Trend Research of Diabetes and Pyroptosis: Bibliometric Analysis and Literature Review

Published: Jan. 5, 2023

Objective: To visualize and analyze the published literature on diabetes pyroptosis based a bibliometric approach, so as to provide comprehensive picture of hot research directions dynamic progress in this field. Methods: This study was web science core collection database conduct search field Pyroptosis from January 1985 August 2022, including field, well visual analysis number citations, year publication, journal, author, institution, country, topic. Results: A total 139 related cellular scorch 2011 2022 were retrieved, with 3009 citations maximum 255 for single article, which had first authorSchmid-Burgk, JL The author article is Germany; among 20 publishing countries, China leads 100 articles; 222 institutions, Harbin Medical University 18 articles 184 citations; 980 authors, Chen, X tops list high-impact authors 5 29 Among 98 journals, "CELL DEATH DISEASE" ranked both volume high impact journals 4 349 keywords, "pyroptosis" cumulative frequency 65 times. cluster divided into three categories, chronic complications (67 articles), (60 combined other diseases (12 its increased rapidly 2019, which, diabetic cardiomyopathy (27 articles) highest articles. Conclusions: Based 2011-2022, achieved studies significant outstanding contributions thus framing showing development changes At same time, provides information direction clinicians investigators future.

Language: Английский

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Chrysophanol ameliorates oxidative stress and pyroptosis in mice with diabetic nephropathy through the Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling pathway

Acta Biochimica Polonica, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 29, 2023

Diabetic nephropathy (DN), a microvascular complication of diabetes, increases the risk all-cause diabetes and cardiovascular mortalities. Moreover, oxidative stress pyroptosis play important roles in pathogenesis DN. Rhubarb is widely used traditional medicine, chrysophanol (Chr), free anthraquinone compound abundant rhubarb, exhibits potent antioxidant properties ameliorates renal fibrosis. Therefore, this study aimed to investigate effects Chr on injury, stress, mice with A DN model was established by feeding high-sugar fat diet injecting them 50 mg/kg streptozotocin as positive control. The had significantly impaired function, thickened glomerular thylakoids basement membranes, increased fibrous tissue, inflammatory cell infiltration. Superoxide dismutase (SOD) levels were reduced, malondialdehyde (MDA) increased, interleukin (IL)-1β IL-18 cleaved caspase-1, gasdermin D (GSDMD) involved process upregulated Kelch-like ECH-associated protein 1 (Keap1) expression upregulated, nuclear factor erythroid 2-related 2 (Nrf2) downregulated. Compared those group, Chr-treated improved dysfunction, weakened thylakoid membrane thickening, reduced tissue proliferation Additionally, SOD levels, decreased MDA, IL-1β, IL-18, down-regulated GSDMD, Keap1 expression, Nrf2 which reversed DNmice activating Keap1/Nrf2 pathway.

Language: Английский

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Curcumin ameliorates pyroptosis in diabetic seminal vesicles by upregulating TRPV6

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Abstract Background Diabetes damages the seminal vesicle tissues leading to a decrease in fluid secretion, so investigations are ongoing identify specific therapeutic approaches address diabetes‐induced damage vesicles. Objective This study investigated secretory dysfunction of vesicles and how curcumin can ameliorate this dysfunction. Materials methods First, 40 diabetic males (DM group) nondiabetic (control underwent ultrasound evaluation ejaculate volume measurements. Then, effects on function were rat model. Fifty 8‐week‐old SPF‐grade SD rats categorized into five groups: control, DM (diabetes mellitus), low‐dose CUR (curcumin 50 mg/kg/d), medium‐dose 100 high‐dose 150 mg/kg/d). After month‐long diet with varying doses, key parameters such as body weight, blood glucose levels, volume, secretion measured. Transcriptome sequencing was performed assess differences gene expression structural changes examined by HE staining. Finally, human cell lines cultured divided groups (HG‐CON, HG‐CUR‐5 µM, HG‐CUR‐10 HG‐CUR‐20 HG‐CUR‐50 µM) measure fructose levels culture fluids evaluate CASP1, GSDMD, TRPV6. Post TRPV6 interference, variations monitored. Results Diabetic patients exhibited notable reduction compared control group, direct correlation between volume. Animal studies demonstrated that supplementation significantly augmented notably improved their dysfunction, particularly group. experimental verification pinpointed differential TPRV6 pyroptosis‐associated genes (CASP1, GSDMD), reduced but increased markers pyroptosis (CASP1 GSDMD) rats. Curcumin treatment reversed these an increase GSDMD CASP1. Cell transfection experiments indicated downregulation CASP1 expression. Conclusion effectively activates TRPV6, thereby diminishing activation not only leads also ameliorates

Language: Английский

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CLEC5A Promotes Neuronal Pyroptosis in Rat Spinal Cord Injury Models by Interacting with TREM1 and Elevating NLRC4 Expression

eNeuro, Journal Year: 2024, Volume and Issue: 11(10), P. ENEURO.0111 - 24.2024

Published: Aug. 26, 2024

Pyroptosis, an inflammatory programmed cell death, has recently been found to play important role in spinal cord injury (SCI). C-type lectin domain family 5 member A (CLEC5A), triggering receptor expressed on myeloid cells 1 (TREM1), and NLR-family CARD-containing protein 4 (NLRC4) have reported be associated with neuronal pyroptosis, but few studies clarified their functions regulatory mechanisms SCI. In this study, CLEC5A, TREM1, NLRC4 were highly lidocaine-induced SCI rat models, knockdown alleviated The elevation of pyroptosis-related indicators LDH, ASC, GSDMD-N, IL-18, caspase-1, IL-1β levels rats was attenuated after silencing or NLRC4. Lidocaine-induced decrease viability the death partly reversed silencing. Lidocaine-mediated effects PC12 weakened by downregulating CLEC5A could interact TREM1 mediate expression, thus accelerating ultimately leading exacerbation. conclusions, interacted increase promoting pyroptosis providing new insights into

Language: Английский

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O-GlcNAcylation dictates pyroptosis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

O-GlcNAcylation is a dynamic post-translational modification involving the attachment of N-acetylglucosamine to serine and threonine residues. This review emphasizes its role in regulating signaling pathways pyroptosis. Specifically, GSDMD linked modulation pyroptosis, suggesting that enhancing could be crucial for improving hypoperfusion sepsis. Additionally, GSDME, another member gasdermin family, facilitates macrophage pyroptosis through induced by high glucose levels context periodontitis. The also examines effects on NLRP3 inflammasome regulators, including NEK7 NF-κB. Overall, this pathogenesis conditions such as sepsis, periodontitis, osteoarthritis, identifying potential therapeutic targets managing inflammatory responses targeted modulation.

Language: Английский

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