: Thirteen studies reported (Std diff −0.076, 95% CI −0.277 0.125, p = 0.255, 71.21%). Twelve evaluated showing significant improvement 0.449, 0.173–0.725, 0.001, 78.49%). TBUT results from twelve not statistically 0.211, −0.017 0.440, 0.8350, 0%). CFS showed in six −0.130, −0.248 −0.012, 0.031, LLT changes insignificant −0.071, −0.381 0.239, 0.653, Conclusion: effectively improves indicated CFS, but significant. therapy beneficial patients severe baseline MGD. Further research needed establish patient-specific
Language: Английский
Citations
0