Unleashing the potential of cyclodextrin-based nanosponges in management of colon cancer: A review

Nanofabrication, Journal Year: 2024, Volume and Issue: 9

Published: May 27, 2024

Colon cancer ranked second in terms of incidence the world, yearly it shows an increase tendency mortality. It is estimated that by year 2035 total number deaths will 75 %. The treatment includes surgery, radiation therapy, and chemotherapy, however, they are limited due to their targeted therapeutic potential side effects. In case a conventional drug delivery system, desired system should be able protect from degradation safety target site. Cyclodextrin-based nanosponges (NS) versatile platform for colon treatment, surpassing limitations systems. Nanosponge offers several advantages such as improved solubility, enhanced stability, delivery, combination therapy its highly cross-linked structure. fabrication NS use biopolymers controlled release drugs pores through diffusion. These can efficiently encapsulate wide range agents, enabling regulated release, addressing challenges associated with poor solubility stability used management cancer. Additionally, functionalization enables cells, minimizing off-target Though benefits NS, further research needed address regulatory considerations scale up translation into clinical practice. Overall, cyclodextrin-based holds promise revolutionizing improving patient outcomes.

Language: Английский

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Nanomedicine breakthrough: Cyclodextrin-based nano sponges revolutionizing cancer treatment

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101358 - 101358

Published: Sept. 28, 2024

Language: Английский

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Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation

Brazilian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 61

Published: Jan. 1, 2025

Abstract This research aims to create dabrafenib (DBF)-loaded nanosponges (NSPs) using β-cyclodextrin (β-CD) and diphenyl carbonate (DPC) as linker improve oral bioavailability. DBF-loaded β-CD NSPs were synthesized by finely adjusting the molar ratio of DPC optimizing stirring rate duration design methodology. After being loaded with DBF, produced characterized in terms particle size, zeta potential (Z.P), polydispersity index (PdI), drug entrapment efficiency (E.E). Studies on compatibility carried out FTIR (Fourier Transform Infrared Spectroscopy) DSC (Differential Scanning Calorimetry). Permeability, vivo, vitro experiments performed improved pure medication. NSPs, a formulation mean size 158.0 ± 7.2 nm, PdI 0.282 0.0044, E.E 86.23 2.45% was obtained, based assessments indicated earlier. Zeta sizer, SEM, spectrum analysis, release, pharmacokinetic tests among other analyses that further validated optimization. An area under curve (AUC0-t) 7.95-fold greater Cmax 7.356 times higher than those free demonstrated optimized which showed notable boost. The use holds promise an effective strategy for enhancing release bioavailability treatment melanoma.

Language: Английский

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Optimizing Ibrutinib Bioavailability: Formulation and Assessment of Hydroxypropyl-β-Cyclodextrin-Based Nanosponge Delivery Systems

Current Research in Pharmacology and Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100213 - 100213

Published: Jan. 1, 2025

Language: Английский

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Nanosponges : Formulation And Evaluation Of Nanosponges

International Journal of Advanced Research in Science Communication and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 117 - 129

Published: Jan. 27, 2025

This review aims that the study of to formulate and evaluate nonosponges as a Novel drug delivery systems, exploiting their potential improve biological availability with long half lives. Nanosponges, tiny mesh structure enhanced ability encapsulate water lipid soluble drug, have gained significant attention in field pharmaceuticals. These spherical colloidal particles possess hydrophobic core, allowing for transport therapeutic molecules both hydrophilic properties composed 3D network -chain polyester backbones cross -linkers, can be synthesized through treatment cyclodextrins appropriate cross-linkers. The will investigate physicochemical properties, in-vitro release profile efficiency nonosponges, providing insights into applications pharmaceutical technology.

Language: Английский

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Host–Guest Dynamic Behavior of Melatonin Encapsulated in β-Cyclodextrin Nanosponges

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Cyclodextrin-based nanosponges are cross-linked polymeric porous nanomaterials obtained by condensation of cyclodextrins with a polyfunctional reagent (cross-linker). Owing to their high surface area, they attractive for encapsulation applications aimed at increasing the stability, solubility, and bioavailability drugs. Due structural complexity these emerging materials, computer modeling can provide atomistic-level insights into both flexibility interactions encapsulated In this contribution, we focus on β-cyclodextrin citric acid full-atom models linear cyclic topologies. We use extensive molecular dynamics (MD) simulations analyze constructs melatonin, neurohormone involved in sleep-wake cycle regulation also used as an antioxidant immunomodulator. characterize main responsible melatonin binding show that it benefits from multivalence crowding effects.

Language: Английский

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Enhanced delivery of Dacarbazine using Nanosponge loaded Hydrogel for Targeted Melanoma Treatment: Formulation, Statistical Optimization and Pre-clinical Evaluation

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 1, 2025

Language: Английский

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Therapeutic Action of Capsaicin in the Management of Pain in Osteoarthritis

Advances in Science, Technology & Innovation/Advances in science, technology & innovation, Journal Year: 2025, Volume and Issue: unknown, P. 181 - 193

Published: Jan. 1, 2025

Language: Английский

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Development and in-vitro Assessment of Topical Gel of Celecoxib-Loaded Nanosponges for the Rheumatoid Arthritis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Background Osteoarthritis is characterised by degenerative changes, while rheumatoid arthritis an inflammatory disorder swelling and inflammation in the synovial membranes of joints, which leads to bone erosion joint deformity. Although new drugs have expanded treatment options, severe can significantly impair physical functions. Methods Using Emulsion Solvent Evaporation technology with a 3²-factorial design. Various concentrations ethyl-cellulose (EC) poly-vinyl alcohol (PVA) as rate-inhibiting copolymers. The Nanosponges were also tested for particle size (PS), zeta potential (ZP), entrapment efficacy (EE), drug loading. It was subjected physicochemical characterisation using FT-IR, XRD, TEM SEM. Carbopol 934P gel treated optimised CENS containing equal amount Celecoxib. celecoxib-loaded NS further viscosity, spreadability, diffusion, stability, skin irritation. Results CENS2 constituted Celecoxib, EC, PVA, (259 ± 0.63nm), ZP (-7.01 0.01 mV), %EE (98.1%). tests produced showed polymer-drug compatibility, efficient encapsulation, that remained non-crystalline within spherical NS. CENS3 topical gels revealed 86.3% diffusion Franz cells after good release. Conclusion current study suggests CENS3-based could improve transdermal delivery process without inducing Celecoxib prove effective against Rheumatoid arthritis.

Language: Английский

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Developing novel β‐cyclodextrin‐based nanosponge as nanocarrier of hydroxyurea anticancer agent

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract The emergence of advanced nanosponge materials has opened new frontiers in nanotechnology, offering unparalleled structural versatility and surface adaptability. In this study, a novel β‐cyclodextrin (βCD)‐based system was synthesized using three distinct cross‐linkers—maleic anhydride, epichlorohydrin, their combination each—contributing to unique network architecture with tunable porosity stability. This study highlights the replacement toxic cross‐linkers, such as epichlorohydrin maleic more biocompatible alternative. By comparing systems two crosslinking agents, were identified, most effective nanomaterial determined. To further amplify area functional capacity, halloysite nanotubes (HNT) incorporated into system, resulting an innovative nanocomposite expanded, highly accessible interface. Incorporating HNT matrix significantly enhances area, evidenced by Brunauer–Emmett–Teller (BET) analysis, which demonstrates marked increase both nanosponges. A detailed examination synergy between conducted through situ ex approaches, revealing intricate interplay that governs material's integrity Structural characterization attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), proton nuclear magnetic resonance ( 1 H‐NMR), scanning electron microscopy (SEM), transmission (TEM) confirmed formation exceptionally porous, chemically robust nanoscale framework. Significantly, work underscores design next‐generation, material, free components, featuring expanded capable enhancing bioavailability cancer drugs while simultaneously reducing associated toxicity. approach opens avenues for drug delivery therapy beyond. Highlights nanosponges MA, EPI, MA‐EPI. Nanocarrier decorated (βCD@HNT) prepared facile route. Nanosponges applied binding carrying hydroxyurea (HX@βCD@HNT). Nanosponge its carrier characterized FTIR, NMR, XPS, BET. Morphology β‐cyclodextrin‐based nanocarriers enlightened SEM TEM.

Language: Английский

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