O-GlcNAcylation dictates pyroptosis DOI Creative Commons
Yue Lang, Jincheng Li, Leiliang Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating signaling pathways pyroptosis. Specifically, GSDMD linked modulation pyroptosis, suggesting that enhancing could be crucial for improving hypoperfusion sepsis. Additionally, GSDME, another member gasdermin family, facilitates macrophage pyroptosis through induced by high glucose levels context periodontitis. The also examines effects on NLRP3 inflammasome regulators, including NEK7 NF-κB. Overall, this pathogenesis conditions such as sepsis, periodontitis, osteoarthritis, identifying potential therapeutic targets managing inflammatory responses targeted modulation.

Language: Английский

The role of pyroptosis in hepatocellular carcinoma DOI

Zhimiao Zou,

Minghui Zhao, Yang Yang

et al.

Cellular Oncology, Journal Year: 2023, Volume and Issue: 46(4), P. 811 - 823

Published: March 2, 2023

Language: Английский

Citations

29
The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (NAFLD) DOI Creative Commons
Shujing Li,

An-Bu Liu,

Yuanyuan Yu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 3, 2024

Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome characterized by the excessive accumulation of fat within cells, which can progress to end-stage in severe cases, posing threat life. Pyroptosis distinct, pro-inflammatory form cell death, differing from traditional apoptosis. In recent years, there has been growing research interest association between pyroptosis and NAFLD, encompassing mechanisms functions progression as well potential therapeutic targets. Controlled activate immune eliciting host responses shield body harm. However, undue activation may worsen inflammatory responses, induce cellular or tissue damage, disrupt potentially impact function. This review elucidates involvement key molecular players, including NOD-like receptor thermal protein domain associated 3(NLRP3) inflammasome, gasdermin D (GSDMD), caspase family, pathogenesis NAFLD. It emphasizes promising prospects targeting approach for NAFLD offers valuable insights into future directions field treatment.

Language: Английский

Citations

4
Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy DOI Creative Commons
Tao Wei, Yang Qin,

Xiaohui Lin

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 10, 2025

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, exerts substantial burden on healthcare systems globally. Emerging evidence highlights ferroptosis - an iron-dependent form cell death driven by lipid peroxidation and glutathione depletion as critical contributor to DN progression via oxidative stress, tubular injury, glomerular dysfunction. Despite increasing research interest, comprehensive synthesis trends mechanistic insights is lacking. This study integrated bibliometric analysis with review map the evolving landscape in DN, identify hotspots, propose future directions for therapeutic development. In total, 86 publications (2018-2023) were retrieved from Web Science Core Collection analyzed using CiteSpace VOSviewer. Co-occurrence networks, citation trends, keyword bursts examined delineate global contributions, collaborative emerging themes. Annual publication numbers surged 12-fold after 2020, China contributing highest proportion (60.4%), led institutions such Zhengzhou University. The United States America Germany showed high centrality networks. Key themes included peroxidase 4 (GPX4)-mediated antioxidant defenses, acyl-CoA synthetase long-chain family member (ACSL4)-mediated remodeling, iron dysregulation. Frontiers Endocrinology (nine articles) Free Radical Biology Medicine (highest count: 171) emerged pivotal platforms. Mechanistic analyses identified three defense axes (GPX4, FSP1/CoQ10, GCH1/BH4) type-specific vulnerabilities tubular, podocyte, endothelial cells. Preclinical agents, including ginkgolide B (GB) dapagliflozin, effectively restored homeostasis attenuated damage. Ferroptosis promising target yet its clinical translation remains infancy. Future efforts should prioritize large-scale trials, single-cell profiling, interdisciplinary integration bridge molecular precision therapies. provides roadmap advancing ferroptosis-targeted interventions emphasizing collaborations biomarker-driven strategies.

Language: Английский

Citations

0
New Insights into Melatonin’s Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of Cyprinus carpio: Implicating Mitochondrial Metabolic Imbalance and mtROS/cGAS-STING/NF-κB Axis DOI
Lei Diao, Yang Ma,

Liping Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Thiacloprid (THI) is a synthetic insecticide, the misuse targeted chiefly to control aphid pest species in orchards and vegetables. Melatonin (MET) hormone that plays crucial physiological roles anti-inflammatory capacities of fish. We explored function MET (100 μM) mitigate toxicity induced by THI (20 lymphocytes. Our results indicate led notable rise lymphocyte mortality. Lymphocytes exposed exhibited heightened incidence pyroptosis, accompanied upregulation expression associated with pyroptosis (NLRP3, GSDMEA, IL-18). Meanwhile, exposure decrease mitochondrial membrane potential, an increase mtROS levels, reduction intracellular ATP, DNA, NADPH/NADP+ indicating imbalance metabolism within Additionally, these effects were reversed treatment, where MitoQ treatment showed suppression reduced caused via mtROS/cGAS-STING/NF-κB axis. Importantly, provided defense against immunotoxic impacts ameliorating enhancing capability research potentiates safeguarding cultured fish from biological hazards highlights valuable application common carp.

Language: Английский

Citations

0
The role of inflammatory response and metabolic reprogramming in sepsis-associated acute kidney injury: mechanistic insights and therapeutic potential DOI Creative Commons

An-Bu Liu,

Bin Tan,

Ping Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

Sepsis represents a severe condition characterized by organ dysfunction resulting from dysregulated host response to infection. Among the organs affected, kidneys are particularly vulnerable, with significant functional impairment that markedly elevates mortality rates. Previous researches have highlighted both inflammatory dysregulation and metabolic reprogramming crucial in onset progression of sepsis associated acute kidney injury (SA-AKI), making these processes potential targets for innovative therapies. This study aims elucidate pathophysiological mechanisms renal perspective dysregulation, particular emphasis on pyroptosis, necroptosis, autophagy, ferroptosis. Furthermore, it will incorporate insights into provide detailed analysis driving SA-AKI explore targeted therapeutic strategies, providing solid theoretical framework development therapies SA-AKI.

Language: Английский

Citations

3
Mustard gas exposure instigates retinal Müller cell gliosis DOI Creative Commons
Binapani Mahaling, Nishant R. Sinha,

Sibabalo Sokupa

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 230, P. 109461 - 109461

Published: April 5, 2023

Language: Английский

Citations

6
β-Asarone Alleviates High-Glucose-Induced Oxidative Damage via Inhibition of ROS Generation and Inactivation of the NF-κB/NLRP3 Inflammasome Pathway in Human Retinal Pigment Epithelial Cells DOI Creative Commons
Cheol Park, Hee‐Jae Cha, Hyun Hwangbo

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1410 - 1410

Published: July 11, 2023

Diabetic retinopathy (DR) is the leading cause of vision loss and a major complication diabetes. Hyperglycemia-induced accumulation reactive oxygen species (ROS) an important risk factor for DR. β-asarone, component volatile oil extracted from Acori graminei Rhizoma, exerts antioxidant effects; however, its efficacy in DR remains unknown. In this study, we investigated whether β-asarone inhibits high-glucose (HG)-induced oxidative damage human retinal pigment epithelial (RPE) ARPE-19 cells. We found that significantly alleviated cytotoxicity, apoptosis, DNA HG-treated cells via scavenging ROS generation. β-Asarone also attenuated excessive lactate dehydrogenase mitochondrial by increasing manganese superoxide dismutase glutathione activities. HG conditions markedly increased release interleukin (IL)-1β IL-18 upregulated their protein expression activation nuclear factor-kappa B (NF-κB) signaling pathway, whereas reversed these effects. Moreover, levels NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome multiprotein complex molecules, including thioredoxin-interacting protein, NLRP3, apoptosis-associated speck-like containing caspase-recruitment domain, cysteinyl aspartate-specific proteinase-1, were under conditions. However, remained similar to those control group presence β-asarone. Therefore, protects RPE HG-induced injury blocking generation NF-κB/NLRP3 activation, indicating potential as therapeutic agent treatment.

Language: Английский

Citations

6
Reduction of high glucose-induced oxidative injury in human retinal pigment epithelial cells by sarsasapogenin through inhibition of ROS generation and inactivation of NF-κB/NLRP3 inflammasome pathway DOI
Yung Hyun Choi

Genes & Genomics, Journal Year: 2023, Volume and Issue: 45(9), P. 1153 - 1163

Published: June 24, 2023

Language: Английский

Citations

5
Mapping the current trends of autophagy in retinal diseases: A bibliometric analysis DOI Creative Commons
Chengzhi Liu, Xiaonan Li,

Laraib Imdad

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32050 - e32050

Published: May 29, 2024

Several scholarly publications have thoroughly examined the significant role of autophagy in pathogenesis, progression, and treatment retinal diseases. This research utilized bibliometric analysis to identify primary areas focus emerging trends within discipline offer a comprehensive summary.

Language: Английский

Citations

1
Bibliometric and visual analysis of diabetes mellitus and pyroptosis from 2011 to 2022 DOI Creative Commons
Xiaodong Li, Xiaojuan Su,

Fenglin Xia

et al.

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: July 13, 2023

To visualize and analyze the published literature on diabetes mellitus pyroptosis based a bibliometric approach, so as to provide comprehensive picture of hot research directions dynamic progress in this field.This study was web science core collection database conduct search field Pyroptosis from January 1985 August 2022, including field, well visual analysis number citations, year publication, journal, author, institution, country, topic.A total 139 related cellular scorch 2011 2022 were retrieved, with 3009 citations maximum 255 for single article, which had first author Schmid-Burgk, JL The article is Germany; among 20 publishing countries, China leads 100 articles; 222 institutions, Harbin Medical University 18 articles 184 citations; 980 authors, Chen, X tops list high-impact authors 5 29 citations. Among 98 journals, "CELL DEATH DISEASE" ranked both volume journals 4 349 keywords, "pyroptosis" cumulative frequency 65 times. cluster divided into three categories, chronic complications (67 articles), (60 combined other diseases (12 its increased rapidly 2019, which, diabetic cardiomyopathy (27 articles) highest articles.Based achieved studies significant outstanding contributions thus framing showing development changes field. At same time, provides information direction clinicians investigators pyroptosis-related future.

Language: Английский

Citations

2